Experimental and Translational Stroke Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hypoxia after stroke: a review of experimental and clinical evidence
ConclusionWhilst evidence for the use of supplemental oxygen therapy is currently lacking, it is vital to rapidly identify and treat all causes of hypoxia in the acute stroke patient, as a failure to will lead to poorer clinical outcomes. The full results of a large randomised trial looking at the use of supplemental oxygen therapy are currently pending. (Source: Experimental and Translational Stroke Medicine)
Source: Experimental and Translational Stroke Medicine - December 7, 2016 Category: Neurology Source Type: research

Therapeutic potential of the renin angiotensin system in ischaemic stroke
AbstractThe renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e. blood pressure (BP), blood volume regulation], and an independent brain RAS, which is involved in the regulation of many functions such as memory, central control of BP and metabolic functions. In general terms, the RAS consists of two opposing axes; the ‘classical axis’ mediated primarily by Angiotensin II (Ang II), and the ‘alternative axis’ mediated mainly by Angiotensin-(1–7) (Ang-(1–7)). An imbalance of these two opposing axes is thoug...
Source: Experimental and Translational Stroke Medicine - October 7, 2016 Category: Neurology Source Type: research

Pathophysiology and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting
AbstractCerebral hyperperfusion is a relatively rare syndrome with significant and potentially preventable clinical consequences. The pathophysiology of cerebral hyperperfusion syndrome (CHS) may involve dysregulation of the cerebral vascular system and hypertension, in the setting of increase in cerebral blood flow. The early recognition of CHS is important to prevent complications such as intracerebral hemorrhage. This review will focus on CHS following carotid endarterectomy and carotid artery stenting. We will discuss the typical clinical features of CHS, risk factors, pathophysiology, diagnostic modalities for detecti...
Source: Experimental and Translational Stroke Medicine - September 6, 2016 Category: Neurology Source Type: research

A pilot study evaluating the use of ABCD2 score in pre-hospital assessment of patients with suspected transient ischaemic attack: experience and lessons learned
ConclusionsIt is possible to identify, recruit and follow up patients with suspected TIA in the EMS setting. Training large numbers of EMS staff is required as exposure to TIA patients is infrequent. Significant insight was gained into the complexity of NHS research governance mechanisms in the UK. This knowledge will facilitate the planning of a future adequately powered study to validate the ABCD2 tool in a pre-hospital setting. (Source: Experimental and Translational Stroke Medicine)
Source: Experimental and Translational Stroke Medicine - August 20, 2016 Category: Neurology Source Type: research

Erratum to: Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke
(Source: Experimental and Translational Stroke Medicine)
Source: Experimental and Translational Stroke Medicine - June 14, 2016 Category: Neurology Source Type: research

Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke
ConclusionCandesartan induced pro-recovery effects are dependent on the presence of reperfusion. (Source: Experimental and Translational Stroke Medicine)
Source: Experimental and Translational Stroke Medicine - April 27, 2016 Category: Neurology Source Type: research

Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke
Conclusion Candesartan induced pro-recovery effects are dependent on the presence of reperfusion. (Source: Experimental and Translational Stroke Medicine)
Source: Experimental and Translational Stroke Medicine - April 26, 2016 Category: Neurology Source Type: research

Report on the 7th scientific meeting of the Association for the Advancement of Young Academics in Neurology (NEUROWIND e.V.) held in Motzen, Germany, October 30 –November 1, 2015
AbstractFrom October 30 –November 1, 2015, the 7th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Seventy doctoral students and postdocs from over 25 different groups working in German and Swiss University Hospitals or Research Institutes attended the meeting to discuss their latest experiments and find ings in the fields of neuroimmunology, neurodegeneration and neurovascular research. This meeting report summarizes the many diverse presentations and the new preclinical to clinical neurology research data that were shared by the participants at the meeting. (Source: Experimental and Translational Stroke Medicine)
Source: Experimental and Translational Stroke Medicine - March 16, 2016 Category: Neurology Source Type: research

Report on the 7th scientific meeting of the Association for the Advancement of Young Academics in Neurology (NEUROWIND e.V.) held in Motzen, Germany, October 30–November 1, 2015
Abstract From October 30–November 1, 2015, the 7th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Seventy doctoral students and postdocs from over 25 different groups working in German and Swiss University Hospitals or Research Institutes attended the meeting to discuss their latest experiments and findings in the fields of neuroimmunology, neurodegeneration and neurovascular research. This meeting report summarizes the many diverse presentations and the new preclinical to clinical neurology research data that were shared by the participants at the meeting. (Source: Experimental and ...
Source: Experimental and Translational Stroke Medicine - March 16, 2016 Category: Neurology Source Type: research

Cerebral collateral circulation in experimental ischemic stroke
AbstractCerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several methods may be used for assessing cerebral collaterals in the acute phase of ischemic stroke in humans and rodents, they are generally underutilized. Experimental stroke models may play a unique role in understanding the adaptive response of cerebral collaterals during ischemia and their potential for therapeutic modulation. The systematic assessment of collateral perfusion in experimental stroke models may be us...
Source: Experimental and Translational Stroke Medicine - March 1, 2016 Category: Neurology Source Type: research