Diabetes/Metabolism Research and Reviews This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Abscisic acid stimulates the release of insulin and of GLP ‐1 in the rat perfused pancreas and intestine
ConclusionOur results indicate the existence of a cross talk between GLP ‐1 and ABA, whereby ABA stimulates GLP‐1 secretion, and viceversa. Release of ABA could be considered as a new promising molecule in the strategy of T2D treatment and as a new endogenous hormone in the regulation of glycaemia. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 23, 2018 Category: Endocrinology Authors: Valeria Booz, Charlotte Bayer Christiansen, Rune Ehrenreich Kuhre, Monika Yosifova Saltiel, Giovanna Sociali, Nicola Schaltenberg, Alexander W. Fischer, J örg Heeren, Elena Zocchi, Jens J. Holst, Santina Bruzzone Tags: RESEARCH ARTICLE Source Type: research

Differences between the international guideline and national guidelines for the management of diabetic foot disease
ConclusionsNational diabetic foot disease guidelines from a large and diverse region of the world showed limited similarity to recommendations made in the peak international guidelines. The differences between the recommendations may contribute to differences in national diabetic foot disease outcomes and burdens. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 23, 2018 Category: Endocrinology Authors: C.N. Parker, J.J. Van Netten, T.J. Parker, L. Jia, H. Corcoran, M. Garrett, C.F. Kwok, A. Nather, M.T. Que, G. Srisawasdi, P. Wraight, P.A. Lazzarini Tags: RESEARCH ARTICLE Source Type: research

Diabetes pharmacotherapy and effects on the musculoskeletal system
AbstractPersons with type 1 or type 2 diabetes (T1D, T2D) have a significantly higher fracture risk than age ‐matched persons without diabetes, attributed to disease‐specific deficits in the microarchitecture and material properties of bone tissue. Therefore, independent effects of diabetes drugs on skeletal integrity are vitally important. Studies of incretin‐based therapies have shown divergent eff ects of different agents on fracture risk, including detrimental, beneficial and neutral effects. The sulfonylurea class of drugs, owing to its hypoglycemic potential, is thought to amplify the risk of fall‐related fra...
Source: Diabetes/Metabolism Research and Reviews - November 22, 2018 Category: Endocrinology Authors: Evangelia Kalaitzoglou, John L. Fowlkes, Iuliana Popescu, Kathryn M. Thrailkill Tags: REVIEW ARTICLE Source Type: research

The LepRdb/db mice model for studying glycation in the context of diabetes.
ConclusionsThedb/db model better reflected the characteristics of human T2D compared with the DIO models, and exhibited greater formation and accumulation of both furosine and protein ‐bound CML in all of the organs tested here. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 22, 2018 Category: Endocrinology Authors: Axel Guilbaud, Michael Howsam, Celine Niquet ‐Léridon, Florian Delguste, Eric Boulanger, Frédéric J. Tessier Tags: RESEARCH ARTICLE Source Type: research

MicroRNA ‐296‐5p promotes healing of diabetic wound by targeting sodium‐glucose transporter 2 (SGLT2)
ConclusionsmiR ‐296‐5p can increase the healing rate of diabetic wounds and may be an effective molecular tool in DM diagnosis and therapy. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 22, 2018 Category: Endocrinology Authors: Xiaomin Liu, Yanmao Wang, Xiaotian Zhang, Xinju Zhang, Jing Guo, Jinbao Zhou, Yimin Chai, Zhong ‐liang Ma Tags: RESEARCH ARTICLE Source Type: research

Aerobic exercise training may improve nerve function in type 2 diabetes and pre ‐diabetes: a systematic review
ConclusionsEvidence from this systematic review suggests aerobic exercise training may positively influence nerve function among people with type 2 diabetes mellitus, with minimal risk of adverse events. Further research will be required to determine the optimal dosage of exercise training and the effect on nerve function in pre ‐diabetes and in women with previous gestational diabetes. This review is registered on PROSPERO (CRD42018088182). (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 21, 2018 Category: Endocrinology Authors: Yu Gu, Sarah M. Dennis, Matthew C. Kiernan, Alison R. Harmer Tags: REVIEW ARTICLE Source Type: research

The peripheral atherosclerotic profile in patients with type 1 diabetes warrants a thorough vascular assessment of asymptomatic patients
ConclusionsPeripheral artery disease is often undiagnosed in asymptomatic patients with DM1. However, its presence may change medical management in a substantial percentage of cases, highlighting the potential benefit of a thorough vascular assessment on these patients. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 20, 2018 Category: Endocrinology Authors: L ía Nattero‐Chávez, Sandra Redondo López, Sara Alonso Díaz, Marta Garnica Ureña, Elena Fernández‐Durán, Héctor F. Escobar‐Morreale, Manuel Luque‐Ramírez Tags: RESEARCH ARTICLE Source Type: research

