Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis
To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-nega... (Source: Critical Care)
Source: Critical Care - April 16, 2024 Category: Intensive Care Authors: Milo Gatti, Pier Giorgio Cojutti and Federico Pea Tags: Research Source Type: research
Contribution of electrical impedance tomography to personalize positive end-expiratory pressure under ECCO2R
Extracorporeal Carbon Dioxide Removal (ECCO2R) is used in acute respiratory distress syndrome (ARDS) patients to facilitate lung-protective ventilatory strategies. Electrical Impedance Tomography (EIT) allows ind... (Source: Critical Care)
Source: Critical Care - April 16, 2024 Category: Intensive Care Authors: Benjamin Pequignot, Alain Combes, Mickael Lescroart, Bruno Levy and Matthieu Koszutski Tags: Brief Report Source Type: research
Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial
Randomized data evaluating the impact of the extracorporeal cardiopulmonary resuscitation (ECPR) approach on long-term clinical outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA) are la... (Source: Critical Care)
Source: Critical Care - April 16, 2024 Category: Intensive Care Authors: Daniel Rob, Klaudia Farkasovska, Marketa Kreckova, Ondrej Smid, Petra Kavalkova, Jaromir Macoun, Michal Huptych, Petra Havrankova, Juraj Gallo, Jan Pudil, Milan Dusik, Stepan Havranek, Ales Linhart and Jan Belohlavek Tags: Research Source Type: research
Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis
The relationship between smoking and the risk of acute respiratory distress syndrome (ARDS) has been recognized, but the conclusions have been inconsistent. This systematic review and meta-analysis investigate... (Source: Critical Care)
Source: Critical Care - April 14, 2024 Category: Intensive Care Authors: Lujia Zhang, Jiahuan Xu, Yue Li, Fanqi Meng and Wei Wang Tags: Research Source Type: research
Correction to: Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study
(Source: Critical Care)
Source: Critical Care - April 12, 2024 Category: Intensive Care Authors: Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizio Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao and Rajesh Mishra Tags: Correction Source Type: research
Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study
Sepsis is associated with high morbidity and mortality, primarily due to systemic inflammation-induced tissue damage, resulting organ failure, and impaired recovery. Regulated extracellular matrix (ECM) turnov... (Source: Critical Care)
Source: Critical Care - April 12, 2024 Category: Intensive Care Authors: YiWen Fan, Jill Moser, Matijs van Meurs, Dorien Kiers, Jannie Marie B ülow Sand, Diana Julie Leeming, Peter Pickkers, Janette K. Burgess, Matthijs Kox and Janesh Pillay Tags: Research Source Type: research
Job description and perception of clinical research personnel working in a network of French intensive care units
There is a lack of information about the organisation and management of clinical research personnel in Europe and of their professional activity in intensive care. We therefore conducted a cross-sectional surv... (Source: Critical Care)
Source: Critical Care - April 11, 2024 Category: Intensive Care Authors: Mireille Adda, Claire Dupuis, G érald Gouby, Claude Dubray, Jean Reignier, Bertrand Souweine and Christian Dualé Tags: Research Source Type: research
Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies
Anemia is a hallmark of critical illness, which is largely inflammatory driven. We hypothesized that the use of anti-inflammatory agents limits the development of anemia and reduces the need for red blood cell... (Source: Critical Care)
Source: Critical Care - April 9, 2024 Category: Intensive Care Authors: Madelief Bolscher, Stephanie C. E. Koster, Matty Koopmans, Jelle L. G. Haitsma Mulier, Lennie P. G. Derde and Nicole P. Juffermans Tags: Research Source Type: research
Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study
Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation is a proarrhythmic state which reflects myocardial injury in a group of heterogeneous disorders. However, the study on the ... (Source: Critical Care)
Source: Critical Care - April 9, 2024 Category: Intensive Care Authors: Weizhuo Liu, Rongjiao Shao, Shen Zhang, Lei Jin, Rongchen Liu, Peidong Chen, Jintao Hu, Haocheng Ma, Bangwei Wu, Weiguo Liang, Xinping Luo, Jian Li, Weiming Chen, Nanqing Xiong and Bin He Tags: Research Source Type: research
Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest
The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA), includi... (Source: Critical Care)
Source: Critical Care - April 9, 2024 Category: Intensive Care Authors: Isabelle Arctaedius, Helena Levin, Bergth óra Thorgeirsdóttir, Marion Moseby-Knappe, Tobias Cronberg, Martin Annborn, Niklas Nielsen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Attila Frigyesi, Hans Friberg, Anna Lybeck and Niklas Mattsson-Carl Tags: Research Source Type: research
Correction: Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort
(Source: Critical Care)
Source: Critical Care - April 9, 2024 Category: Intensive Care Authors: Louis ‑Marie Galerneau, Sebastien Bailly, Nicolas Terzi, Stephane Ruckly, Maite Garrouste‑Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean‑Marie Forel, Anais Dartevel, Julien Dessajan, Christophe Adrie, D Tags: Correction Source Type: research
Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images
This study aimed to develop an automated method to measure the gray-white matter ratio (GWR) from brain computed tomography (CT) scans of patients with out-of-hospital cardiac arrest (OHCA) and assess its sign... (Source: Critical Care)
Source: Critical Care - April 9, 2024 Category: Intensive Care Authors: Hsinhan Tsai, Chien-Yu Chi, Liang-Wei Wang, Yu-Jen Su, Ya-Fang Chen, Min-Shan Tsai, Chih-Hung Wang, Cheyu Hsu, Chien-Hua Huang and Weichung Wang Tags: Research Source Type: research
Use of artificial intelligence in critical care: opportunities and obstacles
Perhaps nowhere else in the healthcare system than in the intensive care unit environment are the challenges to create useful models with direct time-critical clinical applications more relevant and the obstac... (Source: Critical Care)
Source: Critical Care - April 8, 2024 Category: Intensive Care Authors: Michael R. Pinsky, Armando Bedoya, Azra Bihorac, Leo Celi, Matthew Churpek, Nicoleta J. Economou-Zavlanos, Paul Elbers, Suchi Saria, Vincent Liu, Patrick G. Lyons, Benjamin Shickel, Patrick Toral, David Tscholl and Gilles Clermont Tags: Perspective Source Type: research
Effects of robotic-assisted early mobilization versus conventional mobilization in intensive care unit patients: prospective interventional cohort study with retrospective control group analysis
Approximately one in three survivors of critical illness suffers from intensive-care-unit-acquired weakness, which increases mortality and impairs quality of life. By counteracting immobilization, a known risk... (Source: Critical Care)
Source: Critical Care - April 6, 2024 Category: Intensive Care Authors: Lucas Huebner, Angelika Warmbein, Christina Scharf, Ines Schroeder, Kirsi Manz, Ivanka Rathgeber, Marcus Gutmann, Johanna Biebl, Amrei Mehler-Klamt, Jana Huber, Inge Eberl, Eduard Kraft, Uli Fischer and Michael Zoller Tags: Brief Report Source Type: research
GFAP point-of-care measurement for prehospital diagnosis of intracranial hemorrhage in acute coma
Prehospital triage and treatment of patients with acute coma is challenging for rescue services, as the underlying pathological conditions are highly heterogenous. Recently, glial fibrillary acidic protein (GF... (Source: Critical Care)
Source: Critical Care - April 5, 2024 Category: Intensive Care Authors: Sabina Zylyftari, Sebastian Luger, Kristaps Blums, Stephan Barthelmes, Sebastian Humm, Hannsj örg Baum, Stephan Meckel, Jörg Braun, Gregor Lichy, Andreas Heilgeist, Love-Preet Kalra and Christian Foerch Tags: Research Source Type: research
