Dyrk1a is required for craniofacial development in Xenopus laevis
This study is the first to provide insight into why craniofacial birth defects might arise in humans with variants of DYRK1A.PMID:38621649 | DOI:10.1016/j.ydbio.2024.04.004 (Source: Developmental Biology)
Source: Developmental Biology - April 15, 2024 Category: Biology Authors: H Katherine Johnson Stacey E Wahl Fatmata Sesay Larisa Litovchick Amanda Jg Dickinson Source Type: research
Dyrk1a is required for craniofacial development in Xenopus laevis
This study is the first to provide insight into why craniofacial birth defects might arise in humans with variants of DYRK1A.PMID:38621649 | DOI:10.1016/j.ydbio.2024.04.004 (Source: Developmental Biology)
Source: Developmental Biology - April 15, 2024 Category: Biology Authors: H Katherine Johnson Stacey E Wahl Fatmata Sesay Larisa Litovchick Amanda Jg Dickinson Source Type: research
A new atlas to study embryonic cell types in Xenopus
Dev Biol. 2024 Apr 11:S0012-1606(24)00098-8. doi: 10.1016/j.ydbio.2024.04.003. Online ahead of print.ABSTRACTThis paper introduces a single-cell atlas for pivotal developmental stages in Xenopus, encompassing gastrulation, neurulation, and early tailbud. Notably surpassing its predecessors, the new atlas enhances gene mapping, read counts, and gene/cell type nomenclature. Leveraging the latest Xenopus tropicalis genome version, alongside advanced alignment pipelines and machine learning for cell type assignment, this release maintains consistency with previous cell type annotations while rectifying nomenclature issues. Emp...
Source: Developmental Biology - April 13, 2024 Category: Biology Authors: Kseniya Petrova Maksym Tretiakov Aleksandr Kotov Anne H Monsoro-Burq Leonid Peshkin Source Type: research
TATA-binding associated factors have distinct roles during early mammalian development
Dev Biol. 2024 Apr 7;511:53-62. doi: 10.1016/j.ydbio.2024.04.002. Online ahead of print.ABSTRACTEarly embryonic development is a finely orchestrated process that requires precise regulation of gene expression coordinated with morphogenetic events. TATA-box binding protein-associated factors (TAFs), integral components of transcription initiation coactivators like TFIID and SAGA, play a crucial role in this intricate process. Here we show that disruptions in TAF5, TAF12 and TAF13 individually lead to embryonic lethality in the mouse, resulting in overlapping yet distinct phenotypes. Taf5 and Taf12 mutant embryos exhibited a...
Source: Developmental Biology - April 9, 2024 Category: Biology Authors: Xinjian Doris He Shelby Phillips Kaito Hioki Prabin Dhangada Majhi Courtney Babbitt Kimberly D Tremblay Leonid A Pobezinsky Jesse Mager Source Type: research
TATA-binding associated factors have distinct roles during early mammalian development
Dev Biol. 2024 Apr 7;511:53-62. doi: 10.1016/j.ydbio.2024.04.002. Online ahead of print.ABSTRACTEarly embryonic development is a finely orchestrated process that requires precise regulation of gene expression coordinated with morphogenetic events. TATA-box binding protein-associated factors (TAFs), integral components of transcription initiation coactivators like TFIID and SAGA, play a crucial role in this intricate process. Here we show that disruptions in TAF5, TAF12 and TAF13 individually lead to embryonic lethality in the mouse, resulting in overlapping yet distinct phenotypes. Taf5 and Taf12 mutant embryos exhibited a...
Source: Developmental Biology - April 9, 2024 Category: Biology Authors: Xinjian Doris He Shelby Phillips Kaito Hioki Prabin Dhangada Majhi Courtney Babbitt Kimberly D Tremblay Leonid A Pobezinsky Jesse Mager Source Type: research
TATA-binding associated factors have distinct roles during early mammalian development
Dev Biol. 2024 Apr 7;511:53-62. doi: 10.1016/j.ydbio.2024.04.002. Online ahead of print.ABSTRACTEarly embryonic development is a finely orchestrated process that requires precise regulation of gene expression coordinated with morphogenetic events. TATA-box binding protein-associated factors (TAFs), integral components of transcription initiation coactivators like TFIID and SAGA, play a crucial role in this intricate process. Here we show that disruptions in TAF5, TAF12 and TAF13 individually lead to embryonic lethality in the mouse, resulting in overlapping yet distinct phenotypes. Taf5 and Taf12 mutant embryos exhibited a...
