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A Novel Approach of Polyvinyl Alcohol/Acrylic Acid Based Hydrogels for Controlled Delivery of Diclofenac Sodium
CONCLUSION: The results indicated that prepared PVA/AA hydrogels can be used as an alternative approach for the controlled delivery of diclofenac sodium.PMID:38623980 | DOI:10.2174/0113892010296120240327055943 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 16, 2024 Category: Biotechnology Authors: Muhammad Suhail Syed Faisal Badshah I-Hui Chiu Arif Ullah Arshad Khan Hamid Ullah Noorah Saleh Al-Sowayan Ming-Jun Tsai Pao-Chu Wu Source Type: research

SiRNA-Mediated Knockdown of ABCB1 Enhances the Efficacy of Doxorubicin and Vinorelbine in Breast Cancer Cells
CONCLUSION: these findings suggest that combining siRNA, doxorubicin, and vinorelbine holds promise as a therapeutic strategy to overcome ABCB1-mediated multidrug resistance in breast cancer. Further investigations and clinical trials are warranted to evaluate its clinical efficacy rigorously.PMID:38616741 | DOI:10.2174/0113892010284774240328144105 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 15, 2024 Category: Biotechnology Authors: Zahra Abbasfard Abbas Behzad-Behbahani Banafshe Rastegari Sirous Naeimi Mehdi Moghanibashi Fatemeh Safari Source Type: research

Nanodelivery Approaches of Phytoactives for Skin Cancers: Current and Future Perspectives
Curr Pharm Biotechnol. 2024 Apr 9. doi: 10.2174/0113892010300081240329033208. Online ahead of print.ABSTRACTIn recent years, there has been an increase in skin cancers due to external factors, especially environmental factors, and studies on treatment alternatives have gained importance. Nanomaterials are common, from sunscreen formulas to formulations designed to treat skin cancers at various stages. Using bioactives has multiple effects in treating skin cancers, which provides many advantages. In this regard, many phytochemicals gain importance with their antioxidant, anti-proliferative, anti-inflammatory, antiangiogenic...
Source: Current Pharmaceutical Biotechnology - April 15, 2024 Category: Biotechnology Authors: Evren Alg ın Yapar Merve Nur Özdemir Meltem Ezgi Durgun Özlem Akbal Dağıstan Simona Cavalu Y ıldız Özsoy Murat Kartal Source Type: research

Exploring the Therapeutic Potential of Flavonoids in the Management of Cancer
Curr Pharm Biotechnol. 2024 Apr 8. doi: 10.2174/0113892010297456240327062614. Online ahead of print.ABSTRACTFlavonoids are a class of polyphenolic compounds that can be classified into six distinct categories, namely isoflavonoids, flavanones, flavanols, flavonols, flavones, and anthocyanidins. These compounds are naturally occurring and can be found in a diverse range of plant species. Flavonoids, a class of bioactive compounds, are mostly obtained through the consumption of vegetables, fruits and plant-derived beverages such as wine, cocoa-based products and green tea. Flavonoids have been demonstrated to exhibit a diver...
Source: Current Pharmaceutical Biotechnology - April 9, 2024 Category: Biotechnology Authors: Sonia Singh Riya Verma Source Type: research

The Treatment of Tubal Inflammatory Infertility using Yinjia Tablets through EGFR/MEK/ERK Signaling Pathway based on Network Pharmacology
Conclusion: This study revealed that YJP Reducing tubal inflammation and promoting tissue repair may be associated with inhibition of the EGFR/MEK/ERK signaling pathway.</p>.PMID:38572608 | DOI:10.2174/0113892010234591230919074245 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 4, 2024 Category: Biotechnology Authors: Yefang Huang Zhelin He Hang Zhou Yi Wen Xiaoli Ji Weijun Ding Boyu Zhu Yongqing Zhang Ying Tan Kun Yang Yan Wang Source Type: research

Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant
Curr Pharm Biotechnol. 2024 Apr 1. doi: 10.2174/0113892010287720240322060706. Online ahead of print.ABSTRACTWound healing is crucial for maintaining skin integrity and preventing complications from external threats. Various plants, such as Achillea millefolium, Aloe vera, Curcuma longa, Calendula officinalis, Camellia sinensis, Azadirachta indica, and Plantago, have demonstrated wound healing capabilities and have been used in herbal medicine for wound care. NLCs are second-generation lipid nanoparticles, blending solid and liquid lipids to improve medication loading and limit leakage. NLCs have been used in various applic...
Source: Current Pharmaceutical Biotechnology - April 3, 2024 Category: Biotechnology Authors: Aditya Jain Shikha Yadav Javed Khan Source Type: research

A Comprehensive Review on Nanoparticles as Drug Delivery System and Their Role for Management of Hypertension
Curr Pharm Biotechnol. 2024 Apr 2. doi: 10.2174/0113892010291414240322112508. Online ahead of print.ABSTRACTThe current global epidemic of hypertension is not a disease in and of itself but rather a significant risk factor for serious cardiovascular conditions such as peripheral artery disease, heart failure, myocardial infarction, and stroke. Although many medications that work through various mechanisms of action are available on the market in conventional formulations to treat hypertension, these medications face significant difficulties with their bioavailability, dosing, and associated side effects, which significantl...
Source: Current Pharmaceutical Biotechnology - April 3, 2024 Category: Biotechnology Authors: None Prerna Dinesh Chandra Bhatt Khalid Basir Mir Vikash Kumar Sandeep Rathor Source Type: research