Involvement of gut microbiota recovery and autophagy induction in Youhua Kuijie Formula's protection against experimental ulcerative colitis
Exp Anim. 2024 Apr 9. doi: 10.1538/expanim.23-0166. Online ahead of print.ABSTRACTUlcerative colitis (UC) is characterized by overactive inflammatory response, impaired intestinal mucosal barrier and disrupted gut microbiota. Youhua Kuijie formula is a classic empirical prescription based on the pathogenesis of UC. The present study was designed to verify the protective effect of Youhua Kuijie Formula on DSS-induced UC in mice and uncover the related mechanism. Youhua Kuijie Formula were orally administrated to UC mice induced by DSS dissolved in drinking water for ten days. The protective effect of Youhua Kuijie Formula w...
Source: Experimental Animals - April 10, 2024 Category: Research Authors: Tianjiao Sheng Lei Wang Simeng Yan Qiuyu Wei Xiao Geng Weiru Lan Yan Chen Yuedong Liu Na Li Source Type: research
Myelin lesion in the aspartoacylase (Aspa) knockout rat, an animal model for Canavan disease
Exp Anim. 2024 Mar 28. doi: 10.1538/expanim.23-0089. Online ahead of print.ABSTRACTCanavan disease (CD) is a fatal hereditary neurological disorder caused by a mutation in the aspartoacylase (ASPA) gene and characterized by neurological signs and vacuolation in the central nervous system (CNS). The mutation inhibits the hydrolysis of N-acetyl-aspartate (NAA) resulting in accumulation of NAA in the CNS. A new Aspa-knockout rat was generated by transcription activator-like effector nuclease (TALEN) technology. Herein we describe the pathological and morphometrical findings in the brain and spinal cords of Aspa-knockout rats....
Source: Experimental Animals - March 27, 2024 Category: Research Authors: Shuji Takeda Rika Hoshiai Miyuu Tanaka Takeshi Izawa Jyoji Yamate Takashi Kuramoto Mitsuru Kuwamura Source Type: research