Resistin is a prognostic factor in type 2 diabetes.
ConclusionsHigher resistin is associated with reduced survival in T2D, irrespectively of TNF ‐α. Resistin concentration of above 11 ng/mL indicates T2D patients at an increased risk of unfavorable outcomes. Leptin was not a prognostic factor. These results suggest that in T2D, association of resistin with unfavorable outcomes might, at least in part, result from its pro‐inflammatory pr operties. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 16, 2018 Category: Endocrinology Authors: Agnieszka Kap łon‐Cieślicka, Agata Tymińska, Marek Rosiak, Krzysztof Ozierański, Michał Peller, Ceren Eyileten, Agnieszka Kondracka, Justyna Pordzik, Dagmara Mirowska‐Guzel, Grzegorz Opolski, Marek Postuła, Krzysztof J. Filipiak Tags: RESEARCH ARTICLE Source Type: research

Understanding the growing epidemic of type 2 diabetes in the hispanic population living in the united states
AbstractThe prevalence and incidence of type 2 diabetes (T2D) among the Hispanic population in the United States is higher than the national average. This is partly due to sociocultural factors, such as lower income and decreased access to education and health care, as well as a genetic susceptibility to obesity and higher insulin resistance.This review focuses on understanding the Hispanic population living in the US from a multidisciplinary approach and underlines the importance of cultural, social and biological factors in determining the increased risk of T2D in this population. An overview of the acute and chronic com...
Source: Diabetes/Metabolism Research and Reviews - November 16, 2018 Category: Endocrinology Authors: Cristina Aguayo ‐Mazzucato, Paula Diaque, Sonia Hernandez, Silvia Rosas, Aleksandar Kostic, A. Enrique Caballero Tags: REVIEW ARTICLE Source Type: research

Galectin ‐3 and risk of cardiovascular events and all‐cause mortality in type 2 diabetes
ConclusionsSerum galectin ‐3 is associated with adverse cardiovascular outcomes in persons with type 2 diabetes independent of traditional risk factors. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 15, 2018 Category: Endocrinology Authors: Kathryn C.B. Tan, Ching ‐Lung Cheung, Alan C.H. Lee, Joanne K.Y. Lam, Ying Wong, Sammy W.M. Shiu Tags: RESEARCH ARTICLE Source Type: research

Continuous glucose monitoring defined glucose variability is associated with cardiovascular autonomic neuropathy in type 1 diabetes
ConclusionsCGM ‐defined GV was associated with CAN independent of mean glucose in adults with type 1 diabetes. Among internationally standardized CGM parameters, those describing the degree of level 2 hypoglycaemia were the most significant contributors to this association. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 12, 2018 Category: Endocrinology Authors: Ji Eun Jun, Seung ‐Eun Lee, You‐Bin Lee, Ji Yeon Ahn, Gyuri Kim, Kyu Yeon Hur, Moon‐Kyu Lee, Sang‐Man Jin, Jae Hyeon Kim Tags: RESEARCH ARTICLE Source Type: research

Physiological factors influencing diabetes control in type 1 diabetes children with insulin pumps from diagnosis
ConclusionsThis study shows that for those who initiated CSII at T1D onset, younger age, less intense autoimmune process, a low HbA1c at recognition, and good diabetes control during the first year of treatment were associated with long ‐term optimal glycaemic control. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 8, 2018 Category: Endocrinology Authors: Katarzyna Piechowiak, Agnieszka Szypowska Tags: RESEARCH ARTICLE Source Type: research

Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein ‐2
ConclusionsMetformin attenuates diabetes ‐induced renal medullary tissue hypoxia in an animal model of insulinopenic type 1 diabetes. The results suggest that the mechanistic pathway to attenuate the diabetes‐induced medullary hypoxia is independent of blood glucose homeostasis and includes reduced UCP2‐mediated mitochondrial proton LEAK. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 8, 2018 Category: Endocrinology Authors: Michael Christensen, Tomas A. Schiffer, H åkan Gustafsson, Søren Palmelund Krag, Rikke Nørregaard, Fredrik Palm Tags: RESEARCH ARTICLE Source Type: research

Cognitive impairment and postural control deficit in adults with Type 2 diabetes
AbstractBackgroundDiseases induced by metabolic disorders, eg, Type 2 diabetes, has recently been linked to both sensory and motor deficit in the absence of a formal clinical diagnosis of peripheral neuropathy. Studies have demonstrated mild cognitive impairment in diabetic patients, which also plays a role in one's loss of ability to successfully perform basic motor activities. This project focused on evaluating cognitive function while maintaining balance. We hypothesized that simultaneous cognitive and motor deficit would occur among adults with Type 2 diabetes versus healthy age ‐ and sex‐matched control during a b...
Source: Diabetes/Metabolism Research and Reviews - November 8, 2018 Category: Endocrinology Authors: Stacey L. Gorniak, Fangmei Yoshimi Lu, Beom Chan Lee, Paul J. Massman, Jing Wang Tags: RESEARCH ARTICLE Source Type: research

Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance
ConclusionsThese data demonstrate that increased AT expression of CCL19 in obesity may represent a molecular link between metabolic inflammation and insulin resistance. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 8, 2018 Category: Endocrinology Authors: Shihab Kochumon, Fatema Al ‐Rashed, Mohamed Abu‐Farha, Sriraman Devarajan, Jaakko Tuomilehto, Rasheed Ahmad Tags: RESEARCH ARTICLE Source Type: research