The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
CONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.PMID:38527636 | DOI:10.1016/j.exger.2024.112410 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 25, 2024 Category: Geriatrics Authors: Robert G Memelink Rose Njemini Minse J J de Bos Kuil Suzan Wopereis Johan de Vogel-van den Bosch Josje D Schoufour Michael Tieland Peter J M Weijs Ivan Bautmans Source Type: research

The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
CONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.PMID:38527636 | DOI:10.1016/j.exger.2024.112410 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 25, 2024 Category: Geriatrics Authors: Robert G Memelink Rose Njemini Minse J J de Bos Kuil Suzan Wopereis Johan de Vogel-van den Bosch Josje D Schoufour Michael Tieland Peter J M Weijs Ivan Bautmans Source Type: research

Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway
In conclusion, CZTL may alleviate neuroinflammation induced by CCH and improve cognitive impairment in CCH mice by regulating the cholinergic anti-inflammatory pathway (CAIP) involving ChAT/α7nAChR/NF-κB.PMID:38522309 | DOI:10.1016/j.exger.2024.112407 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Zhiyuan Wang Bin Han Jianjiao Qi Xuelei Cao Huali Gu Jinping Sun Source Type: research

Microbiome interactions with different risk factors in development of myocardial infarction
Exp Gerontol. 2024 Mar 22:112409. doi: 10.1016/j.exger.2024.112409. Online ahead of print.ABSTRACTAmong all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites. Host genetic factors...
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Manisha Bijla Sunil Kumar Saini Ajai Pathak Kamal Prakash Bharadwaj Katyayani Sukhavasi Ayurshi Patil Diksha Saini Rakesh Yadav Shalini Singh Christiaan Leeuwenburgh Pramod Kumar Source Type: research

Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway
In conclusion, CZTL may alleviate neuroinflammation induced by CCH and improve cognitive impairment in CCH mice by regulating the cholinergic anti-inflammatory pathway (CAIP) involving ChAT/α7nAChR/NF-κB.PMID:38522309 | DOI:10.1016/j.exger.2024.112407 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Zhiyuan Wang Bin Han Jianjiao Qi Xuelei Cao Huali Gu Jinping Sun Source Type: research

Microbiome interactions with different risk factors in development of myocardial infarction
Exp Gerontol. 2024 Mar 22:112409. doi: 10.1016/j.exger.2024.112409. Online ahead of print.ABSTRACTAmong all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites. Host genetic factors...
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Manisha Bijla Sunil Kumar Saini Ajai Pathak Kamal Prakash Bharadwaj Katyayani Sukhavasi Ayurshi Patil Diksha Saini Rakesh Yadav Shalini Singh Christiaan Leeuwenburgh Pramod Kumar Source Type: research

Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice
CONCLUSIONS: The present study revealed the ameliorative effects of eldecalcitol on senescence and the associated ferroptosis of osteocytes, contributing to its preservation against osteoporosis of D-gal-induced senescent ovariectomized mice.PMID:38521178 | DOI:10.1016/j.exger.2024.112408 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 23, 2024 Category: Geriatrics Authors: Yong-Fang Fu Yi-Xun Guo Shi-Hui Xia Ting-Ting Zhou Yun-Chao Zhao Zhen-Hua Jia Yan Zhang Source Type: research

Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research

Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research

Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research

Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research

Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
CONCLUSION: Remazolam affects the phenotype and function of astrocytes to improve TBI via regulating Cx43, and plays a role in protecting the neurological function of TBI rats.PMID:38492656 | DOI:10.1016/j.exger.2024.112404 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 16, 2024 Category: Geriatrics Authors: Jing Xia Yang Tan Congli Mao Wenting Shen Ying Zhao Source Type: research

Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
CONCLUSION: Remazolam affects the phenotype and function of astrocytes to improve TBI via regulating Cx43, and plays a role in protecting the neurological function of TBI rats.PMID:38492656 | DOI:10.1016/j.exger.2024.112404 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 16, 2024 Category: Geriatrics Authors: Jing Xia Yang Tan Congli Mao Wenting Shen Ying Zhao Source Type: research

Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
CONCLUSION: Remazolam affects the phenotype and function of astrocytes to improve TBI via regulating Cx43, and plays a role in protecting the neurological function of TBI rats.PMID:38492656 | DOI:10.1016/j.exger.2024.112404 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 16, 2024 Category: Geriatrics Authors: Jing Xia Yang Tan Congli Mao Wenting Shen Ying Zhao Source Type: research

Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults
This study lays the groundwork for using the OBVIO task in future assessment and intervention studies.PMID:38490285 | DOI:10.1016/j.exger.2024.112403 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Steven P Winesett Sudeshna A Chatterjee Brianne Borgia Brigette A Cox Kelly A Hawkins Jon W Miles Clayton W Swanson Julia T Choi Rachael D Seidler Emily J Fox David J Clark Source Type: research