Long Non-Coding RNA-GDA-1 Promotes Keratinocyte Proliferation and Psoriasis Inflammation by Regulating the STAT3/NF- κB Signaling Pathway via Forkhead Box M1
In conclusion, our study is the first to report that Lnc-GDA-1 distinctly regulates FOXM1 expression and mediates proliferation and inflammation of psoriatic keratino cytes through the STAT3/NF-κB signaling pathway, which may be a potent target for psoriasis treatment. (Source: Inflammation)
Source: Inflammation - July 22, 2023 Category: Allergy & Immunology Source Type: research
Effect of the Non-steroidal Anti-inflammatory Drug Diclofenac on Ischemia –Reperfusion Injury in Rat Liver: A Nitric Oxide-Dependent Mechanism
AbstractIschemia/reperfusion injury (IRI) is an inevitable complication of liver surgery and transplantation. The purpose of this study was to examine the beneficial effects of diclofenac on hepatic IRI and the mechanism behind it. Wistar rats ’ livers were subjected to warm ischemia for 60 min followed by 24 h of reperfusion. Diclofenac was administered intravenously 15 min before ischemia at 10, 20, and 40 mg/kg body weight. To determine the mechanism of diclofenac protection, the NOS inhibitor L-Nitro-arginine methyl ester (L-NAM E) was administered intravenously 10 min after diclofenac injection (40 mg/kg). Liv...
Source: Inflammation - July 22, 2023 Category: Allergy & Immunology Source Type: research
Dehydration Accelerates Cytogenesis and Cyst Growth in Pkd1 −/− Mice by Regulating Macrophage M2 Polarization
AbstractAdult autosomal dominant polycystic kidney disease (ADPKD) has been shown to be related as a “third hit” to the occurrence of acute or chronic kidney injury. Here, we examined whether dehydration, as a common kidney risk factor, could cause cystogenesis in chronic-onsetPkd1−/− mice by regulating macrophage activation. First, we confirmed that dehydration accelerated cytogenesis inPkd1−/− mice and that macrophages infiltrated the kidney tissues even earlier than macroscopic cyst formation. Then, microarray analysis suggested that glycolysis pathway may be involved in macrophage activation inPkd1−/− k...
Source: Inflammation - July 20, 2023 Category: Allergy & Immunology Source Type: research
Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans
In conclusion, 2-HOBA significantly altered the protein biomarkers CCL19, IL-12β, IL-20Rα, TNFβ, and TWEAK, and these may be responsible for the protective effects of 2-HOBA against reactive electrophiles, such as IsoLGs, commonly expressed in conditions of excessive oxidative stress. 2-HOBA has a role as a IsoLG scavenger to proactively improve immune health in a variety of conditions. (Source: Inflammation)
Source: Inflammation - July 20, 2023 Category: Allergy & Immunology Source Type: research
Cross-Talk between Mucosal-Associated Invariant T, Natural Killer, and Natural Killer T Cell Populations is Implicated in the Pathogenesis of Placenta Accreta Spectrum
AbstractThe study included 32 women with PAS and 20 with normally implanted placenta as a control group. Vascular endothelial cell growth factor (VEGF), Soluble FMS Like Tyrosine Kinase (sFLT-1/sVEGFR1), and Endoglin (ENG) were measured in placenta tissue by ELISA. Granzyme B (GrzB) expression in trophoblastic and stromal mesenchymal cells was evaluated by immunohistochemistry. MAIT, NK, and NKT cells were assessed in blood and placenta by flow cytometry. Alterations were observed in levels of MAIT cells, NK cell subsets, and NKT cells in patients compared with controls. Several significant correlations were detected betwe...
Source: Inflammation - July 20, 2023 Category: Allergy & Immunology Source Type: research
