Preoperative Serum Thyroglobulin Levels Predict Radioiodine Therapy
Outcome in Papillary Thyroid Microcarcinoma Patients
Horm Metab Res DOI: 10.1055/a-2291-0340Our previous study showed that elevated preoperative thyroglobulin (pre-Tg) level
predicted the risk of developing radioiodine refractory in PTC patients. In the
present study, we aimed to evaluate the prognostic value of pre-Tg in papillary
thyroid microcarcinoma (PTMC). After a specific inclusion and exclusion criteria
were applied, a total of 788 PTMCs were enrolled from Jiangyuan Hospital
affiliated to Jiangsu Institute of Nuclear Medicine between Jan 2015 and Dec
2019. Among them, 107 PTMCs were treated with radioiodine ...
Source: Hormone and Metabolic Research - April 15, 2024 Category: Endocrinology Authors: Cheng, Xian Fan, Yijun Ye, Wanzhong Xu, Shichen Wu, Jing Gao, Wenjing Bao, Jiandong Yu, Huixin Zhang, Li Tags: Original Article: Endocrine Care Source Type: research
Thyroglobulin Antibodies and Tumor Epitope-Specific Cellular Immunity
in Papillary Thyroid Cancer
Horm Metab Res DOI: 10.1055/a-2278-6549Papillary thyroid carcinoma (PTC) is characterized by T cell infiltration and
frequently by the presence of anti-thyroglobulin antibodies (TgAbs). The role of
cellular immunity and of TbAbs in this context is a matter of debate. The aim of
our study was to correlate the presence of TgAbs, tumor epitope-specific T cells
and the clinical outcome of PTC patients. We studied n=183 consecutive patients
with a diagnosis of PTC which were treated with total thyroidectomy plus
131I ablation. During a follow-up of in mean 97 months,...
Source: Hormone and Metabolic Research - April 15, 2024 Category: Endocrinology Authors: Allelein, Stephanie Ehlers, Margret Thoma, Taina Mattes-Gy örgy, Katalin Antke, Christina Mamlins, Eduards Muchalla, Mareike Giesel, Frederik Schott, Matthias Tags: Original Article: Endocrine Care Source Type: research
International Roadshow: New Advances in Endocrinology and Metabolic
Diseases
Horm Metab Res 2024; 56: 259-260 DOI: 10.1055/a-2256-7180Dear Readers,Currently, there is a myriad of new developments in the field of endocrinology. In
particular, significant strides have been made in the development of poly-agonists
for the treatment of type 2 diabetes and obesity 1
2. Poly-agonists represent a
novel therapeutic approach by combining multiple actions within a single molecule,
targeting multiple receptors simultaneously to achieve enhanced efficacy. These
innovative compounds aim to address the complex interplay of hormonal pathways
involve...
Source: Hormone and Metabolic Research - April 11, 2024 Category: Endocrinology Authors: Steenblock, Charlotte Saber-Ayad, Maha M. Bornstein, Stefan R. Tags: Editorial Source Type: research
Association Between Triglyceride Glucose Index with Cognitive
Impairment and Dementia in Adult Population: A Meta-Analysis
In conclusion, a
high TyG index may be associated with higher risk of cognitive impartment and
dementia in adult population. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 9, 2024 Category: Endocrinology Authors: Han, Yuqing Meng, Xu Wang, Dahui Tags: Original Article: Endocrine Care Source Type: research
Severity Identification of Graves Orbitopathy via Random Forest
Algorithm
In conclusion, this study
shows the potential for applying a random forest model as a complementary tool
to differentiate GO severity. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 8, 2024 Category: Endocrinology Authors: Wang, Minghui Li, Gongfei Dong, Li Hou, Zhijia Zhang, Ju Li, Dongmei Tags: Original Article: Endocrine Care Source Type: research
Cross-Talk Between Thyroid Disorders and Nonalcoholic Fatty Liver
Disease: From Pathophysiology to Therapeutics
Horm Metab Res DOI: 10.1055/a-2276-7973The medical community acknowledges the presence of thyroid disorders and
nonalcoholic fatty liver disease (NAFLD). Nevertheless, the interconnection
between these two circumstances is complex. Thyroid hormones (THs), including
triiodothyronine (T3) and thyroxine (T4), and thyroid-stimulating hormone (TSH),
are essential for maintaining metabolic balance and controlling the metabolism
of lipids and carbohydrates. The therapeutic potential of THs, especially those
that target the TRβ receptor isoform, is generating increasing ...
Source: Hormone and Metabolic Research - April 5, 2024 Category: Endocrinology Authors: Yang, Yan Xiao, Jiyuan Qiu, Wen Jiang, Luxia Tags: Review Source Type: research
Correlation Between TRAb and Early Onset Hypothyroidism After
131I Treatment for Graves ʼ Disease
This study was a retrospective observation,
including 226 patients who received the first 131I treatment. The
general information and laboratory tests were collected before and after
131I treatment, and the laboratory data affecting the difference
in disease outcome were analyzed. According to the changes of antibodies in the
third month, whether the changes of antibodies were involved in the occurrence
of early-onset hypothyroidism was analyzed. Early onset hypothyroidism occurred
in 165 of 226 patients, and the results showed that the incidence of ea...
