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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 27, 2024 Category: Pathology Source Type: research

How to distinguish between reactive and neoplastic flat urothelial lesions
We describe the most frequent entities with a focus on clinical meaning. Several of these described lesions do not figure in the WHO 2022 classification; t herefore knowledge of them is important. We also discuss benign, precursor and malignant lesions and suggest the latest nomenclatures given by international societies. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 27, 2024 Category: Pathology Authors: Eva Comp érat, Johannes Kläger, André Oszwald, Shahrokh Shariat, Gabriel Wasinger Tags: Mini-symposium: urological pathology Source Type: research

Determining the diagnosis of an oncocytic renal neoplasm: a case report
This is the case of a 45 year old male patient with an oncocytic renal neoplasm that was difficult to classify. Histology from a partial nephrectomy revealed a tumour comprising oncocytic cells containing rounded nuclei with some prominent nucleoli, although no necrosis or lymphovascular invasion. CK7 immunohistochemistry was focally positive, with only weak staining for CD117. There are multiple lesions to consider in the differential diagnosis of oncocytic renal tumours with borderline features between oncocytoma and chromophobe carcinoma. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 27, 2024 Category: Pathology Authors: Clare McGenity, Simon Vlies, Jo-An Roulson Tags: Short case Source Type: research

Best practices and recommendations for grossing and reporting of post-immunotherapy nephrectomy specimens: a single-institution experience of 70 cases
The gross handling of and reporting of renal cell carcinoma in the setting of neoadjuvant immune checkpoint inhibitor therapy presents unique challenges, and there is little known about the spectrum of histologic changes that can be seen in this setting. We studied 70 cases of RCC, status post immunotherapy and nephrectomy at our institute and devised a standardized grossing protocol to help assess pathologic response. Our protocol includes sampling a complete cross section of the largest diameter of tumor with additional sections from areas of gross extrarenal involvement. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 26, 2024 Category: Pathology Authors: Michael J Hwang, Patrick M Brennan, Bryan M Monge, Bassam Alkamachi, Prih Rohra, Mekenzie M Peshoff, Padmanee Sharma, Kanishka Sircar, Pheroze Tamboli, Priya Rao Tags: Mini-symposium: urological pathology Source Type: research

Testicular germ cell tumors: challenges in tumor diagnosis and pathological staging
Testis tumors are the most common malignancies in young men. The most common testis tumors are germ cell tumors (GCT) that are considered curable diseases due to excellent prognosis. Management of GCT begins with radical orchiectomy. Once the specimen arrives on pathologist's bench, accurate diagnosis begins with obtaining proper clinical history, careful macroscopic examination, and proper sampling. Finally, the information provided by pathologist outlines the need for further treatment, clinical behavior, and outcome of tumor. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 26, 2024 Category: Pathology Authors: Ali Amin, Liang Cheng Tags: Short case Source Type: research

Molecular uropathology: what a practising pathologist should know
Advancements in molecular pathology have initiated a transformative era in the diagnostic classification and treatment of urological cancers. The 2022 WHO classification exemplifies this evolution by introducing molecularly defined renal cell carcinoma entities. The synthesis of clinical, pathological, and molecular findings leveraging large-scale technologies like next-generation sequencing (NGS) has led to a significant acceleration of precision oncology. Predictive biomarker testing has gained significant importance in urological malignancies, especially in urothelial cancer and prostate cancer underscored by novel targ...
Source: Diagnostic Histopathology - February 21, 2024 Category: Pathology Authors: Veronika Bahlinger, Fabienne Lange, Markus Eckstein Tags: Mini-symposium: urological pathology Source Type: research

Microscopic colitis: what's in a name? An overview from clinical and histological perspectives
Microscopic colitis presents as chronic watery diarrhoea and leads to a significant disease burden. Specific histological characteristics are key to diagnosing microscopic colitis and to specify its subtypes collagenous colitis or lymphocytic colitis. Histological hallmarks of microscopic colitis are an increased inflammatory infiltrate in the lamina  propria without significant crypt architectural distortion and intraepithelial lymphocytosis, which is generally more prominent in lymphocytic colitis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 10, 2024 Category: Pathology Authors: Chella S van der Post, Danny Goudkade, Bas PM Verhaegh Tags: Mini-symposium: gastrointestinal and hepato-pancreato-biliary pathology Source Type: research

