Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma
Curr Med Chem. 2024 Apr 16. doi: 10.2174/0109298673268206240405084558. Online ahead of print.ABSTRACTPleural mesothelioma is a rare neoplastic disease with aggressive features. Patient survival is poor due to the lack of early symptoms and the absence of effective therapeutic strategies. The development of pleural mesothelioma is mainly associated with asbestos exposure and related chronic inflammation. From a molecular-based perspective, this disease is a heterogeneous tumor lacking actionable alterations. The median overall survival of patients affected by this tumor does not exceed 16 months from diagnosis. Molecular an...
Source: Current Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Luca Mirra Giovanni L Beretta Daniela Lisini Angela Marcianti Eleonora Spampinato Cristina Corno Matteo Costantino Angelo Corsico Giulia Maria Stella Paola Perego Source Type: research
Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma
Curr Med Chem. 2024 Apr 16. doi: 10.2174/0109298673268206240405084558. Online ahead of print.ABSTRACTPleural mesothelioma is a rare neoplastic disease with aggressive features. Patient survival is poor due to the lack of early symptoms and the absence of effective therapeutic strategies. The development of pleural mesothelioma is mainly associated with asbestos exposure and related chronic inflammation. From a molecular-based perspective, this disease is a heterogeneous tumor lacking actionable alterations. The median overall survival of patients affected by this tumor does not exceed 16 months from diagnosis. Molecular an...
Source: Current Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Luca Mirra Giovanni L Beretta Daniela Lisini Angela Marcianti Eleonora Spampinato Cristina Corno Matteo Costantino Angelo Corsico Giulia Maria Stella Paola Perego Source Type: research
Novel Natural Inhibitors for Glioblastoma by Targeting Epidermal Growth Factor Receptor and Phosphoinositide 3-kinase
CONCLUSION: This study has identified novel natural products that inhibit the progression of glioblastoma; however, further examinations of these molecules are required in animal and tissue models to better understand their downstream targeting mechanisms.PMID:38616761 | DOI:10.2174/0109298673293279240404080046 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Atta Ullah Saeed Ullah Muhammad Waqas Majid Khan Najeeb Ur Rehman Asaad Khalid Afnan Jan Shahkar Aziz Muhammad Naeem Sobia Halim Ajmal Khan Ahmed Al-Harrasi Source Type: research
Novel Natural Inhibitors for Glioblastoma by Targeting Epidermal Growth Factor Receptor and Phosphoinositide 3-kinase
CONCLUSION: This study has identified novel natural products that inhibit the progression of glioblastoma; however, further examinations of these molecules are required in animal and tissue models to better understand their downstream targeting mechanisms.PMID:38616761 | DOI:10.2174/0109298673293279240404080046 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Atta Ullah Saeed Ullah Muhammad Waqas Majid Khan Najeeb Ur Rehman Asaad Khalid Afnan Jan Shahkar Aziz Muhammad Naeem Sobia Halim Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Epigenetic Impact of Curcumin and Thymoquinone on Cancer Therapeutics
Curr Med Chem. 2024 Apr 4. doi: 10.2174/0109298673288542240327112351. Online ahead of print.ABSTRACTToday, one of the most prevalent reasons for death among people is carcinoma. Because it is still on the increase throughout the world, there is a critical need for in- -depth research on the pathogenic mechanisms behind the disease as well as for efficient treatment. In the field of epigenetics, gene expression alterations that are inherited but not DNA sequence changes are investigated. Three key epigenetic changes, histone modifications, DNA methylation and non-coding RNA (ncRNA) expression, are principally responsible fo...
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Vikas Kumar Roohi Kesharwani Dilip K Patel Amita Verma Mohamed Gamil Mehanna Ayman Mohammad Azizah Salim Bawadood Fahad A Alabassi Firoz Anwar Source Type: research
Design of PI3K-mTOR Dual Inhibitors for Ovarian Cancer: Are We on the Right Track?
Curr Med Chem. 2024 Apr 4. doi: 10.2174/0109298673293028240326051835. Online ahead of print.ABSTRACTOvarian cancer is one of the most familiar kinds of gynecological cancer seen in women. Though it is not as familiar as breast cancer, the survival rate for ovarian cancer is very low when compared with breast cancer. Even after being one among the familiar types, to date, there are no proper treatments available for ovarian cancer. All the treatments that are present currently show a high rate of recurrence after the treatment. Therefore, treating this silent killer from the roots is the need of the hour. PI3K/AKT/m- TOR pa...
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Shenoy K Mangala Ekta Rathi Karthik S Udupa Prasada K Shama K Sreedhara Ranganath Pai Suvarna G Kini Source Type: research
Research Trends in Proteomic Studies Using Serum from COVID-19 Patients: A Bibliometric Analysis
Curr Med Chem. 2024 Apr 5. doi: 10.2174/0109298673286915240329063441. Online ahead of print.ABSTRACTThe COVID-19 pandemic significantly impacted the global populace, resulting in a staggering number of deaths across the globe. New approaches and biomarkers to evaluate disease progression are crucial for improving disease management. In this context, serum proteomics has emerged as a promising tool for identifying molecular alterations related to COVID-19. This work carried out a bibliometric evaluation of the current status and trends of studies applying serum proteomics to COVID-19 subjects. The search was performed using...
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Érika Alves da Fonsêca Amorim Roberval Nascimento Moraes Neto Ana Viviam Souza Camila Guerra Martinez Adrielle Zagmignan Lu ís Cláudio Nascimento da Silva Source Type: research
Identification and Functional Characterization of Essential Genes Related to Gefitinib Sensitivity in Lung Adenocarcinoma
CONCLUSIONS: This study identified 7 critical genes related to gefitinib sensitivity in LUAD. Functionally, genes positively correlated with gefitinib sensitivity might regulate the progression of LUAD through the immune, cell cycle, and metabolic pathways and showed potential effects in predicting sensitivity to different drugs. These findings help offer a theoretical direction for personalized treatment of LUAD.PMID:38584557 | DOI:10.2174/0109298673276881240111172756 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Rui Wang Lu Zhang Source Type: research
Structural Basis of HIV-1 gp41 N-trimer for Designing Bifunctional Peptide-based Fusion Inhibitors
CONCLUSION: Moreover, this strategy can be used to investigate antivirals against unknown viruses for future outbreaks.PMID:38584558 | DOI:10.2174/0109298673291459240328074404 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Jinlin Wang Peiying Li Ruijuan Li Guodong Liang Yuheng Ma Heiya Na Source Type: research
Epigenetic Impact of Curcumin and Thymoquinone on Cancer Therapeutics
Curr Med Chem. 2024 Apr 4. doi: 10.2174/0109298673288542240327112351. Online ahead of print.ABSTRACTToday, one of the most prevalent reasons for death among people is carcinoma. Because it is still on the increase throughout the world, there is a critical need for in- -depth research on the pathogenic mechanisms behind the disease as well as for efficient treatment. In the field of epigenetics, gene expression alterations that are inherited but not DNA sequence changes are investigated. Three key epigenetic changes, histone modifications, DNA methylation and non-coding RNA (ncRNA) expression, are principally responsible fo...
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Vikas Kumar Roohi Kesharwani Dilip K Patel Amita Verma Mohamed Gamil Mehanna Ayman Mohammad Azizah Salim Bawadood Fahad A Alabassi Firoz Anwar Source Type: research
