AGA Clinical Practice Update on Pain Management in Inflammatory Bowel Disease: Commentary
Pain is a common symptom among patients with inflammatory bowel disease (IBD). Although pain typically occurs during episodes of inflammation, it is also commonly experienced when intestinal inflammation is quiescent. Many gastroenterologists are at a loss how to approach pain symptoms when they occur in the absence of gut inflammation. We provide guidance in this area as to the evaluation, diagnosis, and treatment of pain among patients with IBD. (Source: Gastroenterology)
Source: Gastroenterology - April 17, 2024 Category: Gastroenterology Authors: Laurie Keefer, Jana G. Hashash, Eva Szigethy, Emeran A. Mayer Tags: Clinical Practice Update Source Type: research
Presentation of the Julius M. Friedenwald Medal to M. Bishr Omary
We had the privilege to nominate and now celebrate M. Bishr Omary as the 2024 recipient of the American Gastroenterological Association (AGA) Julius M. Friedenwald Medal, named after AGA ’s 8th president. Bishr’s nomination was seconded by 11 co-signatories who are luminaries in our digestive health field as one measure of his standing in, and contributions to, our specialty. This recognition highlights his impactful and inspirational contributions to the AGA, and to our field o n so many levels, including his track record in academic and research accomplishments; leadership; mentorship; championing of diversity, equit...
Source: Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Anna S. Lok, John M. Inadomi Tags: AGA Section Source Type: research
Clinical presentation and spectrum of gluten symptomatology in celiac disease
Views on the clinical presentation and symptomatology of celiac disease have evolved alongside advances in disease detection and understanding of disease pathogenesis. While historically regarded a pediatric illness characterized by malabsorption, it is now better viewed as an immune illness of gluten-specific T cells with systemic manifestations affecting all ages. Its broad presentation, including frequent extraintestinal manifestations and asymptomatic disease, contributes to suboptimal disease detection. (Source: Gastroenterology)
Source: Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Dawn W. Adams, Stephanie Moleski, Jacqueline Jossen, Jason A. Tye-Din Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells
High expression of phosphatidylinositol 4-kinase III alpha (PI4KIII α) correlates with poor survival rates in patients with hepatocellular carcinoma (HCC). In addition, Hepatitis C virus (HCV) infections activate PI4KIIIα and contribute to HCC progression. We aimed at mechanistically understanding the impact of PI4KIIIα on the progression of liver cancer and the potential contribution of HCV in this process. (Source: Gastroenterology)
Source: Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Cong Si Tran, Julia Kersten, Jingyi Yan, Marco Breinig, Thorben Huth, Tanja Poth, Ombretta Colasanti, Tobias Riedl, Suzanne Faure-Dupuy, Stefan Diehl, Lieven Verhoye, Teng-Feng Li, Marit Lingemann, Philipp Schult, Gustaf Ahl én, Lars Frelin, Florian Küh Tags: Basic and Translational - Liver Source Type: research
Clearance of gut mucosal SARS-CoV-2 antigens and post-acute COVID-19 after two years in patients with inflammatory bowel disease
(Source: Gastroenterology)
Source: Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Andreas Zollner, Robert Koch, Almina Jukic, Alexandra Pfister, Moritz Meyer, Nikolaus Wick, Georg Wick, Annika R össler, Janine Kimpel, Timon E. Adolph, Herbert Tilg Tags: Research Letter Source Type: research
Unlocking the potential of fecal virome transplants (FVT): modulating the gut-brain axis in stress-related disorders
(Source: Gastroenterology)
Source: Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Chalystha Yie Qin Lee, Kara Gross Margolis Tags: Gastro Digest Source Type: research
An Unusual Cause of Cat Scratch Colon
(Source: Gastroenterology)
Source: Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Xiao Yan Ye, Yue Guan, Jie Yuan Tags: Electronic Gastro Curbside Consult Source Type: research
GLP1 receptor agonists and post-endoscopic aspiration pneumonia: what plays a role in clinical practice?
