Experimental and Therapeutic Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of 23 ‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action
In conclusion, Pulsatilla compounds were indicated to inhibit the viability and proliferation of lung adenocarcinoma H1299 cells, and the mechanism of action was related to PPAR-γ, the PPAR signaling pathway and mitochondrial ROS. The present study provides novel insight to further explore the treatment of lung adenocarcinoma.PMID:38633355 | PMC:PMC11019653 | DOI:10.3892/etm.2024.12527 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 18, 2024 Category: General Medicine Authors: Boyu Tan Xiaoxu Lan Yifan Zhang Pai Liu Qiyao Jin Zhiqiang Wang Zhidong Liang Wei Song Ye Xuan Yunxiao Sun Youjie Li Source Type: research

[Retracted] The AMPK ‑mTOR axis requires increased MALAT1 expression for promoting granulosa cell proliferation in endometriosis
Exp Ther Med. 2024 Apr 2;27(6):240. doi: 10.3892/etm.2024.12528. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.9453.].PMID:38633356 | PMC:PMC11019655 | DOI:10.3892/etm.2024.12528 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 18, 2024 Category: General Medicine Authors: Xuejie Liu Ping Zhang Yanmin Li Na Zhao Haiyan Han Source Type: research

Icariin ‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling
Exp Ther Med. 2024 Mar 26;27(5):232. doi: 10.3892/etm.2024.12519. eCollection 2024 May.ABSTRACTFerroptosis is a form of regulatory cell death that relies on iron and reactive oxygen species (ROS) to inhibit tumors. The present study aimed to investigate whether icariin-curcumol could be a novel ferroptosis inducer in tumor inhibition. Various concentrations of icariin-curcumol were used to stimulate prostate cell lines (RWPE-2, PC-3, VCAP and DU145). Small interfering negative control (si-NC) and si-nuclear factor erythroid 2-related factor 2 (Nrf2) were used to transfect DU145 cells. Cell viability was determined by using...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Wen Sheng Bonan Li Tiansong Sun Congxu Zhu Yingqiu Li Wenjing Xu Source Type: research

New treatment strategies for uterine sarcoma using secreted frizzled ‑related proteins
In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.PMID:38628655 | PMC:PMC11019650 | DOI:10.3892/etm.2024.12520 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tomohiro Kagawa Ayuka Mineda Tomotaka Nakagawa Ayaka Shinohara Ryosuke Arakaki Hiroaki Inui Hiroki Noguchi Atsuko Yoshida Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Masato Nishimura Takeshi Iwasa Source Type: research

Deep lymph node enlargement and renal failure caused by hypercalcemia ‑associated sarcoidosis: A case report
Exp Ther Med. 2024 Mar 27;27(5):235. doi: 10.3892/etm.2024.12524. eCollection 2024 May.ABSTRACTSarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32-year-old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lym...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Zezhou Liu Zhigang Tang Jingping Yuan Ke Su Yonghong Jian Hongyan Liu Source Type: research

Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis
In conclusion, NONHSAG037054.2 and GABPA are associated with AS. GABPA was downregulated in AS, and it could serve as a novel diagnostic factor for AS.PMID:38628657 | PMC:PMC11019654 | DOI:10.3892/etm.2024.12525 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Penglei Cui Yanzhuo Zhang Chao Wang Bin Xiao Qianqian Wang Liang Zhang Hongchao Li Chengai Wu Wei Tian Source Type: research

Selected markers of ovarian cancer and their relation to targeted therapy (Review)
Exp Ther Med. 2024 Mar 27;27(5):236. doi: 10.3892/etm.2024.12523. eCollection 2024 May.ABSTRACTDespite advances in surgical treatment techniques and chemotherapy-including anti-angiogenic and immune poly (ADP-ribose) polymerase inhibitors, the 5-year survival rate in ovarian cancer (OC) remains low. The reasons for this are the diagnosis of cancer in advanced clinical stages, chemoresistance and cancer recurrence. New therapeutic approaches are being developed, including the search for new biomarkers that are also targets for targeted therapy. The present review describes new molecular markers with relevance to targeted th...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Anna Markowska Zbigniew Kojs Damian Twardawa Joanna Pietras Janina Markowska Source Type: research

Vasculitis and infectious risk in a patient with type 2 diabetes mellitus: A case report
Exp Ther Med. 2024 Mar 27;27(5):234. doi: 10.3892/etm.2024.12522. eCollection 2024 May.ABSTRACTThe connection between vasculitis and infection is complex. The present study described a typical situation for a patient with unbalanced type 2 diabetes and chronic complications, in which a lack of adherence to the protection and care measures ultimately led to the appearance of some of the worst consequences of the condition, namely, ulceration, gangrene and amputation. In the context of an unstable condition with significant metabolic imbalance there was an impaired response to infections in the present patient, and the amput...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Roxana M ădălina Mitroi Maria Magdalena Ro șu Diana Clenciu Vlad P ădureanu Adina Mitrea Maria Andreea Grigore Emilia Roxana Mazilu Dumitru R ădulescu Ionela Mihaela Vladu Source Type: research

Investigation of autophagy ‑related genes and immune infiltration in calcific aortic valve disease: A bioinformatics analysis and experimental validation
Exp Ther Med. 2024 Mar 26;27(5):233. doi: 10.3892/etm.2024.12521. eCollection 2024 May.ABSTRACTThe present study aimed to elucidate the role of autophagy-related genes (ARGs) in calcific aortic valve disease (CAVD) and their potential interactions with immune infiltration via experimental verification and bioinformatics analysis. A total of three microarray datasets (GSE12644, GSE51472 and GSE77287) were obtained from the Gene Expression Omnibus database, and gene set enrichment analysis was performed to identify the relationship between autophagy and CAVD. After differentially expressed genes and differentially expressed ...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Tie Hu Ying Jiang Jue-Sheng Yang Fa-Jia Hu Yong Yuan Ji-Chun Liu Li-Jun Wang Source Type: research

A prospective analysis of the efficacy of phase II autologous skin grafting on deep second ‑degree burns on the dorsum of the hand
Exp Ther Med. 2024 Mar 27;27(5):238. doi: 10.3892/etm.2024.12526. eCollection 2024 May.ABSTRACTThe aim of the present study was to investigate the possibility of reducing the damage to the donor site while preserving the functional recovery of the dorsum of the hand following burn injury. An attempt was made to analyze the effect of a phased surgery approach on inflammatory indicators. A two-phase treatment was administered on a total of 64 patients with deep second-degree burns on the dorsum of the hand who were admitted to Guangzhou Red Cross Hospital between January 2020 and March 2023. During phase I treatment, the wou...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Jing'en Sun Siman Su Songsong Jiao Gang Li Zhi Zhang Weihua Lin Shuyao Zhang Source Type: research