Source: Hormone and Metabolic Research - April 4, 2024 Category: Endocrinology Authors: Song, Qi Fang, Zhouyu Wang, Shurong Liu, Zhihua Xiao, Wenjin Zong, Haijun Xie, Ying Tags: Original Article: Endocrine Care Source Type: research
A Retrospective Review on Dysregulated Autophagy in Polycystic Ovary
Syndrome: From Pathogenesis to Therapeutic Strategies
In conclusion,
autophagy disorder is a key pathological mechanism in PCOS and is also a
potential target for drug development and design. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - April 2, 2024 Category: Endocrinology Authors: Zhao, Yan Zhao, Xiaoxuan Jiang, Tianyue Xi, Hongyan Jiang, Yuepeng Feng, Xiaoling Tags: Review Source Type: research
Lipid Profile Evolution in Graves ’ Disease Treated with Titration
Regimen of Anti-Thyroid Drugs Versus Block and Replace Regimen
In this study were
included 149 medically treated GD patients, aged+>+18 years. Pregnant women
and patients treated with radioactive iodine therapy or partial/total
thyroidectomy were excluded. Patients were divided into 2 subgroups: titration
(A) and block and replace (B) therapy, according to the ATD regimen used.
Thyroid and metabolic profile was measured at baseline and at least one visit
during medical treatment. The whole group included 122 (81.87%) females (F) and
27 (18.12%) males (M), ratio F:M=4.5:1. As expected, at the time of diagnosis,
...
Source: Hormone and Metabolic Research - April 2, 2024 Category: Endocrinology Authors: Stancu, Ana-Maria Pop, Oana Purice, Mariana Badiu, Corin Tags: Original Article: Endocrine Care Source Type: research
The Pathophysiological Associations Between Obesity, NAFLD, and
Atherosclerotic Cardiovascular Diseases
Horm Metab Res DOI: 10.1055/a-2266-1503Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic
cardiovascular diseases are common and growing public health concerns. Previous
epidemiological studies unfolded the robust correlation between obesity, NAFLD,
and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor
for NAFLD, and both of them can markedly increase the odds of atherosclerotic
cardiovascular diseases. On the other hand, significant weight loss achieved by
lifestyle modification, bariatric surgery, or medications, s...
Source: Hormone and Metabolic Research - March 12, 2024 Category: Endocrinology Authors: Li, Meng Cui, Man Li, Guoxia Liu, Yueqiu Xu, Yunsheng Eftekhar, Seyed Parsa Ala, Moein Tags: Review Source Type: research
The Adrenal Gland and Pancreatic Islets – A Beneficial Endocrine
Alliance
Horm Metab Res DOI: 10.1055/a-2256-6344Intraportal islet transplantation in patients with type 1 diabetes enables
restoration of glucose-regulated insulin secretion. However, several factors
hamper a widespread application and long-term success: chronic hypoxia, an
inappropriate microenvironment and suppression of regenerative and proliferative
potential by high local levels of immunosuppressive agents. Therefore, the
identification of alternative and superior transplant sites is of major
scientific and clinical interest. Here, we aim to evaluate the adrenal as an...
Source: Hormone and Metabolic Research - March 12, 2024 Category: Endocrinology Authors: Schubert, Undine Lehmann, Susann Schmid, Janine Morawietz, Henning Bornstein, Stefan R. Ludwig, Barbara Tags: Original Article: Endocrine Research Source Type: research
Association of VEGF+936 C/T Polymorphism with Susceptibility to Type
2 Diabetic Retinopathy: A Meta-Analysis
In conclusion, the VEGF+936 C/T polymorphism significantly contributed
to the T2DR risk. Specifically, at the VEGF+936 C/T locus, the presence of
allele C and genotypes CC, CT, and CC+CT were found to be associated with a
reduced risk of T2DR. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - March 12, 2024 Category: Endocrinology Authors: Huo, Yanhong Zhang, Xin Su, Li Zhang, Yan Tags: Original Article: Endocrine Care Source Type: research
Recent Advances in Molecular Pathways and Therapeutic Implications
for Peptic Ulcer Management: A Comprehensive Review
Horm Metab Res DOI: 10.1055/a-2256-6592Peptic ulcers, recognized for their erosive impact on the gastrointestinal
mucosa, present a considerable challenge in gastroenterology. Epidemiological
insights underscore the global prevalence of peptic ulcers, affecting 5–10+% of
individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent
decades have witnessed a decline in complications, attributed to improved
diagnostics and therapeutic advancements. The review deepens into H.
pylori-associated and NSAID-induced ulcers, emphasizing their distinct
...
Source: Hormone and Metabolic Research - March 11, 2024 Category: Endocrinology Authors: Joshi, Deepak Chandra Joshi, Nirmal Kumar, Ajeet Maheshwari, Shubhrat Tags: Review Source Type: research
Dysregulation of miR-335-5p in People with Obesity and its Predictive
Value for Metabolic Syndrome
In conclusion, miR-335-5p holds predictive and
diagnostic value for obesity and metabolic syndrome and has potential to serve
as a biomarker for these conditions. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - March 6, 2024 Category: Endocrinology Authors: Liting, Lu Yufeng, He Tags: Original Article: Endocrine Research Source Type: research
Relationship Between Urinary Iodine Concentration and the Prevalence
of Thyroid Nodules and Subclinical Hypothyroidism
In conclusion,
iodine intake was sufficient in the Xi’an area, while the adults’ UIC remains
slightly higher than the criteria. Iodine excess or deficiency can lead to an
increase in the prevalence of subclinical hypothyroidism. Patients with iodine
deficiency are more likely to develop TNs. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - March 6, 2024 Category: Endocrinology Authors: Zhu, Huachao Chen, Pu Ding, Xi Zhao, Yanru Tags: Original Article: Endocrine Care Source Type: research
