Study reveals new therapeutic target for C. difficile infection
(University of California - Irvine) A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 18, 2021 Category: Infectious Diseases Source Type: news

Undiagnosed and untreated disease identified in rural South Africa
(University of Alabama at Birmingham) A comprehensive health-screening program in rural northern KwaZulu-Natal, South Africa, has found a high burden of undiagnosed or poorly controlled non-communicable diseases, according to a study published in The Lancet Global Health. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 18, 2021 Category: Infectious Diseases Source Type: news

Start-stop system of hunting immune cells
(Max Planck Institute of Immunobiology and Epigenetics) Researchers from the MPI of Immunobiology and Epigenetics decipher the basic biology of neutrophil swarming and now show that the cells also evolved an intrinsic molecular program to self-limit their swarming activity. The study elucidates how swarming neutrophils become insensitive to their own secreted signals that brought the swarm together in the first place. This process is crucial for the efficient elimination of bacteria in tissues. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Yellow fever mosquitoes evolve different strategies to resist pesticides
(PLOS) The yellow fever mosquito (scientific name, Aedes aegypti) spreads multiple untreatable viruses in humans and is primarily controlled using a pesticide called permethrin. However, many mosquitoes are evolving resistance to the pesticide. A new study by Karla Saavedra-Rodriguez of Colorado State University and colleagues, published in the journal PLOS Genetics, identifies mutations linked to different permethrin resistance strategies, which threaten our ability to control disease outbreaks. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Targeting cellular response to SARS-CoV-2 holds promise as new way to fight infection
(University of Cambridge) A new treatment approach focused on fixing cell damage, rather than fighting the virus directly, is effective against SARS-CoV-2 in lab models. Combination of two drugs reduces spread of SARS-CoV-2 infection in cells by up to 99.5%.If found safe for human use, this anti-viral treatment would make COVID-19 symptoms milder and speed up recovery times. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Study validates a highly sensitive molecular test to detect cases of Tubercul
(Barcelona Institute for Global Health (ISGlobal)) The 'Xpert Ultra' molecular test has a greater capacity than its predecessor ('Xpert MTB/RIF') in detecting tuberculosis cases, either passively (i.e. people who attend the hospital with disease symptoms) or actively (searching for possible cases in the community among contacts of cases). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Covid-19 vaccine efficacy study named AJPM's most influential paper of 2020
(CUNY Graduate School of Public Health and Health Policy) Last summer, researchers from PHICOR at CUNY SPH developed a computational model of the US population that simulated the spread and impact of Covid-19. The model served as a virtual laboratory to test the effect of Covid-19 vaccines with a variety of efficacies, administered in different ways and times to different proportions of the population. This work was deemed paper of the year in 2020 by the American Journal of Preventive Medicine on June 17, 2020. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

New in the Hastings Center Report, May-June 2021
(The Hastings Center) New in the Hastings Center Report: Racial justice and environmental toxins, gene editing, Covid, and more in the May-June 2021 issue. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

'Nanodecoy' therapy binds and neutralizes SARS-CoV-2 virus
(North Carolina State University) Nanodecoys made from human lung spheroid cells (LSCs) can bind to and neutralize SARS-CoV-2, promoting viral clearance and reducing lung injury in a macaque model of COVID-19. By mimicking the receptor that the virus binds to rather than targeting the virus itself, nanodecoy therapy could remain effective against emerging variants of the virus. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Trojan horses & tunneling nanotubes: Ebola research at Texas Biomed gets NIH funding boost
(Texas Biomedical Research Institute) Scientists have a general idea of how viruses invade and spread in the body, but the precise mechanisms are actually not well understood, especially when it comes to Ebola virus. Olena Shtanko, Ph.D., a Staff Scientist at the Texas Biomedical Research Institute (Texas Biomed), has received more than $1 million from the National Institutes of Health (NIH) to explore different aspects of Ebola virus infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Incidents of serious parasitic disease on the rise in Alberta, Canada
(University of Alberta Faculty of Medicine& Dentistry) A rare parasitic infection imported from Europe continues to take root in Alberta. The province is now the North American hotspot for human alveolar echinococcosis (AE), which takes the form of a growth in the liver, causing serious and potentially deadly health complications. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Vaccination, previous infection, protect against gamma variant in animal model
(University of Wisconsin-Madison) In a new study using variant virus recovered from one of the original travelers, researchers in the US and Japan have found that vaccination with an mRNA vaccine induces antibody responses that would protect humans from infection with the gamma/P.1 variant. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

New study finds SARS-CoV-2 can infect testes
(University of Texas Medical Branch at Galveston) Researchers at the University of Texas Medical Branch have found SARS-CoV-2 in the testes of infected hamsters. The authors think this may represent what could occur in men with mild to moderate COVID-19 disease. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Disadvantaged neighborhoods see more COVID-19 infections and deaths
(The Mount Sinai Hospital / Mount Sinai School of Medicine) New York City neighborhoods that had higher levels of socioeconomic disadvantage experienced more COVID-19 infections and deaths, according to Mount Sinai scientists who created a neighborhood-level COVID-19 inequity index. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 17, 2021 Category: Infectious Diseases Source Type: news

Community pharmacy can play a 'key clinical role' in delivery of COVID-19 vaccinations
(Aston University) New research published in BMJ Open shows that community pharmacy could play a 'key clinical role' in the future of COVID-19 vaccination programmes, according to a study led by Aston University in Birmingham, UK, in collaboration with UK and international researchers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 16, 2021 Category: Infectious Diseases Source Type: news