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Genome editing in human cells: Expert group publishes Leopoldina discussion paper
Discussion Paper. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

A novel molecular link between cholesterol, inflammation and liver cancer
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) Hepatocellular carcinoma (HCC) is a deadly disease with no effective cure that develops in the context of liver diseases associated with chronic inflammation. New paper describes how important is the protein c-Fos for HCC development, because it affects cholesterol homeostasis in hepatocytes. Using genetically modified mouse models, researchers at the Spanish National Cancer Research Centre (CNIO) experimentally document how c-Fos modulates premalignant hepatocyte transformation and how this is linked to cholesterol and inflammation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

New research comes to terms with old ideas about canker sores
(University of Gothenburg) A burning pain sensation -- and treatments that do not work. This is what daily life is like for many of those who suffer from recurrent aphthous stomatitis. Research from the Sahlgrenska Academy now sheds new light on the reasons behind this condition found in the mouth. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Asthmatic schoolchildren are 'uncomfortable' using their inhalers
(Queen Mary University of London) Poor asthma control and knowledge are common in children with doctor-diagnosed asthma, according to research by Queen Mary University of London (QMUL). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Scientists discover new category of analgesic drugs that may treat neuropathic pain
This study has also revealed the existence of a platelet alleviating factor (PAF) pain loop, suggesting a possible role for PAF-receptor antagonists. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Penn studies find promise for innovations in liquid biopsies
(University of Pennsylvania School of Medicine) From using fluid in the lungs to better understand the potential of immunotherapy treatments in lung cancer, to tracking circulating tumor cells in prostate cancer, to conducting RNA sequencing of cancer cell clusters from the blood of pancreatic cancer patients, to finding new ways to biopsy tissue from patients who may have esophageal cancer, a series of studies from the Perelman School of Medicine at the University of Pennsylvania demonstrate the promise of new diagnostic methods. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Vaginal estriol gel helps women recover after surgery for pelvic organ prolapse
(The North American Menopause Society (NAMS)) Pelvic organ prolapse is estimated to affect up to one-half of all women, causing pain and interfering with sexual function. A new study demonstrates how an ultralow dose of vaginal estriol gel used before and after pelvic organ prolapse surgery can improve recovery time and results. The study outcomes are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Penn Medicine's Carl June, M.D., named 2017 Fellow of the AACR Academy
(University of Pennsylvania School of Medicine) University of Pennsylvania cancer and HIV gene therapy pioneer Carl June, M.D., has been named as a member of the 2017 class of fellows of the American Association for Cancer Research Academy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

An led-based device for imaging radiation induced skin damage
(The Optical Society) A non-invasive imaging device tested at UC Irvine's Beckman Laser Institute may help predict skin damage effects from radiation treatment in breast cancer patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Scientific discovery opens new possibilities for cancer and fibrosis treatment
(University of Turku) Researchers from the Turku Centre for Biotechnology (BTK) in Finland have discovered that a cellular fuel sensor, known to control energy processes in the cells, is involved in the regulation of the contact of cells with their surrounding environment. This unexpected link could help scientists better understand life-threatening diseases, such as cancer and tissue fibrosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Vaping and withdrawal
(University of Vermont College of Medicine) While the debate regarding the safety of e-cigarettes continues, another issue has emerged: Does vaping cause withdrawal? (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Infant vitamin B1 deficiency leads to poor motor function and balance
(American Friends of Tel Aviv University) A new Tel Aviv University study found that infantile vitamin B1 (thiamine) deficiency severely affected the motor function of preschoolers who were fed faulty formula in the first year of their lives. The conclusions were based on a retrospective study of children who received Remedia, an Israeli formula brand completely lacking in vitamin B1, in 2004. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

NIH designates $42.7 million for food allergy research consortium
(NIH/National Institute of Allergy and Infectious Diseases) The National Institutes of Health intends to award $42.7 million over seven years to the Consortium of Food Allergy Research (CoFAR) so it may continue evaluating new approaches to treat food allergy. Established in 2005, the CoFAR has been continuously funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH. The first year of funding has been awarded, and awards will be made in subsequent years based on the availability of funds. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Vanderbilt study finds natural chemical helps brain adapt to stress
(Vanderbilt University Medical Center) A natural signaling molecule that activates cannabinoid receptors in the brain plays a critical role in stress-resilience -- the ability to adapt to repeated and acute exposures to traumatic stress, according to researchers at Vanderbilt University Medical Center. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Immunologic changes point to potential for clinical investigation of combination immunotherapy for deadly kidney cancer
(University of Texas M. D. Anderson Cancer Center) Immunologic changes observed in an early study of patients with metastatic renal cell carcinoma (MRCC) raised the possibility for a larger clinical study of combination immunotherapy, according to findings reported by researchers at The University of Texas MD Anderson Cancer Center. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Giving brown fat a green light
(Joslin Diabetes Center) Since the discovery in 2009 that brown fat can be active in adult humans, researchers around the world have worked to unveil ways to switch on this fat. Scientists at Joslin Diabetes Center now have identified a new route to throw the switch. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Discovery may help patients beat deadly pneumonia
(University of Virginia Health System) Researchers have identified a hormone that helps fight off a severe form of bacterial pneumonia, and that discovery may offer a simple way to help vulnerable patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Bullies and their victims obsessed with weight-loss
(University of Warwick) School bullies and their victims are more obsessed with weight-loss than anyone else, according to new research by the University of Warwick. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Cost of neurological disease in US Approaching $800 billion a year
(University of South Florida (USF Health)) A new University of South Florida study published in the Annals of Neurology looked at the nine most prevalent and costly diagnosed neurological diseases and found the annual cost to be staggering -- totaling nearly $800 billion. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

