Primary peritoneal Epithelioid mesothelioma of clear cell type with a novel VHL gene mutation: a case report
Clear cell variant of epithelioid mesothelioma is an extremely rare tumor with only isolated cases reported so far in the peritoneum. Here, we report a case of peritoneal epithelioid mesothelioma, clear cell variant, in a 63-year-old female patient with a novel VHL gene mutation and an unusual indolent clinical course. The patient, who has no clinical history of asbestos exposure, presented with a 27.2 cm upper abdominal mass and a 5.5 cm liver lesion. Retrospective review of the patient's abdominal CT scan 4 years ago showed two small abdominal lesions that were felt clinically to represent hemangiomas. (Source: Human Pathology)
Source: Human Pathology - August 14, 2018 Category: Pathology Authors: Alexandria Smith-Hannah, Rana Naous Tags: Case study Source Type: research
Pseudo –“solid pseudopapillary neoplasms” of the testis: in reality Sertoli cell tumors
We read with interest and concern two reports published in Human Pathology [1,2] concerning testicular neoplasms that were felt to be “testicular analogues” of the well-known “solid pseudopapillary neoplasm” (SPN) of the pancreas, albeit in one of the 2 papers the authors preferred to designate the tumors as primary signet ring stromal tumors of the testis [1]. Although we acknowledge that the pseudopapillae in the SPNs ma y be limited in amount, their apparent absence, according to the descriptions of the microscopic findings in all of the 14 tumors in these 2 reports, struck us as unusual for a tumor the authors ...
Source: Human Pathology - August 12, 2018 Category: Pathology Authors: Thomas M. Ulbright, Robert H. Young Tags: Correspondence Source Type: research
Tumor necrosis factor α-induced protein 8 expression as a predictor of prognosis and resistance in patients with advanced ovarian cancer treated with neoadjuvant chemotherapy
We explored the correlation of tumor necrosis factor α-induced protein 8 (TNFAIP8) with platinum resistance in ovarian cancers (OCs) treated with neoadjuvant chemotherapy (NACT). We observed a significant trend of decreased TNFAIP8 expression after NACT (P=.042), and the extent of decreased TNFAIP8 expression following NACT was positively associated with response to NACT (P=.013). Interestingly, in patients treated with NACT, the extent of decreased TNFAIP8 expression following NACT in tumor (change in immunohistochemistry [ΔIHC] score≤−1 vs. (Source: Human Pathology)
Source: Human Pathology - August 11, 2018 Category: Pathology Authors: Jing Wang, Hongyu Gao, Guohui Liu, Lina Gu, Chang Yang, Fengmin Zhang, Tianbo Liu Tags: Original contribution Source Type: research
EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer
Epidermal growth factor receptor (EGFR) gene copy number (GCN) increase is associated with a favourable anti-EGFR antibody treatment response in RAS wild-type metastatic colorectal cancer. However, there are limited comparative data regarding the EGFR GCN in primary colorectal cancer tumours and corresponding metastases or the effect of anti-EGFR antibody treatment on EGFR GCN in recurrent disease. Additionally, little is known about the potential EGFR GCN changes during anti-EGFR therapy in comparison to other treatment regimens. (Source: Human Pathology)
Source: Human Pathology - August 7, 2018 Category: Pathology Authors: Eva-Maria Birkman, Tuulia Avoranta, Annika Ålgars, Eija Korkeila, Minnamaija Lintunen, Laura Lahtinen, Teijo Kuopio, Raija Ristamäki, Olli Carpén, Jari Sundström Tags: Original contribution Source Type: research
So-called “non-classic” ciliated Muconodular papillary tumors: a comprehensive comparison of the Clinicopathological and molecular features with classic ciliated Muconodular papillary tumors
Ciliated muconodular papillary tumors (CMPTs) are characterized by tripartite cellular components of ciliated columnar cells, mucinous cells, and basal cells with predominantly papillary architecture. Some peripheral lung nodules may not demonstrate papillary architecture and tripartite cells that show bronchiolar differentiation; these nodules are termed “CMPTs with non-classic morphology” by some authors. To validate the rationality of “non-classic” CMPTs and to analyze the clinicopathological features of CMPTs, we enrolled 21 cases of lung nodules, comprising classic CMPTs (n=11) and so-called “non-classic” ...
Source: Human Pathology - August 6, 2018 Category: Pathology Authors: Qiang Zheng, Rongkui Luo, Yan Jin, Xuxia Shen, Ling Shan, Lei Shen, Yingyong Hou, Yuan Li Tags: Original contribution Source Type: research
Chronic lymphocytic leukemia with proliferation centers in bone marrow is associated with younger age at initial presentation, complex karyotype and TP53 disruption
The presence of expanded proliferation centers (PCs) in lymph nodes involved by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has been associated with adverse clinical outcomes, but the frequency and significance of PCs in bone marrow (BM) remains unclear. The study group included 36 patients with BM involvement by CLL in which PCs were present. We compared this group with 110 randomly selected BM samples involved by CLL without morphologically discernable PCs. Patients with PCs in BM were younger (median age, 53years [range,18 –71] versus 58years [range, 31–82]; P=.007), more frequently experienced...