Vascular pathology of the gastrointestinal tract
Vascular pathology of the GI tract is prevalent worldwide. The etiologies associated with the histologic findings of “ischemic type injury” include common entities (such as atherosclerosis) as well as rare disease. This review article aims to describe the histologic findings of common and uncommon diseases resulting in vascular pathology, to help pathologists improve their diagnostic accuracy and guide clinici ans in the management of these patients. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 9, 2024 Category: Pathology Authors: Saleh Fadel, Daniela S. Allende Tags: Mini-symposium: Gastrointestinal and hepato-pancreato-biliary pathology Source Type: research

Preinvasive neoplasia of the gallbladder: flat and tumoral dysplasia
Gallbladders are one of the most commonly encountered specimens in routine histopathology. While the usual diagnoses of cholelithiasis and cholecystitis are relatively straightforward, the evaluation of neoplastic changes in the gallbladder can be challenging. Non-invasive neoplasia in the gallbladder can be broadly categorised into flat or non-tumoral dysplasia and tumoral dysplasia, the latter mainly incorporating intracholecystic papillary neoplasms, akin to lesions seen within the bile ducts and pancreas. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 7, 2024 Category: Pathology Authors: Gavin Baker, Paul Kelly Tags: Mini-symposium: gastrointestinal and hepato-pancreato-biliary pathology Source Type: research

Histopathological risk stratification of pT1 colorectal cancer: novel insights into established risk factors
The proportion of submucosal invasive (pT1) colorectal cancer (CRC) diagnoses has increased substantially since the introduction of CRC screening programmes. A distinct attribute of pT1 CRCs is that they can be potentially cured through local excision. With advancements in endoscopic or minimally invasive surgical resection techniques, local excision has become the primary treatment modality for the majority of these malignant polyps. After local excision, the decision regarding the need for additional surgical intervention is primarily based on the presence of histopathological risk factors for lymph node metastasis (LNM)...
Source: Diagnostic Histopathology - February 6, 2024 Category: Pathology Authors: Lisa van der Schee, Miangela M. Lacl é Tags: Mini-symposium: gastrointestinal and hepato-pancreato-biliary pathology Source Type: research

Colonisation or invasion: a diagnostic dilemma in a ‘benign’ gallbladder
We describe the case of a 60-year-old man who underwent an elective cholecystectomy for recurrent biliary colic. On microscopic examination, an incidental intracholecystic papillary neoplasm was present at the cystic duct margin, and was also found to colonise Rokitansky-Aschoff sinuses. We discuss this diagnostic pitfall for invasion and the diagnostic and management implications for this rare lesion. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 5, 2024 Category: Pathology Authors: Daniel T. Field, Alan Stockman, Timothy J. Kendall Tags: Short case Source Type: research

The morphomolecular features of cholangiocarcinoma in the personalised era
Cholangiocarcinoma is a group of diverse invasive malignancies arising along the biliary tract. The outcomes for patients with cholangiocarcinoma remain poor but an understanding of molecular aberrations and subsequent targeted therapies to these have opened up new treatment prospects. This review describes the clinical and morphological features and classifications of intrahepatic and perihilar cholangiocarcinoma in addition to laying out the related landscape of the molecular pathology within cholangiocarcinoma. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 4, 2024 Category: Pathology Authors: Daniel T. Field, Guido Carpino, Michail Doukas, Timothy J. Kendall Tags: Mini-symposium: Gastrointestinal and hepato-pancreato-biliary pathology Source Type: research

Pitfalls and mass-forming mimics of pancreatic cancer
The diagnostic pathway of pancreatic lesions has changed since endoscopic ultrasound-guided biopsies were introduced. The tissue diagnosis of pancreatic ductal adenocarcinoma (PDAC) used to be made by cytology or surgical specimens, while pancreatic biopsies currently contribute to a pretreatment diagnosis in>80  % of cases. Pathologists need to assess subtle changes in biopsy specimens, in order to avoid over- and under-diagnosis of PDAC. The lack of stromal reaction does not exclude the possibility of PDAC, while abnormal distribution of the ducts and a mild but sufficient degree of nuclear atypia are di agnostic clues ...
Source: Diagnostic Histopathology - February 1, 2024 Category: Pathology Authors: Yoh Zen Tags: Mini-symposium: gastrointestinal and hepato-pancreato-biliary pathology Source Type: research

Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - January 31, 2024 Category: Pathology Source Type: research