'On-off switch' brings researchers a step closer to potential HIV vaccine
(University of Nebraska-Lincoln) University of Nebraska-Lincoln scientists are pursuing an HIV vaccine using a weakened form of HIV. In a recent study, they demonstrated an 'on-off switch' that would shut off replication of the weakened form of HIV after it reached immunity-triggering levels. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Eastern Nursing Research Society honoring Penn nursing's Barbara Medoff-Cooper, PhD
(University of Pennsylvania School of Nursing) Barbara Medoff-Cooper, PhD, RN, FAAN, Professor of Nursing in the Department of Family and Community Health at the University of Pennsylvania School of Nursing (Penn Nursing) and the Ruth M. Colket Professor in Pediatric Nursing at Children's Hospital of Philadelphia, will receive the 2017 Eastern Nursing Research Society's Distinguished Contributions to Nursing Research Award at its annual conference in Philadelphia on April 7, 2017. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

TBI in emergency departments a substantial economic burden
(St. Michael's Hospital) A new study that looked at nearly 134,000 emergency department visits for traumatic brain injury, including concussion, during a one year period in Ontario estimated that those visits had a total cost of $945 million over the lifetimes of those patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Adults with disabilities screened less often for colorectal cancer
(University of Missouri-Columbia) Colorectal cancer is the fourth most common type of cancer in the United States, with nearly 135,000 cases reported in 2016. The likelihood of surviving colorectal cancer is strongly related to the stage in which it is diagnosed. Researchers from the University of Missouri School of Medicine found that individuals with certain disabilities are less likely to receive recommended preventive screenings. The researchers hope the finding will lead to targeted interventions and increased awareness. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

New research explains why even targeted therapies eventually fail in lung cancer
(Cold Spring Harbor Laboratory) New research shows the accumulation of genetic diversity in cancer cells with damaged DNA repair mechanisms contributes to the occurrence of resistance after the exposure of the cells to drugs used to treat tumors. A corollary to this discovery is that killing cancer cells that are more genetically unstable in the earlier stages of tumorigenesis could result in improved outcomes in currently used cancer treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

The IT-LIVER European consortium unveils new TGF-beta functions in liver cancer
(IDIBELL-Bellvitge Biomedical Research Institute) Recent research results from the European consortium IT-Liver provide a better understanding of the role of the TGF-beta cytokine in liver cancer. Their work, published in Cancer Letters, shows how the TGF-beta cytokine is able to modulate not only the migratory capacity of the hepatocellular carcinoma cell but also its capacity as a tumor initiator cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Vulnerability to psychosis: How to detect it
(University of Montreal) An international research team has demonstrated that an exaggerated emotional brain response to non-threatening information predicts emergence of clinically psychotic symptoms. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2017 Category: Global & Universal Source Type: news

Seabird bones, fossils reveal broad food-web shift in North Pacific
(Smithsonian) For thousands of years, the Hawaiian petrel has soared over the Pacific Ocean, feeding on fish and squid. Now, using evidence preserved in the birds' bones, scientists at the Smithsonian's National Museum of Natural History and Michigan State University have discovered that the now endangered seabird has experienced a significant shift in food resources most likely during the past 100 years--a disruption that may be due to industrial fishing practices. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Man with quadriplegia employs injury bridging technologies to move again -- just by thinking
(Case Western Reserve University) A subject who was paralyzed below his shoulders in a bicycling accident, is believed to be the first person with quadriplegia in the world to have arm and hand movements restored with the help of two temporarily implanted technologies.A brain-computer interface with recording electrodes under his skull, and a functional electrical stimulation (FES) system activating his arm and hand, reconnect his brain to paralyzed muscles. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

The Lancet: Neuro-prosthesis reconnects brain to muscles to restore functional arm movements to man with complete paralysis
(The Lancet) A system that decodes brain signals and transmits them to sensors in the arm has allowed a man paralyzed from the shoulders down to regain movement in his hand and arm, according to the first study to report results for this new technology, published in The Lancet. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

New process designed to streamline faster care for EMS triage, transport of stroke patients
(American Heart Association) The new Severity-based Stroke Triage Algorithm for emergency medical services (EMS) equips ambulance crews with information and tools to better identify a stroke, assess a patient's overall condition and determine the best hospital for the patient's specific treatment needs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Neurological diseases cost the US nearly $800 billion per year
(Wiley) A new paper published in the Annals of Neurology reports the most common neurological diseases pose a serious annual financial burden for the nation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Tomographic imaging advances considered good yet can lead to overdiagnosis in PE patients
(American Roentgen Ray Society) Although advances in tomographic imaging have improved the sensitivity of ventilation-perfusion (V/Q) scans for pulmonary embolism (PE), they may lead to overdiagnosis by revealing small and clinically insignificant PEs, according to a state-of-the-art review published in the March 2017 issue of the American Journal of Roentgenology (AJR). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

