Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF- β1/Smad2 signaling pathway
In conclusion, WSLE NE markedly enhanced the permeability of plant extract constituents through the blood brain barrier to boost its neuroprotective effect against PEN-induced neurotoxicity. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluating the docetaxel effect in an animal model of polyarthritis
ConclusionDTX reduces the progression and joint destruction in rats induced by Complete Freund ’s Adjuvant which may due to inhibition of PAD4, TNF-α, IL-1β, VEGF, and ACPA. Also, methotrexate exhibited anti PAD4 effect. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 15, 2024 Category: Drugs & Pharmacology Source Type: research
Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
ConclusionThis large-scale real-world data study suggest thatenalapril andcandesartan are associated with a considerable reduction in risk of severe COVID19 outcomes. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 15, 2024 Category: Drugs & Pharmacology Source Type: research
Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease
This study comprehensively analyses MSC derived from multiple sources, including bone marrow, adipose tissue, umbilical cord, and other potential reservoirs. Core elements of this investigation include assessing differences in cell acquisition, immunomodulatory effects, and differentiation capabilities among these MSC sources, as well as comparing their clinical trial outcomes in IBD patients to their therapeutic efficacy in animal models. Through meticulous evaluation and comparative analysis, this thesis aims to elucidate disparities in the efficacy of different MSC sources for IBD treatment, thereby identifying the most...
Source: Inflammopharmacology - April 14, 2024 Category: Drugs & Pharmacology Source Type: research
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
This study investigated the hydroethanolic extract ofArtemisia herba-alba for its protective potential against arthritis hallmarks, oxidative stress, and lipid peroxidation in vitro. It also assessed its in vivo anti-arthritic activity. The phytochemical analysis identified various compounds within the extract, with high concentrations of polyphenols and flavonoids. These compounds are associated with numerous health benefits, makingA. herba-alba a potential source of valuable phytochemicals.A. herba-alba demonstrated a notable effect in body weight loss, paw edema, and arthritic severity. Histopathological examination rev...
Source: Inflammopharmacology - April 12, 2024 Category: Drugs & Pharmacology Source Type: research
Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF- κB levels
This study investigated the immune-modulatory and anti-inflammatory properties ofT. ferdinandiana fruit and leaf extracts by evaluating their inhibition of multiple pro- and anti-inflammatory cytokines and chemokines secretion in lipopolysaccharide (LPS)-stimulated and unstimulated RAW 264.7 macrophages using multiplex bead immunoassays and ELISA assays. The methanolic extracts were particularly good immune-modulators, significantly inhibiting the secretion of all the cytokines and chemokines tested. Indeed, the methanolic extracts completely inhibited IL-10, IFN- γ, IL-1β, IL-6, MCP-1, and MIP-2a secretion, and almost c...
Source: Inflammopharmacology - April 6, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis
ConclusionThis meta-analysis revealed that the CS (with decreased pain intensity and improvement in the physical function), and GS (with significant reduction in the joint space narrowing) have significant therapeutic benefits. However, their combination did not significantly improve the symptoms or modify the disease. This may be due to the limited trials that are available on the combination of the sulfate forms of the intervention. Hence, there is a scope for conducting multicentric randomised controlled trials to evaluate and conclude the therapeutic role of CS and GS combination in the management of KOA. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 6, 2024 Category: Drugs & Pharmacology Source Type: research
Atopic dermatitis: treatment and innovations in immunotherapy
AbstractAtopic dermatitis (AD) is a common inflammatory skin disease characterized by itching and skin barrier dysfunction. Moderate to severe AD is often refractory to first-line topical treatments, and systemic immunosuppressants have been shown to be effective but have significant adverse effects. The paucity of basic treatments has contributed to the development of targeted topical and systemic immunotherapies based on the use of small molecules and biologic drugs which can directly interact with AD pathogenetic pathways. They represent a new era of therapeutic innovation. Additional new treatments are desirable since ...
Source: Inflammopharmacology - April 6, 2024 Category: Drugs & Pharmacology Source Type: research
Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway
ConclusionThe results clearly indicate that sinomenine demonstrated a protective effect against DSS-induced inflammation, potentially through the modulation of inflammatory pathways and gut microbiota. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches
AbstractGastric ulcers affect approx. 10% of population. Non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid (ASA) predispose to or impair the physiologically complex healing of pre-existing ulcers. Since H2S is an endogenous cytoprotective molecule, we hypothesized that new H2S-releasing ASA-derivative (ATB-340) could overcome pathological impact of NSAIDs on GI regeneration.Clinically translational gastric ulcers were induced in Wistar rats using state-of-the-art microsurgical model employing serosal application of acetic acid. This was followed by 9 days long i.g. daily treatment with vehicl...
Source: Inflammopharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review
AbstractInflammation can be triggered by any factor. The primary pathological manifestations can be summarized as the deterioration, exudation, and proliferation of local tissues, which can cause systemic damage in severe cases. Inflammatory lesions are primarily localized but may interact with body systems to cause provocative storms, parenchymal organ lesions, vascular and central nervous system necrosis, and other pathologic responses. Tetrandrine (TET) is a bisbenzylquinoline alkaloid extracted from the traditional Chinese herbal medicineStephania tetrandra, which has been shown to have significant efficacy in inflamma...
Source: Inflammopharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Autophagy and exosomes; inter-connected maestros in Alzheimer ’s disease
In conclusion, our findings suggest that autophagy alterations in AD can influence the release of Aβ and tau proteins through exosomes, which may impact the spread of misfolded proteins in AD. These results highlight a potential innovative therapeutic approach for combating AD. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 2, 2024 Category: Drugs & Pharmacology Source Type: research
In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis- à-vis normal garlic
AbstractSnow mountain garlic (SMG) is atrans-Himalayan medicinal plant used in the traditional medicine system for several ailments, including inflammatory arthritis. Research studies are insufficient to validate its folk medicinal applications. In the present study, the comparative abundance of its key bioactive phytocompounds, viz., S-allyl-L-cysteine (SAC), alliin, and S-methyl-L-cysteine (SMC) against normal garlic were assessed using the LC –MS/MS-MRM method. In addition, the study also explored the antioxidant and anti-inflammatory potency of crude extract of SMG and purified signature phytocompounds (i.e., SMC, SA...
Source: Inflammopharmacology - April 2, 2024 Category: Drugs & Pharmacology Source Type: research
Correction to: Melatonin ameliorates osteoarthritis rat cartilage injury by inhibiting matrix metalloproteinases and JAK2/STAT3 signaling pathway
(Source: Inflammopharmacology)
Source: Inflammopharmacology - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice
This study aimed to investigate anti-gout and anti-inflammatory properties of curcumin nanoparticles (CNPs). For this purpose, CNPs were prepared by dissolving curcumin into dichloromethane. Then, gout was induced by injecting monosodium urate crystals (MSU) in the ankle joint and in the intra-per itoneal cavity which caused ankle swelling and increased blood uric acid levels. CNPs in different concentrations (5, 10, and 20 ppm) and allopurinol were orally administered. The MSU crystals increased the xanthine oxidase levels both in serum and the liver. Moreover, MSU crystals increased the se rum levels of interleukin 1β,...
Source: Inflammopharmacology - March 31, 2024 Category: Drugs & Pharmacology Source Type: research