Source: Developmental Biology - April 9, 2024 Category: Biology Authors: Xinjian Doris He Shelby Phillips Kaito Hioki Prabin Dhangada Majhi Courtney Babbitt Kimberly D Tremblay Leonid A Pobezinsky Jesse Mager Source Type: research
TATA-binding associated factors have distinct roles during early mammalian development
Dev Biol. 2024 Apr 7:S0012-1606(24)00091-5. doi: 10.1016/j.ydbio.2024.04.002. Online ahead of print.ABSTRACTEarly embryonic development is a finely orchestrated process that requires precise regulation of gene expression coordinated with morphogenetic events. TATA-box binding protein-associated factors (TAFs), integral components of transcription initiation coactivators like TFIID and SAGA, play a crucial role in this intricate process. Here we show that disruptions in TAF5, TAF12 and TAF13 individually lead to embryonic lethality in the mouse, resulting in overlapping yet distinct phenotypes. Taf5 and Taf12 mutant embryos...
Source: Developmental Biology - April 9, 2024 Category: Biology Authors: Xinjian Doris He Shelby Phillips Kaito Hioki Prabin Dhangada Majhi Courtney Babbitt Kimberly D Tremblay Leonid A Pobezinsky Jesse Mager Source Type: research
From neural tube to spinal cord: The dynamic journey of the dorsal neuroepithelium
Dev Biol. 2024 Apr 4;511:26-38. doi: 10.1016/j.ydbio.2024.04.001. Online ahead of print.ABSTRACTIn a developing embryo, formation of tissues and organs is remarkably precise in both time and space. Through cell-cell interactions, neighboring progenitors coordinate their activities, sequentially generating distinct types of cells. At present, we only have limited knowledge, rather than a systematic understanding, of the underlying logic and mechanisms responsible for cell fate transitions. The formation of the dorsal aspect of the spinal cord is an outstanding model to tackle these dynamics, as it first generates the periph...
Source: Developmental Biology - April 5, 2024 Category: Biology Authors: Susanna Ventriglia Chaya Kalcheim Source Type: research
From neural tube to spinal cord: The dynamic journey of the dorsal neuroepithelium
Dev Biol. 2024 Apr 4;511:26-38. doi: 10.1016/j.ydbio.2024.04.001. Online ahead of print.ABSTRACTIn a developing embryo, formation of tissues and organs is remarkably precise in both time and space. Through cell-cell interactions, neighboring progenitors coordinate their activities, sequentially generating distinct types of cells. At present, we only have limited knowledge, rather than a systematic understanding, of the underlying logic and mechanisms responsible for cell fate transitions. The formation of the dorsal aspect of the spinal cord is an outstanding model to tackle these dynamics, as it first generates the periph...
Source: Developmental Biology - April 5, 2024 Category: Biology Authors: Susanna Ventriglia Chaya Kalcheim Source Type: research
From neural tube to spinal cord: The dynamic journey of the dorsal neuroepithelium
Dev Biol. 2024 Apr 3:S0012-1606(24)00090-3. doi: 10.1016/j.ydbio.2024.04.001. Online ahead of print.ABSTRACTIn a developing embryo, formation of tissues and organs is remarkably precise in both time and space. Through cell-cell interactions, neighboring progenitors coordinate their activities, sequentially generating distinct types of cells. At present, we only have limited knowledge, rather than a systematic understanding, of the underlying logic and mechanisms responsible for cell fate transitions. The formation of the dorsal aspect of the spinal cord is an outstanding model to tackle these dynamics, as it first generate...
Source: Developmental Biology - April 5, 2024 Category: Biology Authors: Susanna Ventriglia Chaya Kalcheim Source Type: research
From neural tube to spinal cord: The dynamic journey of the dorsal neuroepithelium
Dev Biol. 2024 Apr 3:S0012-1606(24)00090-3. doi: 10.1016/j.ydbio.2024.04.001. Online ahead of print.ABSTRACTIn a developing embryo, formation of tissues and organs is remarkably precise in both time and space. Through cell-cell interactions, neighboring progenitors coordinate their activities, sequentially generating distinct types of cells. At present, we only have limited knowledge, rather than a systematic understanding, of the underlying logic and mechanisms responsible for cell fate transitions. The formation of the dorsal aspect of the spinal cord is an outstanding model to tackle these dynamics, as it first generate...
