Interleukin-4 Modulates Neuroinflammation by Inducing Phenotypic Transformation of Microglia Following Subarachnoid Hemorrhage
AbstractNeuroinflammation, a key pathological feature following subarachnoid hemorrhage (SAH), can be therapeutically targeted by inhibiting microglia M1 polarization and promoting phenotypic transformation to M2 microglia. Interleukin-4 (IL-4) is a pleiotropic cytokine known to its regulation of physiological functions of the central nervous system (CNS) and mediate neuroinflammatory processes. However, its specific role in neuroinflammation and microglia responses following SAH remains unexplored. In this investigation, we established bothin vivo andin vitro SAH models and employed a comprehensive array of assessments, i...
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
lncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5
AbstractDespite the substantial progress in deciphering the pathogenesis of atherosclerosis (AS), cardiovascular mortality is still increasing. Therefore, atherosclerotic cardiovascular disease remains a sweeping epidemic that jeopardizes human health. Disentangling the molecular underpinnings of AS is imperative in the molecular cardiology field. Overwhelming evidence has indicated that the recognition of a fascinating class of players, known as long non-coding RNAs (lncRNAs), provides causality for coordinating AS. However, the function and mechanism of HOTAIRM1 are still poorly understood in human umbilical vein endothe...
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia ‒Reperfusion Injury
In conclusion, we believe that MS suppresses MAMs and activation of the NLRP3 inflammasome by regulating the PERK signaling pathway to ameliorate intestinal I/R injury. (Source: Inflammation)
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
Interleukin-4 Modulates Neuroinflammation by Inducing Phenotypic Transformation of Microglia Following Subarachnoid Hemorrhage
AbstractNeuroinflammation, a key pathological feature following subarachnoid hemorrhage (SAH), can be therapeutically targeted by inhibiting microglia M1 polarization and promoting phenotypic transformation to M2 microglia. Interleukin-4 (IL-4) is a pleiotropic cytokine known to its regulation of physiological functions of the central nervous system (CNS) and mediate neuroinflammatory processes. However, its specific role in neuroinflammation and microglia responses following SAH remains unexplored. In this investigation, we established bothin vivo andin vitro SAH models and employed a comprehensive array of assessments, i...
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
lncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5
AbstractDespite the substantial progress in deciphering the pathogenesis of atherosclerosis (AS), cardiovascular mortality is still increasing. Therefore, atherosclerotic cardiovascular disease remains a sweeping epidemic that jeopardizes human health. Disentangling the molecular underpinnings of AS is imperative in the molecular cardiology field. Overwhelming evidence has indicated that the recognition of a fascinating class of players, known as long non-coding RNAs (lncRNAs), provides causality for coordinating AS. However, the function and mechanism of HOTAIRM1 are still poorly understood in human umbilical vein endothe...
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia ‒Reperfusion Injury
In conclusion, we believe that MS suppresses MAMs and activation of the NLRP3 inflammasome by regulating the PERK signaling pathway to ameliorate intestinal I/R injury. (Source: Inflammation)
Source: Inflammation - October 29, 2023 Category: Allergy & Immunology Source Type: research
EGR1 Mediated Reduction of Fibroblast Secreted-TGF- β1 Exacerbated CD8+ T Cell Inflammation and Migration in Vitiligo
AbstractVitiligo is a T cell-mediated depigment skin disease caused by the complex interplay between melanocyte dysfunction, environmental stimulation, and dysregulated immune signals. Transforming growth factor- β1 (TGF-β1), which typically derives from regulatory T cells, has long been identified at low levels in the peripheral system of vitiligo patients. Here, through RNA-sequencing and transcription factor enrichment, we revealed that in response to CD8+ T cell-secreted interferon-gamma (IFN- γ), stromal fibroblast downregulates early growth response 1 (EGR1) activity, leading to TGF-β1 deficiency. The defective i...
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid –Induced Colitis in Rats
This study shows that apocynin protects rats from acetic acid–induced colonic inflammation and suggests that apocynin may have a promising beneficial effect in the prevention of ul cerative colitis. (Source: Inflammation)
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
EGR1 Mediated Reduction of Fibroblast Secreted-TGF- β1 Exacerbated CD8+ T Cell Inflammation and Migration in Vitiligo
AbstractVitiligo is a T cell-mediated depigment skin disease caused by the complex interplay between melanocyte dysfunction, environmental stimulation, and dysregulated immune signals. Transforming growth factor- β1 (TGF-β1), which typically derives from regulatory T cells, has long been identified at low levels in the peripheral system of vitiligo patients. Here, through RNA-sequencing and transcription factor enrichment, we revealed that in response to CD8+ T cell-secreted interferon-gamma (IFN- γ), stromal fibroblast downregulates early growth response 1 (EGR1) activity, leading to TGF-β1 deficiency. The defective i...
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid –Induced Colitis in Rats
This study shows that apocynin protects rats from acetic acid–induced colonic inflammation and suggests that apocynin may have a promising beneficial effect in the prevention of ul cerative colitis. (Source: Inflammation)
Source: Inflammation - October 26, 2023 Category: Allergy & Immunology Source Type: research
Fibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway
In this study, it was found that the expression of FGF21 was markedly increased in lung tissue under lipopolysaccharide (LPS) stimulationin vivo, whereas it was decreased in lung epithelial cells under LPS stimulationin vitro. Therefore, our research aimed to elucidate the potential role of FGF21 in LPS-induced ALI and to detect possible underlying mechanisms. The results revealed that the deficiency of FGF21 aggravated pathological damage, inflammatory infiltration, and pulmonary function in LPS-induced ALI, while exogenous administration of FGF21 improved these manifestations. Moreover, through RNA sequencing and enrichm...
Source: Inflammation - October 21, 2023 Category: Allergy & Immunology Source Type: research
The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time
AbstractDoxorubicin (DOX) is a topoisomerase II inhibitor used in cancer therapy. Despite its efficacy, DOX causes serious adverse effects, such as short- and long-term cardiotoxicity. This work aimed to assess the short- and long-term cardiotoxicity of DOX and the role of inflammation and antioxidant defenses on that cardiotoxicity in a mice model. Adult CD-1 male mice received a cumulative dose of 9.0 mg/kg of DOX (2 biweekly intraperitoneal injections (ip), for 3 weeks). One week (1W) or 5 months (5M) after the last DOX administration, the heart was collected. One week after DOX, a significant increase in p62, tumo...
Source: Inflammation - October 14, 2023 Category: Allergy & Immunology Source Type: research