(Source: Gastroenterology)
Source: Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Hui Xu, Lianjun Lin Tags: Correspondence Source Type: research
Microbial metabolite: a link between psychological stress and epithelial disturbance
(Source: Gastroenterology)
Source: Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: David Reed Tags: Gastro Digest Source Type: research
How Future Pharmacologic Therapies for Celiac Disease Will Complement the Gluten-Free Diet
The only proven treatment for celiac disease is adherence to a strict, lifelong, gluten-free diet. However, complete dietary gluten avoidance is challenging and a substantial number of patients do not respond fully, clinically, or histologically, despite their best efforts. As celiac disease is common and its central pathophysiology is well elucidated, it has become attractive for drug development to address the limitations of dietary treatment. Most efforts address nonresponsive celiac disease, defined as continued symptoms and/or signs of disease activity despite a gluten-free diet, including the more severe forms of ref...
Source: Gastroenterology - April 9, 2024 Category: Gastroenterology Authors: Valentina Discepolo, Ciar án P. Kelly, Frits Koning, Detlef Schuppan Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Intestinal inflammation and extraintestinal disease: understanding dynamic risk
(Source: Gastroenterology)
Source: Gastroenterology - April 9, 2024 Category: Gastroenterology Authors: James J. Ashton, Jack Satsangi, Holm H. Uhlig Tags: Editorials Source Type: research
How future pharmacological therapies for celiac disease will complement the gluten-free diet
The only proven treatment for celiac disease is adherence to a strict, lifelong, gluten free diet. However, complete dietary gluten avoidance is challenging and a substantial number of patients do not respond fully, clinically or histologically, despite their best efforts. As celiac disease is common and its central pathophysiology is well elucidated, it has become attractive for drug development to address the limitations of dietary treatment. Most efforts address non-responsive celiac disease, defined as continued symptoms and/or signs of disease activity despite a gluten free diet, including the more severe forms of ref...
Source: Gastroenterology - April 9, 2024 Category: Gastroenterology Authors: Valentina Discepolo, Ciar án P. Kelly, Frits Koning, Detlef Schuppan Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Nutrition Assessment and Management in Celiac Disease
Celiac disease (CeD) is the most common immune condition affecting the gastrointestinal tract; it is triggered by gluten and the only available treatment is a strict gluten-free diet (GFD). Therefore, for patients with CeD, adopting a GFD is not a lifestyle choice. The major problem is that a GFD is restrictive and, like all restrictive diets, it has the potential for adverse nutritional outcomes, especially if adopted for a long term. It is well known that GFD can be nutritionally inadequate and is frequently associated with vitamin and mineral deficiencies; it is also associated with excessive sugar and fat intake, parti...
Source: Gastroenterology - April 6, 2024 Category: Gastroenterology Authors: M. Ines Pinto-Sanchez, Jedid-Jah Blom, Peter R. Gibson, David Armstrong Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Nutrition assessment and management in celiac disease.
CeD is the most common immune condition affecting the gastrointestinal tract; it is triggered by gluten and the only available treatment is a strict gluten-free diet (GFD). Therefore, for patients with CeD, adopting a GFD is not a lifestyle choice. The major problem is that a GFD is restrictive, and like all restrictive diets, it has the potential for adverse nutritional outcomes, especially if adopted for a long-term. It is well known that GFD can be nutritionally inadequate and is frequently associated with vitamin and mineral deficiencies; it is, also, associated with excessive sugar and fat intake, particularly when gl...
Source: Gastroenterology - April 6, 2024 Category: Gastroenterology Authors: M Ines Pinto-Sanchez, Jedid-Jah Blom, Peter R. Gibson, David Armstrong Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Intestinal motility may not be completely dependent on epithelial Ret signalling in the adult intestine
(Source: Gastroenterology)
Source: Gastroenterology - April 6, 2024 Category: Gastroenterology Authors: Faidra Karkala, Min Wang, Maria M. Alves, Kaushal Parikh Tags: Correspondence Source Type: research
