International Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
ConclusionThe safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research

New therapeutic target molecules for gastric and gastroesophageal junction cancer
AbstractMolecularly targeted therapy for receptor tyrosine kinases (RTKs) has faced limitations in gastric and gastroesophageal junction (G/GEJ) cancer except for HER2-targeted agents, possibly due to inappropriate assay selection that has hindered identification of sensitive patients, in addition to coexisting genetic abnormalities as well as intratumoral heterogeneity. Immunohistochemistry of RTKs has, thus, proved largely unsuccessful for patient selection, and detection of RTK gene amplification as a true oncogenic driver is problematic given the small numbers of affected individuals.FGFR2 amplification is associated w...
Source: International Journal of Clinical Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research

Early experience and future prospects regarding use of newly developed surgical robot system, hinotori, in the field of urologic cancer surgery
AbstractIn the field of urology, robotic surgery has gained rapid and wide acceptance as a standard surgical approach in the majority of major surgeries over the last decade. To date, the da Vinci surgical system has been the dominant platform in robotic surgery; however, several newly developed robotic systems have recently been introduced in routine clinical practice. Of these, hinotori, the first made-in-Japan robotic system, is characterized by various unique and attractive features different from the existing system, and the use of this system has gradually increased mainly in urologic cancer surgeries, including radi...
Source: International Journal of Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research

PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs: approval of nivolumab for unresectable advanced or recurrent epithelial skin malignancies in Japan
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research

Current status and prospects of artificial intelligence in breast cancer pathology: convolutional neural networks to prospective Vision Transformers
AbstractBreast cancer is the most prevalent cancer among women, and its diagnosis requires the accurate identification and classification of histological features for effective patient management. Artificial intelligence, particularly through deep learning, represents the next frontier in cancer diagnosis and management. Notably, the use of convolutional neural networks and emerging Vision Transformers (ViT) has been reported to automate pathologists ’ tasks, including tumor detection and classification, in addition to improving the efficiency of pathology services. Deep learning applications have also been extended to t...
Source: International Journal of Clinical Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
ConclusionsOur data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 14, 2024 Category: Cancer & Oncology Source Type: research

English version of Japanese Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) issued by the Japan Society of Clinical Oncology
AbstractThe Japan Society of Clinical Oncology Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) have been published in accordance with the Minds Manual for Guideline Development 2014 and 2017. A specialized team independent of the working group for the revision performed a systematic review. Since GIST is a rare type of tumor, clinical evidence is not sufficient to answer several clinical and background questions. Thus, in these guidelines, we considered that consensus among the experts who manage GIST, the balance between benefits and harms, patients ’ wishes, medical economic perspective, etc...
Source: International Journal of Clinical Oncology - April 13, 2024 Category: Cancer & Oncology Source Type: research

Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma
ConclusionsFAP-positive fibroblasts may contribute to tumor stroma formation in early-stage lung adenocarcinoma, and this could influence the development of therapeutic strategies targeting FAP-positive CAFs for disrupting extracellular matrix formation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 11, 2024 Category: Cancer & Oncology Source Type: research

Preoperative predictive factors for positive peritoneal cytology results in patients with pancreatic ductal adenocarcinomas: a retrospective study
ConclusionsThe indications for curative-intent surgery should be considered carefully in patients with high-risk factors for positive peritoneal cytology results. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 10, 2024 Category: Cancer & Oncology Source Type: research

Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
ConclusionWe established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research

Exploratory analysis of serum HER2 extracellular domain for HER2 positive gastric cancer treated with SOX plus trastuzumab
ConclusionsBaseline sHER2 ECD levels and its early decline may be useful biomarkers for SOX plus trastuzumab efficacy in HER2 positive gastric cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research

Psoas mass index at the level of the third lumbar vertebra on computed tomography is a prognostic predictor for metastatic castration-sensitive prostate cancer
ConclusionsPretreatment psoas muscle index is an independent predictor of poor castration-resistant prostate cancer-free survival and overall survival in patients with N1 and/or M1 metastatic castration-sensitive prostate cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research

Development and validation of a nomogram to predict overall survival in patients with redefined anaplastic thyroid carcinoma based on the SEER database
ConclusionWe constructed a nomogram to provide a convenient and reliable tool for predicting OS in rATC patients. Prognostic factors influencing CSS were not identical in patients with ATC and PSCCTh. These findings indicate that different clinical treatment and management plans are required for patients with these two types of thyroid cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 7, 2024 Category: Cancer & Oncology Source Type: research

Impact of disease volume on survival efficacy of triplet therapy for metastatic hormone-sensitive prostate cancer: a systematic review, meta-analysis, and network meta-analysis
ConclusionsTriplet therapy improves OS in mHSPC patients compared to docetaxel-based doublet therapy, irrespective of disease volume. However, based on treatment ranking, triplet therapy should preferably be considered for patients with high-volume mHSPC while those with low-volume are likely to be adequately treated with ARSI  + ADT. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research

MMP1, IL-1 β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
ConclusionMMP1 may be associated with severe irAE, and MMP1, IL-1 β, sTNFR-1, and IL-6 could serve as prognostic factors in unresectable or metastatic RCC treated with ICIs. MMP1 and IL-6 were independent predictors of PFS and OS, respectively. Thus, inhibiting these soluble factors may be promising for enhancing antitumor responses in patients with RCC treated w ith ICIs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research