Interaction between baseline BMI and baseline disease severity predicts greater improvement in negative symptoms in first-episode schizophrenia
This study aimed to evaluate whether baseline body mass index (BMI) and disease severity were associated with improvements in negative symptoms in patients with first-episode and medication-na ïve (FEMN) SCZ. A total of 241 FEMN patients were recruited in this study and treated with oral risperidone over 3 months. Clinical symptoms were measured by the Positive and Negative Syndrome Scale (PANSS) and BMI was assessed at baseline and 3-month follow-up. We found that baseline BMI was corr elated with the baseline severity of symptoms. Baseline BMI or baseline disease severity was associated with improvement in negative sym...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 27, 2024 Category: Neuroscience Source Type: research

Childhood abuse and craving in methamphetamine-dependent individuals: the mediating role of alexithymia
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 26. doi: 10.1007/s00406-024-01775-2. Online ahead of print.ABSTRACTIndividuals with a history of childhood abuse (CA, including neglect and abuse by caregivers before the age of 18 years) have more severe substance dependence problems than those without a history of childhood abuse. However, whether a history of CA exacerbates craving and the mechanism of this effect remain largely unknown. The aim of this study was to explore the role of alexithymia in the effects of CA on craving in a large sample of methamphetamine-dependent individuals based on latent vulnerability theory. A ...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 26, 2024 Category: Psychiatry Authors: Jiajing Chen Dong Mei Wang Yang Tian Rongrong Zhu Yuqing Li Lianglun Jia Fabing Fu Shanshan Tang Xiaotao Wang Li Wang Xiang Yang Zhang Source Type: research

Childhood abuse and craving in methamphetamine-dependent individuals: the mediating role of alexithymia
AbstractIndividuals with a history of childhood abuse (CA,  including neglect and abuse by caregivers before the age of 18 years) have more severe substance dependence problems than those without a history of childhood abuse. However, whether a history of CA exacerbates craving and the mechanism of this effect remain largely unknown. The aim of this study was to explore the role of alexithymia in the effects of CA on craving in a large sample of methamphetamine-dependent individuals based on latent vulnerability theory. A total of 324 methamphetamine-dependent individuals who met DSM-5 criteria for substance use disorder...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 26, 2024 Category: Neuroscience Source Type: research

From pathogenesis of stress-related mental disorders to treatment: beyond the brain
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 22. doi: 10.1007/s00406-024-01791-2. Online ahead of print.NO ABSTRACTPMID:38519738 | DOI:10.1007/s00406-024-01791-2 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 23, 2024 Category: Psychiatry Authors: Xiaoxing Liu Lin Lu Source Type: research

From pathogenesis of stress-related mental disorders to treatment: beyond the brain
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 22, 2024 Category: Neuroscience Source Type: research

Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis
CONCLUSIONS: The close connection between sensorimotor and cognitive impairment as well as the high centrality of sensorimotor symptoms suggests that both domains share aspects of SSD and MOD pathophysiology. But, because the majority of the study population was diagnosed with SSD, the question as to whether sensorimotor symptoms are really a transdiagnostic therapeutic target needs to be examined in future studies including more balanced diagnostic groups.PMID:38509230 | DOI:10.1007/s00406-024-01782-3 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 21, 2024 Category: Psychiatry Authors: Stefan Fritze Geva A Brandt Sebastian Volkmer Jonas Daub Maria Krayem Jacqueline Kukovic Emanuel Schwarz Urs Braun Georg Northoff Robert Christian Wolf Katharina M Kubera Andreas Meyer-Lindenberg Dusan Hirjak Source Type: research

Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis
ConclusionsThe close connection between sensorimotor and cognitive impairment as well as the high centrality of sensorimotor symptoms suggests that both domains share aspects of SSD and MOD pathophysiology. But, because the majority of the study population was diagnosed with SSD, the question as to whether sensorimotor symptoms are really a transdiagnostic therapeutic target needs to be examined in future studies including more balanced diagnostic groups. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 20, 2024 Category: Neuroscience Source Type: research

Evolution of the profiles of new psychotropic drug users before and during the COVID-19 crisis: an original longitudinal approach through multichannel sequence analysis using the French health-care database
This study is one of the first to analyze the profile of psychotropic treatment users during the COVID-19 crisis. Our analysis sheds light on changes in patterns of psychotropic drug use during the COVID-19 pandemic, possibly associated with changes in prescribing conditions and mental health conditions during the crisis. This study also provides an example of the application of an innovative longitudinal analysis methodology in the field of pharmacoepidemiology.PMID:38499795 | DOI:10.1007/s00406-024-01774-3 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 19, 2024 Category: Psychiatry Authors: Marion Istvan M élanie Duval Karl Hodel Aur élie Aquizerate Anicet Chaslerie Pascal Artarit Edouard-Jules Laforgue Caroline Victorri-Vigneau Source Type: research

The impact of aerobic endurance training on cognitive performance in schizophrenic inpatients in a clinical routine setting
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 19. doi: 10.1007/s00406-024-01773-4. Online ahead of print.ABSTRACTThe primary aim of this study was to investigate the impact of aerobic endurance training in schizophrenic inpatients on cognitive performance in a clinical routine setting. Of secondary interest was the influence on psychopathological symptoms. A total of 31 schizophrenic inpatients were randomly assigned to receive either controlled endurance training or occupational therapy. The experimental group underwent endurance training of 20-30 min each, 3 times per week for a total of up to 22 training sessions. The con...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 19, 2024 Category: Psychiatry Authors: Elisa Semler Florian Herpich Leonhard Zellner Sarah Zwick Peter Zwanzger Alexander Brunnauer Source Type: research

Cannabis use, health problems, and criminal offences in Germany: national and state-level trends between 2009 and 2021
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 19. doi: 10.1007/s00406-024-01778-z. Online ahead of print.ABSTRACTThe German federal government plans to decriminalise cannabis. The impact of this policy on use prevalence, cannabis-related health and legal problems cannot be fully anticipated and should be viewed in context with current trends. We used routine data on (a) cannabis use (population-based surveys), (b) cannabis-related diagnoses (ICD-10 code F12) in outpatient medical settings and (c) minor law offences (registered violations against the narcotics law for possessing small amounts) to analyse age and sex-specific ...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 19, 2024 Category: Psychiatry Authors: Jakob Manthey Sinja Klinger Moritz Rosenkranz Larissa Schwarzkopf Source Type: research

Does cannabis use substitute for opioids? A preliminary exploratory survey in opioid maintenance patients
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 19. doi: 10.1007/s00406-023-01718-3. Online ahead of print.ABSTRACTVarious studies showed that people with substance use disorder use cannabis to reduce withdrawal or dose of their main drug. Using a questionnaire about their cannabis use, 118 participants in an opioid maintenance treatment (OMT) in Germany were examined regarding this strategy. 60% reported to use cannabis. Of those, 72% were using cannabis in the suggested way. Cannabis was used to substitute for, e.g., heroin (44.8%) and benzodiazepines (16.4%). We also asked for an estimation of how good cannabis was able to ...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 19, 2024 Category: Psychiatry Authors: Nina Kim Bekier Ulrich Frischknecht Katharina Eidenmueller Franz Grimm Patrick Bach Manuel Stenger Falk Kiefer Derik Hermann Source Type: research