Synergistic effects of using sodium hypochlorite (bleach) and desiccation in surface inactivation for Toxocara spp
Exp Parasitol. 2024 Apr 13:108753. doi: 10.1016/j.exppara.2024.108753. Online ahead of print.ABSTRACTToxocara cati and T. canis are parasitic nematodes found in the intestines of cats and dogs respectively, with a cosmopolitan distribution, and the potential for anthropozoonotic transmission, resulting in human toxocariasis. Spread of Toxocara spp. is primarily through the ingestion of embryonated eggs contaminating surfaces or uncooked food, or through the ingestion of a paratenic host containing a third-stage larva. The Toxocara spp. eggshell is composed of a lipid layer providing a permeability barrier, a chitinous laye...
Source: Experimental Parasitology - April 15, 2024 Category: Parasitology Authors: Janice L Liotta Alexandra Helfer Lucy Huang Timothy Wu Dwight D Bowman Carlo Castillo Hussni O Mohammed Bryant S Blank Source Type: research
Enteropathogenic Escherichia coli modulates the virulence and pathogenicity of Entamoeba dispar
Exp Parasitol. 2024 Apr 11:108750. doi: 10.1016/j.exppara.2024.108750. Online ahead of print.ABSTRACTAmoebiasis is a disease caused by Entamoeba histolytica, affecting the large intestine of humans and occasionally leading to extra-intestinal lesions. Entamoeba dispar is another amoeba species considered commensal, although it has been identified in patients presenting with dysenteric and nondysenteric colitis, as well as amoebic liver abscess. Amoebic virulence factors are essential for the invasion and development of lesions. There is evidence showing that the association of enterobacteria with trophozoites contributes t...
Source: Experimental Parasitology - April 13, 2024 Category: Parasitology Authors: Cezar Augusto Vilela da Silva Carlos Eduardo Costa Dos Santos Mariana Fernandes de Paula Cortezzi C ésar da Silva Santana Moura Ruth Elizabeth Cruz Camila de Almeida Lopes Karen Costa Lucas Teixeira de Souza Patr ícia Costa Lima da Silva Elisabeth Neuma Source Type: research
Enteropathogenic Escherichia coli modulates the virulence and pathogenicity of Entamoeba dispar
Exp Parasitol. 2024 Apr 11:108750. doi: 10.1016/j.exppara.2024.108750. Online ahead of print.ABSTRACTAmoebiasis is a disease caused by Entamoeba histolytica, affecting the large intestine of humans and occasionally leading to extra-intestinal lesions. Entamoeba dispar is another amoeba species considered commensal, although it has been identified in patients presenting with dysenteric and nondysenteric colitis, as well as amoebic liver abscess. Amoebic virulence factors are essential for the invasion and development of lesions. There is evidence showing that the association of enterobacteria with trophozoites contributes t...
Source: Experimental Parasitology - April 13, 2024 Category: Parasitology Authors: Cezar Augusto Vilela da Silva Carlos Eduardo Costa Dos Santos Mariana Fernandes de Paula Cortezzi C ésar da Silva Santana Moura Ruth Elizabeth Cruz Camila de Almeida Lopes Karen Costa Lucas Teixeira de Souza Patr ícia Costa Lima da Silva Elisabeth Neuma Source Type: research
Helminth-induced impairment of humoral immunity differently contribute to their anti-arthritic effects in mice: Comparison of Schistosoma mansoni and Trichinella spiralis
CONCLUSION: The down-modulations of anti-IIC IgG levels by the two parasitic infections and the correlation analyses suggest that the anti-arthritic activity of Sm was primarily attributed to the modulation of IgG-independent arthritogenic mechanisms and secondarily to the impairment of anti-IIC IgG production. In contrast, Ts could alleviate CIA mainly via reduction of antibody productions.PMID:38604301 | DOI:10.1016/j.exppara.2024.108752 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 11, 2024 Category: Parasitology Authors: Yoshio Osada Shoichi Shimizu Kentaro Morita Eman M Gaballah Zhiliang Wu Yoichi Maekawa Source Type: research
The response of Anisakis simplex (s. s.) to anthelmintics - Specific changes in xenobiotic metabolic processes
Exp Parasitol. 2024 Apr 9;261:108751. doi: 10.1016/j.exppara.2024.108751. Online ahead of print.ABSTRACTAnisakiasis is a parasitic disease transmitted through the consumption of raw or undercooked fish and cephalopods that are infected with larvae of Anisakis simplex (sensu stricto) or Anisakis pegreffii. The purpose of this study was to investigate how A. simplex (s. s.) responds to the influence of anthelmintics such as ivermectin (IVM) and pyrantel (PYR). In vitro experiments were conducted using larvae at two developmental stages of A. simplex (s. s.) (L3 and L4) obtained from Baltic herring (Clupea harengus membras). ...
