Editorial: Emerging aspects of ketone metabolism in health & disease
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - April 3, 2024 Category: Physiology Source Type: research
Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice
Discussion: Endogenous EPO has a protective effect on heart function. With EPO administration, in contrast to the protective effect to the cardiac injury of acute EPO treatment, extended EPO treatment to increase hematocrit in WT mice adversely affected the heart function with a corresponding increase in expression of heart failure-associated genes. This EPO activity was independent of EPO-stimulated erythropoiesis and required EPOR in non-erythroid tissue and nNOS activity, while nNOS−/− mice were protected from the EPO-associated adverse effect on heart function. These data provide evidence that nNOS contributes to t...
Source: Frontiers in Physiology - April 2, 2024 Category: Physiology Source Type: research
The effect of 10 weeks of karate training on the development of motor skills in children who are new to karate
In conclusion, the study shows that the 10-week karate training program positively affected the motor development of the participating children. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - April 2, 2024 Category: Physiology Source Type: research
A new perspective of frozen shoulder pathology; the interplay between the brain and the immune system
Frozen shoulder (FS), also known as adhesive capsulitis of the shoulder (FS), is a fibrotic inflammatory process of unknown etiology whose main symptoms are pain, stiffness and the loss of joint mobility. These symptoms may be associated with pathologies such as diabetes, Dupuytren’s syndrome and the prevalence of today’s sedentary lifestyle. This literature review provides an overview of the epidemiology and pathogenesis of this pathology, as well as the mechanisms of lowgrade chronic inflammation and infection, insulin resistance, and omics-science associated with it. We also propose a new hypothesis related to the p...
Source: Frontiers in Physiology - March 29, 2024 Category: Physiology Source Type: research
A prenatal acoustic signal of heat reduces a biomarker of chronic stress at adulthood across seasons
During development, phenotype can be adaptively modulated by environmental conditions, sometimes in the long-term. However, with weather variability increasing under climate change, the potential for maladaptive long-term responses to environmental variations may increase. In the arid-adapted zebra finch, parents emit “heat-calls” when experiencing heat during incubation, which adaptively affects offspring growth in the heat, and adult heat tolerance. This suggests that heat-call exposure may adjust individual phenotype to hot conditions, potentially compromising individual sensitivity to cool weather conditions. To te...
Source: Frontiers in Physiology - March 29, 2024 Category: Physiology Source Type: research
A jump in the atrioventricular conduction curve is not caused by a switch from fast pathway to slow pathway conduction
Conclusion: Contrary to what has been assumed, a transition from FP to SP conduction does not produce a jump in the AV conduction curve. A jump in the AV conduction curve is most likely caused by the formation of intranodal/nodal–atrial reentry and its subsequent conduction. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 29, 2024 Category: Physiology Source Type: research
Motor properties of Myosin 5c are modulated by tropomyosin isoforms and inhibited by pentabromopseudilin
We describe the purification and functional characterization of human Myo5c–HMM co–produced either with CaM alone or with CaM and the essential and regulatory light chains Myl6 and Myl12b. We describe the extent to which cofilaments of actin and Tpm1.6, Tpm1.8 or Tpm3.1 alter the maximum actin–activated ATPase and motile activity of the recombinant Myo5c constructs. The small allosteric effector pentabromopseudilin (PBP), which is predicted to bind in a groove close to the actin and nucleotide binding site with a calculated ΔG of −18.44 kcal/mol, inhibits the motor function of Myo5c with a half–maximal concentr...
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito
The mosquito Aedes aegypti is an important vector of diseases including dengue, Zika, chikungunya, and yellow fever. Olfaction is a critical modality for mosquitoes enabling them to locate hosts, sources of nectar, and sites for oviposition. GABA is an essential neurotransmitter in olfactory processing in the insect brain, including the primary olfactory center, the antennal lobe. Previous work with Ae. aegypti has suggested that antennal lobe inhibition via GABA may be involved in the processing of odors. However, little is known about GABA receptor expression in the mosquito brain, or how they may be involved in odor att...
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
Exploring the causal relationship between female reproductive traits and frailty: a two-sample mendelian randomization study
Conclusion: Our research has established a significant causal relationship between female reproductive traits (AFS, AFB, AAM) and frailty, with BMI and EA acting as mediating factors in this process. However, further research is warranted to validate our findings and elucidate the underlying biological mechanisms. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
Erratum: Microglial reactivity in brainstem chemosensory nuclei in response to hypercapnia
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
In vivo bistatic dual-aperture ultrasound imaging and elastography of the abdominal aorta
Conclusion: Multi-aperture ultrasound imaging and elastography is feasible in vivo and can provide the clinician with vital information about the anatomical and mechanical state of AAAs in the future. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
Corrigendum: Playing basketball and volleyball during adolescence is associated with higher bone mineral density in old age: the Bunkyo Health Study
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 27, 2024 Category: Physiology Source Type: research
The possible mechanisms of ferroptosis in sepsis-associated acquired weakness
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and its morbidity and mortality rates are increasing annually. It is an independent risk factor for intensive care unit-acquired weakness (ICU-AW), which is a common complication of patients in ICU. This situation is also known as sepsis-associated acquired weakness (SAW), and it can be a complication in more than 60% of patients with sepsis. The outcomes of SAW are often prolonged mechanical ventilation, extended hospital stays, and increased morbidity and mortality of patients in ICUs. The pathogenesis of SAW is unclear, a...
Source: Frontiers in Physiology - March 27, 2024 Category: Physiology Source Type: research
The oral contraceptive cycle and its influences on maximal and submaximal endurance parameters in elite handball players
The usage of the oral contraceptive pill is widespread among athletes of various levels. However, there is limited knowledge on how the intake of the pill alters the submaximal and maximal endurance parameters between the oral contraceptive phases. Therefore, the aim of this study was to examine potential differences between the pill intake and withdrawal phase on endurance-related parameters in first-division handball players. In total, 15 female team handball players performed two graded exercise tests until volitional exhaustion on a motorized treadmill. Tests were performed during the pill intake (days 16–17) and wit...
Source: Frontiers in Physiology - March 27, 2024 Category: Physiology Source Type: research
Effect of active and passive techniques used in thromboembolic prophylaxis on venous flow velocity in the post-procedure period
DiscussionAn elementary mathematical function can be used to estimate the time to recovery of peak venous flow velocity to resting state from measurements taken 15 min after the intervention. Active and passive mechanical thromboembolic prophylaxis after the intervention has a longer-term effect on venous flow velocity. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 27, 2024 Category: Physiology Source Type: research
