Experimental and Molecular Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research