First person - Masayoshi Ko [FIRST PERSON]
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Masayoshi Ko is first author on ‘ Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver’, published in DMM. Masayoshi is an MD and PhD student in the lab of Kenya Kamimura and Shuji Terai at Niigata University, Japan, investigating the involvement of multi-organ linkage via autonomic nerves in non-alcoholic fatty liver (NAFLD)....
Source: DMM Disease Models and Mechanisms - March 28, 2021 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 28, 2021 Category: Biomedical Science Authors: Ko, M., Kamimura, K., Owaki, T., Nagoya, T., Sakai, N., Nagayama, I., Niwa, Y., Shibata, O., Oda, C., Morita, S., Kimura, A., Inoue, R., Setsu, T., Sakamaki, A., Yokoo, T., Terai, S. Tags: Metabolic Disorders RESEARCH ARTICLE Source Type: research

Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease [REVIEW]
ABSTRACT Birth defects contribute to ~0.3% of global infant mortality in the first month of life, and congenital heart disease (CHD) is the most common birth defect among newborns worldwide. Despite the significant impact on human health, most treatments available for this heterogenous group of disorders are palliative at best. For this reason, the complex process of cardiogenesis, governed by multiple interlinked and dose-dependent pathways, is well investigated. Tissue, animal and, more recently, computerized models of the developing heart have facilitated important discoveries that are helping us to understand the genet...
Source: DMM Disease Models and Mechanisms - March 28, 2021 Category: Biomedical Science Authors: Rufaihah, A. J., Chen, C. K., Yap, C. H., Mattar, C. N. Z. Tags: Developmental Disorders REVIEW Source Type: research

Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency [RESEARCH ARTICLE]
In conclusion, the UOX-KO rat is a great model to study hyperuricemia-related diseases. Hyperuricemia-induced autophagy and NLRP3-dependent inflammation are critically involved in the development of renal damage and, therefore, highlight the inhibition of autophagy and inflammation in search of therapeutic strategies to treat uric acid nephropathy. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 24, 2021 Category: Biomedical Science Authors: Wu, M., Ma, Y., Chen, X., Liang, N., Qu, S., Chen, H. Tags: Rat as a Disease Model RESEARCH ARTICLE Source Type: research

First person - Paco Lopez-Cuevas [FIRST PERSON]
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Paco López-Cuevas is first author on ‘Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis’, published in DMM. Paco is a PhD student in the lab of Paul Martin at the University of Bristol, Bristol, UK, investigating the role of inflammation in cancer progression. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 19, 2021 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 19, 2021 Category: Biomedical Science Authors: Lopez-Cuevas, P., Deane, L., Yang, Y., Hammond, C. L., Kague, E. Tags: Developmental Disorders, Zebrafish as a Disease Model RESEARCH ARTICLE Source Type: research

First person - Manh Tin Ho and Jiongming Lu [FIRST PERSON]
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Manh Tin Ho and Jiongming Lu are co-first authors on ‘A translation-independent activity of PheRS activates growth and proliferation in Drosophila’, published in DMM. Manh Tin conducted the research described in this article while a PhD student in the lab of Beat Suter at the University of Bern, Bern, Switzerland, and is now a postdoctoral researcher in the lab of Daniel Fuster at the University o...
Source: DMM Disease Models and Mechanisms - March 18, 2021 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

First person - Mugagga Kalyesubula and Ramgopal Mopuri [FIRST PERSON]
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Mugagga Kalyesubula and Ramgopal Mopuri are co-first authors on ‘High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition’, published in DMM. Mugagga is a PhD student in the lab of Dr Hay Dvir at the Volcani Center – Agricultural Research Organization (ARO), Rishon LeZion, Israel and The Hebrew University of Jerusalem, Rehovot, Israel, investi...
Source: DMM Disease Models and Mechanisms - March 18, 2021 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition [RESEARCH ARTICLE]
This article has an associated First Person interview with the joint first authors of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 18, 2021 Category: Biomedical Science Authors: Kalyesubula, M., Mopuri, R., Asiku, J., Rosov, A., Yosefi, S., Edery, N., Bocobza, S., Moallem, U., Dvir, H. Tags: Metabolic Disorders RESEARCH ARTICLE Source Type: research

A translation-independent function of PheRS activates growth and proliferation in Drosophila [RESEARCH ARTICLE]
This article has an associated First Person interview with the joint first authors of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 18, 2021 Category: Biomedical Science Authors: Ho, M. T., Lu, J., Brunssen, D., Suter, B. Tags: Drosophila as a Disease Model RESEARCH ARTICLE Source Type: research

Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation [RESEARCH ARTICLE]
ABSTRACT Myeloid-derived cells, in particular macrophages, are increasingly recognized as critical regulators of the balance of immunity and tolerance. However, whether they initiate autoimmune disease or perpetuate disease progression in terms of epiphenomena remains undefined. Here, we show that depletion of MCPIP1 in macrophages and granulocytes (Mcpip1fl/fl-LysMcre+ C57BL/6 mice) is sufficient to trigger severe autoimmune disease. This was evidenced by the expansion of B cells and plasma cells and spontaneous production of autoantibodies, including anti-dsDNA, anti-Smith and anti-histone antibodies. Consequently, we do...
Source: DMM Disease Models and Mechanisms - March 18, 2021 Category: Biomedical Science Authors: Dobosz, E., Lorenz, G., Ribeiro, A., Würf, V., Wadowska, M., Kotlinowski, J., Schmaderer, C., Potempa, J., Fu, M., Koziel, J., Lech, M. Tags: RESEARCH ARTICLE Source Type: research

First person - Aikta Sharma [FIRST PERSON]
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Aikta Sharma is first author on ‘Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition’, published in DMM. Aikta is a PhD student in the lab of Dr Claire E. Clarkin at the University of Southampton, Southampton, UK, investigating the role of osteoblast-derived vascular endothelial growth factor in bone matrix formation. (Source:...
Source: DMM Disease Models and Mechanisms - March 17, 2021 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition [RESOURCE ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 17, 2021 Category: Biomedical Science Authors: Sharma, A., Goring, A., Johnson, P. B., Emery, R. J. H., Hesse, E., Boyde, A., Olsen, B. R., Pitsillides, A. A., Oreffo, R. O. C., Mahajan, S., Clarkin, C. E. Tags: RESOURCE ARTICLE Source Type: research

First person - Ralitsa Madsen [FIRST PERSON]
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Ralitsa Madsen is first author on ‘NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells’, published in DMM. Ralitsa conducted the research described in this article while a member of Prof. Robert Semple's lab, initially as a PhD student at the Wellcome Trust-Medical Research Council Institute of Metabolic Science-Metabolic R...
Source: DMM Disease Models and Mechanisms - March 11, 2021 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

NODAL/TGF{beta} signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - March 11, 2021 Category: Biomedical Science Authors: Madsen, R. R., Longden, J., Knox, R. G., Robin, X., Völlmy, F., Macleod, K. G., Moniz, L. S., Carragher, N. O., Linding, R., Vanhaesebroeck, B., Semple, R. K. Tags: Stem Cells RESEARCH ARTICLE Source Type: research