New report lays plan to eliminate 90,000 hepatitis B and C deaths by 2030
(National Academies of Sciences, Engineering, and Medicine) Hepatitis B and C kill more than 20,000 people every year in the United States. A new report from the National Academies of Sciences, Engineering, and Medicine presents a strategy to eliminate these diseases as serious public health problems and prevent nearly 90,000 deaths by 2030. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Abuse accelerates puberty in children
(Penn State) While it has long been known that maltreatment can affect a child's psychological development, new Penn State research indicates that the stress of abuse can impact the physical growth and maturation of adolescents as well. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Brain stimulation improves schizophrenia-like cognitive problems
(University of Iowa Health Care) A new study from the University of Iowa Carver College of Medicine finds that stimulating the cerebellum in rats with schizophrenia-like thinking problems normalizes brain activity in the frontal cortex and corrects the rats' ability to estimate the passage of time -- a cognitive deficit that is characteristic in people with schizophrenia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

A molecular on/off switch for CRISPR
(Scripps Research Institute) TSRI scientists reveal how viruses disable bacterial immune systems. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

$1 million grant to Yijun Ruan of JAX from Human Frontier Science Program
(Jackson Laboratory) Jackson Laboratory Professor Yijun Ruan, Ph.D., a leader in the study of the three-dimensional organization of the human genome, has received a three-year grant totaling $1,050,000 from the international Human Frontier Science Program to explore the fundamental mechanics involved in memory and learning as well as epilepsy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Can intergenerational cooperation defeat climate change?
(The Gerontological Society of America) Older adults are powerful allies in addressing climate change, according to 'Gray and Green Together: Climate Change in an Aging World,' the latest edition of Public Policy& Aging Report (PP&AR) from The Gerontological Society of America (GSA). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Broad support exists for larger warnings on cigarette packs
(UNC Lineberger Comprehensive Cancer Center) A UNC Lineberger Comprehensive Cancer Center study found broad support, even among smokers, for increasing the size of health warnings on cigarette packs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Study finds that elevating women's status lowers dependence on solid fuels
(Lehigh University) A new research paper finds that in countries where gender inequalities are most pronounced, women are much more likely to be exposed to solid fuel -- including burning from wood, crop wastes, charcoal, and dung -- and its negative consequences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Elevated blood pressure not a high mortality risk for elderly with weak grip
(Oregon State University) A study of nearly 7,500 Americans age 65 or older suggests that elevated blood pressure is not related to high mortality risk among people in that age group with weak grip strength. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Alcohol use in veterans with schizophrenia less common than thought; no level safe
(University of California - Los Angeles) US veterans who are being treated for schizophrenia are much less likely to drink any alcohol than the general population. But when they do misuse alcohol, it leads to worsening of their symptoms. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

TSRI researchers develop new method to 'fingerprint' HIV
(Scripps Research Institute) Scientists at The Scripps Research Institute (TSRI) have developed a method to analyze the glycan shield on HIV's protective outer glycoprotein, developed as a potential HIV vaccine candidate. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Rarely studied gene USF3 plays role in predisposition to thyroid cancer
(Cleveland Clinic) Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

ACP decries devastating impact of climate change order
(American College of Physicians) President Trump's executive order on climate change will have a devastating impact on public health, said the American College of Physicians (ACP) today. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Stop eating! You are full
(PLOS) A novel role as appetite suppressant for BH4, a well-known enzyme cofactor. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

UTHealth researchers collaborate to increase low vaccination rates in Houston schools
(University of Texas Health Science Center at Houston) Susan Wootton, M.D., associate professor of pediatric infectious diseases at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), will lead a project to increase low vaccination rates among pre-kindergarten and kindergarten students in the Houston Independent School District (HISD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Key research priorities for agricultural microbiomes identified
(PLOS) A coordinated effort to understand plant microbiomes could boost plant health and agricultural productivity, according to a new Perspective publishing March 28 in the open access journal PLOS Biology by Posy Busby of Oregon State University in Corvallis and colleagues at eight other research institutions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

Novel approach can reveal personalized breast cancer treatments
(Baylor College of Medicine) Researchers from various institutions, including Baylor College of Medicine, have developed a new way to approach breast cancer treatment. First, they search for the proteins that drive tumor growth, and then test in the lab drugs that potentially neutralize these specific biological drivers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news

When writing interferes with hearing
(Universit é de Gen è ve) A cochlear implant is an electronic device capable of restoring hearing in a profoundly deaf person by stimulating the nerve endings in the inner ear. However, results can be extremely variable. Using brain imaging techniques, a neuroscientist from University of Geneva and a Parisian ENT surgeon have managed to predict the success of a cochlear implant among people who became profoundly deaf in their adult life. This research may be found in Nature Communications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2017 Category: Global & Universal Source Type: news