Cancer Vaccines: A Novel Revolutionized Approach to Cancer Therapy
AbstractOver the past few decades, there has been significant advancement in the field of tumor immunotherapy. For many years vaccination against infectious diseases have been available. On the other hand very few cancer vaccines have been approved for human use. Ideal Cancer vaccines are biological response modifier work by stimulating both humoral and cellular immunity while overcoming the immunological suppression found in tumor. Two types of cancer vaccine: Prophylactic and therapeutic cancer vaccines are recommended for clinical use of individuals. HPV and HBV vaccines are the two widely used preventive vaccine used f...
Source: Indian Journal of Clinical Biochemistry - March 15, 2024 Category: Biochemistry Source Type: research

Toripalimab: A Next Generation Designed Anti-PD-1 Antibody for Treatment of Nasopharyngeal Carcinoma
Toripalimab is a PD-1 targeting humanized IgG4 monoclonal antibody (mAb) that is currently under review by US Food and Drug Administration (FDA) for first-line treatment of nasopharyngeal carcinoma (NPC) in combination with chemotherapy. Currently approved PD-1 monoclonal antibodies (mAbs) have demonstrated significant clinical benefit particularly in patients with PD-L1 expressing tumors. However, in three multicenter on-going phase 3 trials (including NPC, Jupiter-02), toripalimab in combination with chemotherapy has demonstrated good clinical efficacy irrespective of the PD-L-1 status. (Source: International Journal of ...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N. Rajasekaran, S. Ravindranathan, X. Wang, D.J. Chin, S.Y. Tseng, S. Klakamp, K. Widmann, G. Young, B. Yu, V. Kapoor, V. Vexler, P. Keegan, S. Yao, S.D. Khare, T. LaVallee Tags: 260 Source Type: research

Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury
Cell Transplant. 2024 Jan-Dec;33:9636897241237049. doi: 10.1177/09636897241237049.ABSTRACTNeuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation 4-hydroxynonenal (4-HNE) and protein nitration 3-nitrotyrosine (3-NT) are often used as indicators of oxidative and nitrosative damage...
Source: Cell Transplantation - March 14, 2024 Category: Cytology Authors: Ya-Ni Huang Nigel H Greig Pen-Sen Huang Yung-Hsiao Chiang Alan Hoffer Chih-Hao Yang David Tweedie Ying Chen Ju-Chi Ou Jia-Yi Wang Source Type: research

Natural Products in the Modulation of Farnesoid X Receptor Against Nonalcoholic Fatty Liver Disease
Am J Chin Med. 2024 Mar 14:1-24. doi: 10.1142/S0192415X24500137. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a global health concern with a high prevalence and increasing economic burden, but official medicine remains unavailable. Farnesoid X receptor (FXR), a nuclear receptor member, is one of the most promising drug targets for NAFLD therapy that plays a crucial role in modulating bile acid, glucose, and lipid homeostasis, as well as inhibits hepatic inflammation and fibrosis. However, the rejection of the FXR agonist, obecholic acid, by the Food and Drug Administration for treating hepatic ...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Jing Wang Na Yang Yu Xu Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

O-Trifluoromethylation of Carboxylic Acids via the Formation and Activation of Acyloxy(phenyl)trifluoromethyl- λ < sup > 3 < /sup > -Iodanes
Angew Chem Int Ed Engl. 2024 Feb 27:e202400449. doi: 10.1002/anie.202400449. Online ahead of print.ABSTRACTHere we report the challenging O-trifluoromethylation of carboxylic acids via the formation and activation of acyloxy(phenyl)trifluoromethyl-λ3 -iodanes. The method provides an easy access to various potentially valuable and hitherto elusive trifluoromethyl carboxylic esters. A remarkably wide range of substrates with commonly encountered functional groups are compatible with this reaction, including aromatic and aliphatic carboxylic acids, as well as Food and Drug Administration (FDA) approved drugs and pharmaceutic...
Source: Angewandte Chemie - March 14, 2024 Category: Chemistry Authors: Hongye Zhu Chi Gao Ting Yu Cong Xu Mang Wang Source Type: research

Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury
Cell Transplant. 2024 Jan-Dec;33:9636897241237049. doi: 10.1177/09636897241237049.ABSTRACTNeuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation 4-hydroxynonenal (4-HNE) and protein nitration 3-nitrotyrosine (3-NT) are often used as indicators of oxidative and nitrosative damage...
Source: Cell Transplantation - March 14, 2024 Category: Cytology Authors: Ya-Ni Huang Nigel H Greig Pen-Sen Huang Yung-Hsiao Chiang Alan Hoffer Chih-Hao Yang David Tweedie Ying Chen Ju-Chi Ou Jia-Yi Wang Source Type: research

Natural Products in the Modulation of Farnesoid X Receptor Against Nonalcoholic Fatty Liver Disease
Am J Chin Med. 2024 Mar 14:1-24. doi: 10.1142/S0192415X24500137. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a global health concern with a high prevalence and increasing economic burden, but official medicine remains unavailable. Farnesoid X receptor (FXR), a nuclear receptor member, is one of the most promising drug targets for NAFLD therapy that plays a crucial role in modulating bile acid, glucose, and lipid homeostasis, as well as inhibits hepatic inflammation and fibrosis. However, the rejection of the FXR agonist, obecholic acid, by the Food and Drug Administration for treating hepatic ...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Jing Wang Na Yang Yu Xu Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury
Cell Transplant. 2024 Jan-Dec;33:9636897241237049. doi: 10.1177/09636897241237049.ABSTRACTNeuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation 4-hydroxynonenal (4-HNE) and protein nitration 3-nitrotyrosine (3-NT) are often used as indicators of oxidative and nitrosative damage...
Source: Cell Transplantation - March 14, 2024 Category: Cytology Authors: Ya-Ni Huang Nigel H Greig Pen-Sen Huang Yung-Hsiao Chiang Alan Hoffer Chih-Hao Yang David Tweedie Ying Chen Ju-Chi Ou Jia-Yi Wang Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol
DISCUSSION: Results will contribute critical information regarding menthol in cigarettes and e-cigarettes to inform regulatory policies that maximize reductions in cigarette smoking and reduce tobacco-related health disparities.TRIAL REGISTRATION: NCT05259566. Yale IRB protocol #2000032211, last approved 12/8/2023.PMID:38475757 | DOI:10.1186/s12888-024-05619-0 (Source: Cancer Control)
Source: Cancer Control - March 13, 2024 Category: Cancer & Oncology Authors: Krysten W Bold Akshika Sharma Angela Haeny Ralitza Gueorguieva Eugenia Buta Stephen Baldassarri Lauren Lempert Suchitra Krishnan-Sarin Stephanie O'Malley Source Type: research

Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t-distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8-fo...
Source: The Journal of Clinical Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yiming Cheng Shengnan Du Hongxiang Hu Xiaomin Wang Leon Carayannopoulos Yan Li Source Type: research

Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t-distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8-fo...
Source: The Journal of Clinical Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yiming Cheng Shengnan Du Hongxiang Hu Xiaomin Wang Leon Carayannopoulos Yan Li Source Type: research