CDK4/6 inhibitors in drug-induced liver injury: a pharmacovigilance study of the FAERS database and analysis of the drug –gene interaction network
Conclusion:Our study revealed variations in hepatobiliary toxicity among the different CDK4/6 inhibitors, with ribociclib showing the highest risk of liver injury, followed by abemaciclib, while palbociclib appeared relatively safe. Our findings emphasize the need for cautious use of CDK4/6 inhibitors, and regular liver function monitoring is recommended for long-term CDK4/6 inhibitor use. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential
Conclusion: Vitekwangin B may offer a new direction for cancer therapy by targeting ANO1 protein, potentially improving treatment outcomes in patients with prostate cancer and NSCLC. Further research is needed to explore its full potential and overcome existing drug resistance challenges. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Anticancer activities of natural abietic acid
Cancer is the main cause of death in the world. There are several therapies that are in practice for cancer cure including radiotherapy, chemotherapy, and surgery. Among the chemotherapies, natural products are considered comparable safe, easily available and cost effective. Approximately 60% of cancer approved FDA drugs are natural products including vinblastine, doxorubicin, and paclitaxel. These natural products have complex structures due to which they work against cancer through different molecular pathways, STAT3, NF-kB, PI3K/AKT/mTOR, cell cycle arrest, mitochondrial dependent pathway, extrinsic apoptosis pathway, a...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Salvia miltiorrhiza ameliorates endometritis in dairy cows by relieving inflammation, energy deficiency and blood stasis
Conclusion: These results provide mechanistic understanding of the therapeutic effect of Salvia miltiorrhiza for endometritis achieved through Qi deficiency, blood stasis, and external evil invasion. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Effect of Celastrus Orbiculatus Extract on proliferation and apoptosis of human Burkitt lymphoma cells
This study aims to investigate the impact and underlying mechanisms of COE on the proliferation and apoptosis of Burkitt lymphoma cells. We diluted COE in RPMI-1640 medium to create various working concentrations and introduced it to human Burkitt lymphoma Raji and Ramos cells. To evaluate cell viability, we used the CCK-8 assay, and we observed morphological changes using HE staining. We also conducted Annexin V-PI and JC-1 staining experiments to assess apoptosis. By combining the cell cycle experiment with the EDU assay, we gained insights into the effects of COE on DNA replication in lymphoma cells. Using Western blott...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Wuhu decoction combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: a systematic review and meta analysis of randomized controlled trials
Conclusion: Based on our meta-analysis findings, the combined therapy of Wuhu Decoction and azithromycin for treating pediatric Mycoplasma pneumoniae pneumonia exhibited superior overall efficacy in comparison to azithromycin monotherapy. However, in the included 22 studies, the majority of evaluated factors showed unclear bias risks, and a persistent bias risk was consistently present within one category. Moreover, due to the low quality of evidence, interpreting these results should be approached with caution. Hence, we emphasize the necessity for future high-quality, multicenter, and large-sample clinical randomized con...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles
Adenylyl cyclases (ACs) are crucial effector enzymes that transduce divergent signals from upstream receptor pathways and are responsible for catalyzing the conversion of ATP to cAMP. The ten AC isoforms are categorized into four main groups; the class III or calcium-inhibited family of ACs comprises AC5 and AC6. These enzymes are very closely related in structure and have a paucity of selective activators or inhibitors, making it difficult to distinguish them experimentally. AC5 and AC6 are highly expressed in the heart and vasculature, as well as the spinal cord and brain; AC6 is also abundant in the lungs, kidney, and l...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis
Conclusion: Our findings elucidate the promising therapeutic potential of Chinese herbal medicines as viable alternatives in the treatment of depression, with certain herbs demonstrating enhanced efficacy and safety profiles. The outcomes of this study advocate for the integration of these alternative modalities into contemporary depression management paradigms. However, it underscores the necessity for larger, methodologically robust trials to further validate and refine these preliminary findings.Systematic review registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023452109. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
The traditional uses, pharmacology, and phytochemistry of Peucedanum praeruptorum Dunn
Bai Hua Qian Hu (Qianhu; Peucedanum praeruptorum Dunn) is a classical medicinal plant traditionally prescribed for respiratory ailments, including cough, pulmonary hypertension, and asthma. In this review, we summarize the research progress of the toxicology, pharmacokinetics, pharmacology, phytochemistry, botany, quality control, and traditional uses of P. praeruptorum in order to support future investigations into the scientific and therapeutic promise of this important medicinal plant. Information pertaining to P. praeruptorum was collected from scientific databases (ScienceDirect, Springer, SciFinder, PubMed, Baidu Sch...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Network pharmacology and molecular docking reveal the mechanisms of curcumin activity against esophageal squamous cell carcinoma
Conclusion: Collectively, these findings indicate that CUR exhibits pharmacological effects on multiple targets and pathways in ESCC. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Preschool children ’s asthma medication: parental knowledge, attitudes, practices, and adherence
This study aimed to analyze the KAP toward asthma medication and adherence among preschool-aged asthmatic children’s parents and explore the factors influencing adherence.Methods: This cross-sectional study was conducted between February 2023 and April 2023. Parents of preschool children with asthma were asked to complete the questionnaire containing knowledge, attitude, practice dimensions, and demographic characteristics. The Morisky Medication Adherence Scale (MMAS) was used to investigate adherence.Results: A total of 632 valid questionnaires (154 male and 478 female) were included. Parents showed moderate knowledge ...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Effect of molecular hydrogen, a novelly-established antioxidant, on the retinal degeneration of hereditary retinitis pigmentosa: an in-vivo study
Conclusion Different forms of H2 intervention (hydrogen-rich saline and hydrogen gas) had no obvious effects on the course of retinal degeneration in rd1 mice. The specific mechanism of photoreceptor degeneration in the hereditary RP mouse model may be different, requiring different medical interventions. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction
Conclusion: The current study demonstrated that CMD effectively attenuated bone impairments associated with DM in a STZ-induced DOP rat model, and the anti-DOP effects of CMD were associated with the modulation of netrin-1/DCC/UNC5B signal transduction. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 2, 2024 Category: Drugs & Pharmacology Source Type: research
A comprehensive review of the recent advances on predicting drug-target affinity based on deep learning
Accurate calculation of drug-target affinity (DTA) is crucial for various applications in the pharmaceutical industry, including drug screening, design, and repurposing. However, traditional machine learning methods for calculating DTA often lack accuracy, posing a significant challenge in accurately predicting DTA. Fortunately, deep learning has emerged as a promising approach in computational biology, leading to the development of various deep learning-based methods for DTA prediction. To support researchers in developing novel and highly precision methods, we have provided a comprehensive review of recent advances in pr...
Source: Frontiers in Pharmacology - April 2, 2024 Category: Drugs & Pharmacology Source Type: research
Inhibitory effect of natural compounds on quorum sensing system in Pseudomonas aeruginosa: a helpful promise for managing biofilm community
This article explores many facets of utilizing natural compounds to inhibit and eradicate P. aeruginosa biofilms. It also examines the techniques and protocols employed to enhance the effectiveness of these compounds. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 2, 2024 Category: Drugs & Pharmacology Source Type: research