Source: Developmental Biology - April 5, 2024 Category: Biology Authors: Susanna Ventriglia Chaya Kalcheim Source Type: research
C. elegans Afadin is required for epidermal morphogenesis and functionally interfaces with the cadherin-catenin complex and RhoGAP PAC-1/ARHGAP21
Dev Biol. 2024 Mar 29:S0012-1606(24)00089-7. doi: 10.1016/j.ydbio.2024.03.007. Online ahead of print.ABSTRACTDuring epithelial morphogenesis, the apical junctions connecting cells must remodel as cells change shape and make new connections with their neighbors. In the C. elegans embryo, new apical junctions form when epidermal cells migrate and seal with one another to encase the embryo in skin ('ventral enclosure'), and junctions remodel when epidermal cells change shape to squeeze the embryo into a worm shape ('elongation'). The junctional cadherin-catenin complex (CCC), which links epithelial cells to each other and to ...
Source: Developmental Biology - March 31, 2024 Category: Biology Authors: Allison E Hall Diana Klompstra Jeremy Nance Source Type: research
C. elegans Afadin is required for epidermal morphogenesis and functionally interfaces with the cadherin-catenin complex and RhoGAP PAC-1/ARHGAP21
Dev Biol. 2024 Mar 29:S0012-1606(24)00089-7. doi: 10.1016/j.ydbio.2024.03.007. Online ahead of print.ABSTRACTDuring epithelial morphogenesis, the apical junctions connecting cells must remodel as cells change shape and make new connections with their neighbors. In the C. elegans embryo, new apical junctions form when epidermal cells migrate and seal with one another to encase the embryo in skin ('ventral enclosure'), and junctions remodel when epidermal cells change shape to squeeze the embryo into a worm shape ('elongation'). The junctional cadherin-catenin complex (CCC), which links epithelial cells to each other and to ...
Source: Developmental Biology - March 31, 2024 Category: Biology Authors: Allison E Hall Diana Klompstra Jeremy Nance Source Type: research
C. elegans Afadin is required for epidermal morphogenesis and functionally interfaces with the cadherin-catenin complex and RhoGAP PAC-1/ARHGAP21
Dev Biol. 2024 Mar 29:S0012-1606(24)00089-7. doi: 10.1016/j.ydbio.2024.03.007. Online ahead of print.ABSTRACTDuring epithelial morphogenesis, the apical junctions connecting cells must remodel as cells change shape and make new connections with their neighbors. In the C. elegans embryo, new apical junctions form when epidermal cells migrate and seal with one another to encase the embryo in skin ('ventral enclosure'), and junctions remodel when epidermal cells change shape to squeeze the embryo into a worm shape ('elongation'). The junctional cadherin-catenin complex (CCC), which links epithelial cells to each other and to ...
Source: Developmental Biology - March 31, 2024 Category: Biology Authors: Allison E Hall Diana Klompstra Jeremy Nance Source Type: research
C. elegans Afadin is required for epidermal morphogenesis and functionally interfaces with the cadherin-catenin complex and RhoGAP PAC-1/ARHGAP21
Dev Biol. 2024 Mar 29:S0012-1606(24)00089-7. doi: 10.1016/j.ydbio.2024.03.007. Online ahead of print.ABSTRACTDuring epithelial morphogenesis, the apical junctions connecting cells must remodel as cells change shape and make new connections with their neighbors. In the C. elegans embryo, new apical junctions form when epidermal cells migrate and seal with one another to encase the embryo in skin ('ventral enclosure'), and junctions remodel when epidermal cells change shape to squeeze the embryo into a worm shape ('elongation'). The junctional cadherin-catenin complex (CCC), which links epithelial cells to each other and to ...
Source: Developmental Biology - March 31, 2024 Category: Biology Authors: Allison E Hall Diana Klompstra Jeremy Nance Source Type: research
