Pax6 isoforms shape eye development: Insights from developmental stages and organoid models
In this study, we investigated the spatial and temporal expression patterns of Pax6 isoforms during different stages of mouse eye development. We observed a strong correlation between Pax6a expression and the neuroretina gene Sox2, while Pax6b showed a high correlation with iris-component genes, including the mesenchymal gene Foxc1. During early patterning from E10.5, Pax6b was expressed in the hinge of the optic cup and neighboring mesenchymal cells, whereas Pax6a was absent in these regions. At E14.5, both Pax6a and Pax6b were expressed in the future iris and ciliary body, coinciding with the integration of mesenchymal c...
Source: Differentiation - April 17, 2024 Category: Research Authors: Shih-Shun Hung Po-Sung Tsai Ching-Wen Po Pei-Shan Hou Source Type: research
Fibroblast Growth Factor 6
Differentiation. 2024 Apr 10;137:100780. doi: 10.1016/j.diff.2024.100780. Online ahead of print.ABSTRACTFibroblast Growth Factor 6 (FGF6), also referred to as HST2 or HBGF6, is a member of the Fibroblast Growth Factor (FGF), the Heparin Binding Growth Factor (HBGF) and the Heparin Binding Secretory Transforming Gene (HST) families. The genomic and protein structure of FGF6 is highly conserved among varied species, as is its expression in muscle and muscle progenitor cells. Like other members of the FGF family, FGF6 regulates cell proliferation, differentiation, and migration. Specifically, it plays key roles in myogenesis ...
Source: Differentiation - April 16, 2024 Category: Research Authors: Jennelle Smith Loydie A Jerome-Majewska Source Type: research
Fibroblast Growth Factor 6
Differentiation. 2024 Apr 10;137:100780. doi: 10.1016/j.diff.2024.100780. Online ahead of print.ABSTRACTFibroblast Growth Factor 6 (FGF6), also referred to as HST2 or HBGF6, is a member of the Fibroblast Growth Factor (FGF), the Heparin Binding Growth Factor (HBGF) and the Heparin Binding Secretory Transforming Gene (HST) families. The genomic and protein structure of FGF6 is highly conserved among varied species, as is its expression in muscle and muscle progenitor cells. Like other members of the FGF family, FGF6 regulates cell proliferation, differentiation, and migration. Specifically, it plays key roles in myogenesis ...
Source: Differentiation - April 16, 2024 Category: Research Authors: Jennelle Smith Loydie A Jerome-Majewska Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
Differentiation. 2024 Mar 11;137:100765. doi: 10.1016/j.diff.2024.100765. Online ahead of print.ABSTRACTThe acquisition of the post-mitotic state is crucial for the execution of many terminally differentiated cell behaviors during organismal development. However, the mechanisms that maintain the post-mitotic state in this context remain poorly understood. To gain insight into these mechanisms, we used the genetically and visually accessible model of C. elegans anchor cell (AC) invasion into the vulval epithelium. The AC is a terminally differentiated uterine cell that normally exits the cell cycle and enters a post-mitotic...
Source: Differentiation - March 24, 2024 Category: Research Authors: Michael A Q Martinez Chris Z Zhao Frances E Q Moore Callista Yee Wan Zhang Kang Shen Benjamin L Martin David Q Matus Source Type: research
