Prognostic Significance of NLR and PLR in COVID-19: A Multi-Cohort Validation Study
ConclusionsConsistent findings across diverse patient populations validate the reliability and applicability of NLR and PLR cut-off values. High NPVs emphasize their role in identifying individuals less likely to experience severe outcomes. These markers not only aid in risk stratification but also guide resource allocation in emergencies or limited-resource situations. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 21, 2024 Category: Infectious Diseases Source Type: research
Underlying Neural Mechanisms of Cognitive Improvement in Fronto-striatal Response Inhibition in People Living with HIV Switching Off Efavirenz: A Randomized Controlled BOLD fMRI Trial
ConclusionPotential neural mechanisms underlying cognitive improvement after discontinuing EFV in PLWH were found in subcortical functioning, with our findings suggesting that EFV ’s effect on attention and processing speed is, at least partially, mediated by reactive inhibition.Trial RegistrationClinicaltrials.gov identifier [NCT02308332]. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 20, 2024 Category: Infectious Diseases Source Type: research
Fungal Prosthetic Joint Infection: A Case Series and Review of the Literature
ConclusionsTwo-stage revision with extended antifungal therapy is preferred in these infections due to higher rates of positive outcomes. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 13, 2024 Category: Infectious Diseases Source Type: research
Ritonavir: 25 Years ’ Experience of Concomitant Medication Management. A Narrative Review
AbstractRitonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme and is commonly used as a pharmacokinetic (PK) enhancer in antiviral therapies because it increases bioavailability of concomitantly administered antivirals. Decades of experience with ritonavir-enhanced HIV therapies and, more recently, COVID-19 therapies demonstrate that boosting doses of ritonavir are well tolerated, with an established safety profile. The mechanisms of PK enhancement by ritonavir result in the potential for drug –drug interactions (DDIs) with several classes of drugs, thus making co-medication management an important considerat...
Source: Infectious Diseases and Therapy - April 12, 2024 Category: Infectious Diseases Source Type: research
Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study
ConclusionsWe showed that regdanvimab reduced the exacerbation rates of conditions and mortality in patients with the COVID-19 delta variant infection. Thus, it is recommended to streamline the drug approval system during epidemics of new variant viruses to improve the availability and usage of therapeutics for patients. To facilitate this, relevant institutional support is required. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 12, 2024 Category: Infectious Diseases Source Type: research
Ritonavir: 25 Years ’ Experience of Concomitant Medication Management. A Narrative Review
AbstractRitonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme and is commonly used as a pharmacokinetic (PK) enhancer in antiviral therapies because it increases bioavailability of concomitantly administered antivirals. Decades of experience with ritonavir-enhanced HIV therapies and, more recently, COVID-19 therapies demonstrate that boosting doses of ritonavir are well tolerated, with an established safety profile. The mechanisms of PK enhancement by ritonavir result in the potential for drug –drug interactions (DDIs) with several classes of drugs, thus making co-medication management an important considerat...
Source: Infectious Diseases and Therapy - April 12, 2024 Category: Infectious Diseases Source Type: research
Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study
ConclusionsWe showed that regdanvimab reduced the exacerbation rates of conditions and mortality in patients with the COVID-19 delta variant infection. Thus, it is recommended to streamline the drug approval system during epidemics of new variant viruses to improve the availability and usage of therapeutics for patients. To facilitate this, relevant institutional support is required. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 12, 2024 Category: Infectious Diseases Source Type: research
Systematic Review of Heel Puncture-Related Osteomyelitis of the Calcaneus in Newborn Infants
ConclusionsThis study offers valuable insights into a rare condition, including its epidemiology, clinical and laboratory characteristics, and treatment options for infants with HP-CO. To prevent the risk of osteomyelitis in this vulnerable group of patients, increasing awareness and maintaining strict aseptic techniques is necessary. We recommend that infants presenting with tenderness, redness, purulent discharge, erythema, or fever and with a history of repeated HP and swollen ankles should be evaluated for suspicion of osteomyelitis.A graphical abstract is avilable for this article.Graphical Abstract (Source: Infectiou...
Source: Infectious Diseases and Therapy - April 8, 2024 Category: Infectious Diseases Source Type: research
Structured Literature Review to Identify Human Papillomavirus ’s Natural History Parameters for Dynamic Population Models of Vaccine Impacts
This study aimed to identify and synthesize data needed to parametrize DTMs on the natural history of HPV infection and related diseases. Parameters describing data of interest were grouped by their anatomical location (genital warts, recurrent respiratory papillomatosis, and cervical, anal, vaginal, vulvar, head and neck, and penile cancers), and natural history (progression, regression, death, cure, recurrence, detection), and were identified through a systematic literature review (SLR) and complementary targeted literature reviews (TLRs). The extracted data were then synthesized by pooling parameter values across public...
Source: Infectious Diseases and Therapy - April 8, 2024 Category: Infectious Diseases Source Type: research
Systematic Review of Heel Puncture-Related Osteomyelitis of the Calcaneus in Newborn Infants
ConclusionsThis study offers valuable insights into a rare condition, including its epidemiology, clinical and laboratory characteristics, and treatment options for infants with HP-CO. To prevent the risk of osteomyelitis in this vulnerable group of patients, increasing awareness and maintaining strict aseptic techniques is necessary. We recommend that infants presenting with tenderness, redness, purulent discharge, erythema, or fever and with a history of repeated HP and swollen ankles should be evaluated for suspicion of osteomyelitis.A graphical abstract is avilable for this article.Graphical Abstract (Source: Infectiou...
Source: Infectious Diseases and Therapy - April 8, 2024 Category: Infectious Diseases Source Type: research
Structured Literature Review to Identify Human Papillomavirus ’s Natural History Parameters for Dynamic Population Models of Vaccine Impacts
This study aimed to identify and synthesize data needed to parametrize DTMs on the natural history of HPV infection and related diseases. Parameters describing data of interest were grouped by their anatomical location (genital warts, recurrent respiratory papillomatosis, and cervical, anal, vaginal, vulvar, head and neck, and penile cancers), and natural history (progression, regression, death, cure, recurrence, detection), and were identified through a systematic literature review (SLR) and complementary targeted literature reviews (TLRs). The extracted data were then synthesized by pooling parameter values across public...
Source: Infectious Diseases and Therapy - April 8, 2024 Category: Infectious Diseases Source Type: research
Seroprevalence and Shifting Endemicities of Hepatitis A Virus Infection in Two Different Geographical Areas in the Philippines
ConclusionResults suggest that HAV endemicity is low in the Philippines. Factors associated with HAV seropositivity were traveling, consuming street food and lack of basic hygienic gestures. Immunization might be an option to protect vulnerable populations against severe hepatitis A disease. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 5, 2024 Category: Infectious Diseases Source Type: research