Source: Human Pathology - August 6, 2018 Category: Pathology Authors: Sofia Garces, Joseph D. Khoury, Rashmi Kanagal-Shamanna, Alireza Salem, Sa A. Wang, Chi Young Ok, Shimin Hu, Keyur P. Patel, Mark J. Routbort, Rajyalakshmi Luthra, Guilin Tang, Ellen J. Schlette, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Sanam Loghavi Tags: Original contribution Source Type: research
The correlation of NLRC3 expression to the progression and prognosis of hepatocellular carcinoma
NLRC3 is a member of the NLR (nucleotide-binding domain and leucine-rich repeat) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, whether NLRC3 expression correlated to the development and prognosis of hepatocellular carcinoma (HCC) is unclear. In the present study, we first used Oncomine and OncoLnc database to determine the clinical significance of NLRC3 in HCC. Then we performed quantitative real-time polymerase chain reaction (qRT-PCR), western-blot and immunohistochemical staining (IHC), and analyzed the correlation between NLRC3 ...
Source: Human Pathology - August 3, 2018 Category: Pathology Authors: Ying-Yu Ma, Guo-Hai Zhang, Jingjing Li, Shi-Bing Wang, Zhi-Ming Hu, Cheng-Wu Zhang, Erguang Li Tags: Original contribution Source Type: research
ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumours
Pancreatic neuroendocrine tumours (PanNETs) are rare neoplasms accounting for 1-2% of all pancreatic tumours. The biological behaviour of PanNETs is heterogeneous and unpredictable, adding to the difficulties of clinical management. The DAXX (death domain associated protein) and ATRX (alpha-thalassemia/mental retardation syndrome X-linked) genes encode proteins involved in SWI/SNF-like chromatin remodelling. Somatic inactivating mutations in DAXX and ATRX are frequent in PanNETs, mutually exclusive, and associated with telomere dysfunction resulting in genomic instability and alternate lengthening of telomeres. (Source: Human Pathology)
Source: Human Pathology - August 3, 2018 Category: Pathology Authors: Angela Chou, Malinda Itchins, Philip R de Reuver, Jennifer Arena BSc, Adele Clarkson BSc, Amy Sheen BSc, Loretta Sioson BSc, Veronica Cheung MChD, Aurel Perren, Christopher Nahm, Anubhav Mittal, Jaswinder S Samra, Marina Pajic, Anthony J Gill Tags: Original contribution Source Type: research
Masthead
(Source: Human Pathology)
Source: Human Pathology - August 1, 2018 Category: Pathology Source Type: research
Table of Contents
(Source: Human Pathology)
Source: Human Pathology - August 1, 2018 Category: Pathology Source Type: research
Editorial board
(Source: Human Pathology)
Source: Human Pathology - August 1, 2018 Category: Pathology Source Type: research
In This Issue
(Source: Human Pathology)
Source: Human Pathology - August 1, 2018 Category: Pathology Source Type: research
Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types
Programmed death-ligand 1 (PD-L1) expression by tumor cells is a mechanism for downregulation of antitumor T cell responses and is a target for immunotherapy in various cancers. PD-L1 status as a predictor of treatment response has led to the development of multiple platforms with different reference cutoffs. We studied 128 cases of genitourinary and head/neck carcinomas, aiming to assess the frequency of PD-L1 positivity, interobserver reliability of PD-L1 interpretation and the concordance of PD-L1 scoring between small samples from tissue microarray (TMA) and whole sections (WS) using SP263 and SP142 clones. (Source: Human Pathology)
Source: Human Pathology - August 1, 2018 Category: Pathology Authors: Chiyun Wang, Elan Hahn, Elzbieta Slodkowska, Antoine Eskander, Danny Enepekides, Kevin Higgins, Danny Vesprini, Stanley K. Liu, Michelle R. Downes, Bin Xu Tags: Original Contributions Source Type: research
Concordance levels of PD-L1 expression by immunohistochemistry, mRNA in situ hybridization, and outcome in lung carcinomas
Targeted inhibition of programmed cell death-1 (PD-1) and its ligand (PD-L1) has emerged as first-line therapy for advanced non-small cell lung cancer. While patients with high PD-L1 expression have improved outcomes with anti-PD-1/PD-L1 directed therapies, use as a predictive biomarker is complicated by robust responses in some patients with low-level expression. Furthermore, reported PD-L1 levels in lung cancers vary widely and discrepancies exist with different antibodies. PD-L1 expression was thus compared by immunohistochemistry (IHC) versus RNA in situ hybridization (ISH) in 112 lung cancers by tissue microarray: 51 ...
Source: Human Pathology - August 1, 2018 Category: Pathology Authors: Joseph D. Coppock, Ashley K. Volaric, Anne M. Mills, Alejandro A. Gru Tags: Original Contributions Source Type: research
Anaplastic thyroid carcinoma: an epidemiologic, histologic, immunohistochemical and molecular single institution study
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of thyroid cancer. A single institution thyroid cancer cohort of ATC was identified within the last ten years at our institution. Retrospective analysis revealed that the frequency of ATC was 0.5% (11/2106 thyroid carcinomas). The average age at diagnosis of ATC was 74 years, and the female to male ratio was 1.2:1. ATC presented as a rapidly enlarging neck mass involving predominantly the left thyroid lobe (7/11, 64%). Cervical adenopathy was present in 7/11 (64%) of cases. (Source: Human Pathology)
Source: Human Pathology - August 1, 2018 Category: Pathology Authors: Audrey Deeken-Draisey, Guang-Yu Yang, Juehua Gao, Borislav A. Alexie Tags: Original Contributions Source Type: research
