Novel opportunities for clinical pharmacy research: development of a machine learning model to identify medication related causes of delirium in different patient groups
AbstractThe advent of artificial intelligence (AI) technologies has taken the world of science by storm in 2023. The opportunities of this easy to access technology for clinical pharmacy research are yet to be fully understood. The development of a custom-made large language model (LLM) (DELSTAR) trained on a wide range of internationally recognised scientific publication databases, pharmacovigilance sites and international product characteristics to help identify and summarise medication related information on delirium, as a proof-of-concept model, identified new facilitators and barriers for robust clinical pharmacy prac...
Source: International Journal of Clinical Pharmacy - April 9, 2024 Category: Drugs & Pharmacology Source Type: research

Clinical pharmacy key performance indicators for hospital inpatient setting: a systematic review
ConclusionThe KPIs formulated for evaluating CPS in hospital settings primarily comprised process measures, predominantly suggested by pharmacists, with inadequate evidence support, lacked piloting or validation, and consequently, were devoid of benchmarking reference values. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 3, 2024 Category: Drugs & Pharmacology Source Type: research

An umbrella review of the diagnostic value of next-generation sequencing in infectious diseases
ConclusionThis umbrella analysis indicates that NGS is a promising technique for diagnosing pneumocystis pneumonia and periprosthetic/prosthetic joint infection with excellent sensitivity and specificity. More high-quality original research and SRs are needed to verify the current findings. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 3, 2024 Category: Drugs & Pharmacology Source Type: research

Clinical pharmacy key performance indicators for hospital inpatient setting: a systematic review
ConclusionThe KPIs formulated for evaluating CPS in hospital settings primarily comprised process measures, predominantly suggested by pharmacists, with inadequate evidence support, lacked piloting or validation, and consequently, were devoid of benchmarking reference values. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 3, 2024 Category: Drugs & Pharmacology Source Type: research

An umbrella review of the diagnostic value of next-generation sequencing in infectious diseases
ConclusionThis umbrella analysis indicates that NGS is a promising technique for diagnosing pneumocystis pneumonia and periprosthetic/prosthetic joint infection with excellent sensitivity and specificity. More high-quality original research and SRs are needed to verify the current findings. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 3, 2024 Category: Drugs & Pharmacology Source Type: research

Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: a pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database
ConclusionPsychiatric adverse events comprised only 1.2% of the total reports for semaglutide, liraglutide, and tirzepatide. However, the severity and fatal outcomes of some of these reports warrant further investigation. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 25, 2024 Category: Drugs & Pharmacology Source Type: research

Correction: The effectiveness and safety of bevacizumab versus cetuximab in the treatment of colorectal cancer: a systematic review and meta ‑analysis
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 25, 2024 Category: Drugs & Pharmacology Source Type: research

The efficacy of zuranolone versus placebo in postpartum depression and major depressive disorder: a systematic review and meta-analysis
ConclusionThe results suggest that zuranolone can improve symptoms of PPD at 15  days; however, results were not clinically significant for MDD. Future research is needed to evaluate the long-term efficacy of zuranolone in PPD and the treatment efficacy in MDD. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 15, 2024 Category: Drugs & Pharmacology Source Type: research

Implementation of medication reviews in community pharmacy: reaching consensus on stakeholders ’ recommendations for mechanisms of change using the nominal group technique
ConclusionThis study identified stakeholders ’ priorities for mechanisms of change to implement MRs in community pharmacies. Focusing efforts on the prioritised mechanisms is likely to significantly advance a national implementation plan for countries which are at an early implementation stage. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 15, 2024 Category: Drugs & Pharmacology Source Type: research

The efficacy of zuranolone versus placebo in postpartum depression and major depressive disorder: a systematic review and meta-analysis
ConclusionThe results suggest that zuranolone can improve symptoms of PPD at 15  days; however, results were not clinically significant for MDD. Future research is needed to evaluate the long-term efficacy of zuranolone in PPD and the treatment efficacy in MDD. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 15, 2024 Category: Drugs & Pharmacology Source Type: research

Implementation of medication reviews in community pharmacy: reaching consensus on stakeholders ’ recommendations for mechanisms of change using the nominal group technique
ConclusionThis study identified stakeholders ’ priorities for mechanisms of change to implement MRs in community pharmacies. Focusing efforts on the prioritised mechanisms is likely to significantly advance a national implementation plan for countries which are at an early implementation stage. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 15, 2024 Category: Drugs & Pharmacology Source Type: research

A qualitative study exploring the challenges and enablers of pharmacists with a recent background in community pharmacy transitioning into primary care
ConclusionPharmacists in our study reported a range of challenges (such as examination skills, improved clinical and therapeutics knowledge) required to practice in primary care, while their regular patient contact and knowledge of community pharmacy workings enabled their transition. Previous sectors of practice should be taken into consideration when inducting pharmacists into a new role and background specific inductions may need to be implemented to support these pharmacists work autonomously at an advanced level. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 13, 2024 Category: Drugs & Pharmacology Source Type: research

European Society of Clinical Pharmacy: ‘Implementing and scaling sustainable clinical pharmacy’
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 13, 2024 Category: Drugs & Pharmacology Source Type: research

A qualitative study exploring the challenges and enablers of pharmacists with a recent background in community pharmacy transitioning into primary care
ConclusionPharmacists in our study reported a range of challenges (such as examination skills, improved clinical and therapeutics knowledge) required to practice in primary care, while their regular patient contact and knowledge of community pharmacy workings enabled their transition. Previous sectors of practice should be taken into consideration when inducting pharmacists into a new role and background specific inductions may need to be implemented to support these pharmacists work autonomously at an advanced level. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 13, 2024 Category: Drugs & Pharmacology Source Type: research