Source: Experimental Parasitology - April 11, 2024 Category: Parasitology Authors: Robert Stryi ński Iwona Polak Anna Gawryluk Pawe ł Rosa El żbieta Łopieńska-Biernat Source Type: research
Helminth-induced impairment of humoral immunity differently contribute to their anti-arthritic effects in mice: Comparison of Schistosoma mansoni and Trichinella spiralis
CONCLUSION: The down-modulations of anti-IIC IgG levels by the two parasitic infections and the correlation analyses suggest that the anti-arthritic activity of Sm was primarily attributed to the modulation of IgG-independent arthritogenic mechanisms and secondarily to the impairment of anti-IIC IgG production. In contrast, Ts could alleviate CIA mainly via reduction of antibody productions.PMID:38604301 | DOI:10.1016/j.exppara.2024.108752 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 11, 2024 Category: Parasitology Authors: Yoshio Osada Shoichi Shimizu Kentaro Morita Eman M Gaballah Zhiliang Wu Yoichi Maekawa Source Type: research
The response of Anisakis simplex (s. s.) to anthelmintics - Specific changes in xenobiotic metabolic processes
Exp Parasitol. 2024 Apr 9;261:108751. doi: 10.1016/j.exppara.2024.108751. Online ahead of print.ABSTRACTAnisakiasis is a parasitic disease transmitted through the consumption of raw or undercooked fish and cephalopods that are infected with larvae of Anisakis simplex (sensu stricto) or Anisakis pegreffii. The purpose of this study was to investigate how A. simplex (s. s.) responds to the influence of anthelmintics such as ivermectin (IVM) and pyrantel (PYR). In vitro experiments were conducted using larvae at two developmental stages of A. simplex (s. s.) (L3 and L4) obtained from Baltic herring (Clupea harengus membras). ...
Source: Experimental Parasitology - April 11, 2024 Category: Parasitology Authors: Robert Stryi ński Iwona Polak Anna Gawryluk Pawe ł Rosa El żbieta Łopieńska-Biernat Source Type: research
Evaluation of bromocriptine and plumbagin against the monogenean Rhabdosynochus viridisi: Computational drug repositioning and in vitro approaches
Exp Parasitol. 2024 Apr 7;261:108748. doi: 10.1016/j.exppara.2024.108748. Online ahead of print.ABSTRACTMonogeneans are parasitic platyhelminths that can harm the health of farmed fish. Few treatments are available against monogeneans, and the incentive to develop new antiparasitic agents is similar or even lower than the incentive for neglected parasitic diseases in humans. Considering that searching for and developing new antimonogenean compounds may require enormous investments of time, money, and animal sacrifice, the use of a computer-guided drug repositioning approach is a reasonable alternative. Under this context, ...
Source: Experimental Parasitology - April 9, 2024 Category: Parasitology Authors: V íctor Hugo Caña-Bozada Alejandra Garc ía-Gasca Juan M Mart ínez-Brown F Neptal í Morales-Serna Source Type: research
Trypanosoma cruzi killing and immune response boosting by novel phenoxyhydrazine-thiazole against Chagas disease
Exp Parasitol. 2024 Apr 7;261:108749. doi: 10.1016/j.exppara.2024.108749. Online ahead of print.ABSTRACTTrypanosoma cruzi (T. cruzi) causes Chagas, which is a neglected tropical disease (NTD). WHO estimates that 6 to 7 million people are infected worldwide. Current treatment is done with benznidazole (BZN), which is very toxic and effective only in the acute phase of the disease. In this work, we designed, synthesized, and characterized thirteen new phenoxyhydrazine-thiazole compounds and applied molecular docking and in vitro methods to investigate cell cytotoxicity, trypanocide activity, nitric oxide (NO) production, cel...
Source: Experimental Parasitology - April 9, 2024 Category: Parasitology Authors: Ana Catarina Cristov ão-Silva Maria Carolina Accioly Brelaz-de-Castro Elis Dionisio da Silva Ana Cristina Lima Leite Lizandra Beatriz Amorim Alves Santiago Juliana Maria da Concei ção Robert da Silva Tiburcio Davi Pereira de Santana Danilo Cesar Galind Source Type: research
Evaluation of bromocriptine and plumbagin against the monogenean Rhabdosynochus viridisi: Computational drug repositioning and in vitro approaches
Exp Parasitol. 2024 Apr 7:108748. doi: 10.1016/j.exppara.2024.108748. Online ahead of print.ABSTRACTMonogeneans are parasitic platyhelminths that can harm the health of farmed fish. Few treatments are available against monogeneans, and the incentive to develop new antiparasitic agents is similar or even lower than the incentive for neglected parasitic diseases in humans. Considering that searching for and developing new antimonogenean compounds may require enormous investments of time, money, and animal sacrifice, the use of a computer-guided drug repositioning approach is a reasonable alternative. Under this context, this...
Source: Experimental Parasitology - April 9, 2024 Category: Parasitology Authors: V íctor Hugo Caña-Bozada Alejandra Garc ía-Gasca Juan M Mart ínez-Brown F Neptal í Morales-Serna Source Type: research
Trypanosoma cruzi killing and immune response boosting by novel phenoxyhydrazine-thiazole against Chagas disease
Exp Parasitol. 2024 Apr 7;261:108749. doi: 10.1016/j.exppara.2024.108749. Online ahead of print.ABSTRACTTrypanosoma cruzi (T. cruzi) causes Chagas, which is a neglected tropical disease (NTD). WHO estimates that 6 to 7 million people are infected worldwide. Current treatment is done with benznidazole (BZN), which is very toxic and effective only in the acute phase of the disease. In this work, we designed, synthesized, and characterized thirteen new phenoxyhydrazine-thiazole compounds and applied molecular docking and in vitro methods to investigate cell cytotoxicity, trypanocide activity, nitric oxide (NO) production, cel...
Source: Experimental Parasitology - April 9, 2024 Category: Parasitology Authors: Ana Catarina Cristov ão-Silva Maria Carolina Accioly Brelaz-de-Castro Elis Dionisio da Silva Ana Cristina Lima Leite Lizandra Beatriz Amorim Alves Santiago Juliana Maria da Concei ção Robert da Silva Tiburcio Davi Pereira de Santana Danilo Cesar Galind Source Type: research
Evaluation of bromocriptine and plumbagin against the monogenean Rhabdosynochus viridisi: Computational drug repositioning and in vitro approaches
Exp Parasitol. 2024 Apr 7:108748. doi: 10.1016/j.exppara.2024.108748. Online ahead of print.ABSTRACTMonogeneans are parasitic platyhelminths that can harm the health of farmed fish. Few treatments are available against monogeneans, and the incentive to develop new antiparasitic agents is similar or even lower than the incentive for neglected parasitic diseases in humans. Considering that searching for and developing new antimonogenean compounds may require enormous investments of time, money, and animal sacrifice, the use of a computer-guided drug repositioning approach is a reasonable alternative. Under this context, this...
Source: Experimental Parasitology - April 9, 2024 Category: Parasitology Authors: V íctor Hugo Caña-Bozada Alejandra Garc ía-Gasca Juan M Mart ínez-Brown F Neptal í Morales-Serna Source Type: research
Trypanosoma cruzi Killing and Immune Response Boosting by Novel Phenoxyhydrazine-Thiazole against Chagas Disease
Exp Parasitol. 2024 Apr 7:108749. doi: 10.1016/j.exppara.2024.108749. Online ahead of print.ABSTRACTTrypanosoma cruzi (T. cruzi) causes Chagas, which is a neglected tropical disease (NTD). WHO estimates that 6 to 7 million people are infected worldwide. Current treatment is done with benznidazole (BZN), which is very toxic and effective only in the acute phase of the disease. In this work, we designed, synthesized, and characterized thirteen new phenoxyhydrazine-thiazole compounds and applied molecular docking and in vitro methods to investigate cell cytotoxicity, trypanocide activity, nitric oxide (NO) production, cell de...
Source: Experimental Parasitology - April 9, 2024 Category: Parasitology Authors: Ana Catarina Cristov ão-Silva Maria Carolina Accioly Brelaz-de-Castro Elis Dionisio da Silva Ana Cristina Lima Leite Lizandra Beatriz Amorim Alves Santiago Juliana Maria da Concei ção Robert da Silva Tiburcio Davi Pereira de Santana Danilo Cesar Galind Source Type: research
Elucidating miR-146a-3p as a key player in autophagy and lipid metabolism in Leishmania major infection
Exp Parasitol. 2024 Mar 21;260:108745. doi: 10.1016/j.exppara.2024.108745. Online ahead of print.ABSTRACTAutophagy is a key step involved in many unicellular eukaryotic diseases, including leishmaniasis, for cellular remodelling and differentiation during parasite's lifecycle. Lipids play a significant role in the infection process that begins with Leishmania major invading host cells. MicroRNAs (miRNAs), a family of small, 22-24 nucleotide noncoding regulatory RNAs, target mRNAs to modify gene expression and, subsequently, proteome output may have a regulatory role in altering the host cell processes. We observed miR-146a...
Source: Experimental Parasitology - March 23, 2024 Category: Parasitology Authors: Prajakta Ingale Shailza Singh Source Type: research
Elucidating miR-146a-3p as a key player in autophagy and lipid metabolism in Leishmania major infection
Exp Parasitol. 2024 Mar 21;260:108745. doi: 10.1016/j.exppara.2024.108745. Online ahead of print.ABSTRACTAutophagy is a key step involved in many unicellular eukaryotic diseases, including leishmaniasis, for cellular remodelling and differentiation during parasite's lifecycle. Lipids play a significant role in the infection process that begins with Leishmania major invading host cells. MicroRNAs (miRNAs), a family of small, 22-24 nucleotide noncoding regulatory RNAs, target mRNAs to modify gene expression and, subsequently, proteome output may have a regulatory role in altering the host cell processes. We observed miR-146a...
Source: Experimental Parasitology - March 23, 2024 Category: Parasitology Authors: Prajakta Ingale Shailza Singh Source Type: research
