Effectiveness and safety of filgotinib in rheumatoid arthritis patients: data from the GISEA registry
CONCLUSIONS: In an Italian real-life setting, filgotinib is confirmed to be safe and with a good effectiveness profile both in monotherapy and without glucocorticoids.PMID:38634362 | DOI:10.55563/clinexprheumatol/b40rv4 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Marco Fornaro Roberto Caporali Martina Biggioggero Serena Bugatti Ludovico De Stefano Alberto Cauli Mattia Congia Fabrizio Conti Maria Sole Chimenti Chiara Bazzani Simone Perniola Fabiola Atzeni Giovanni Lapadula Gianfranco Ferraccioli Florenzo Iannone fr Source Type: research

Uncovering risk factors for adverse events and infections in rheumatoid arthritis and rheumatoid arthritis with interstitial lung disease under treatment with biologics or targeted synthetic DMARDs: insights from the KOBIO Registry
CONCLUSIONS: Patients with RA-ILD exhibited a higher rate of b/tsDMARDs withdrawal due to overall AEs and infections than those with RA without ILD. In the RA-ILD group, older age was identified as a risk factor for overall AEs, whereas a current smoking status was identified as a risk factor for infections.PMID:38634363 | DOI:10.55563/clinexprheumatol/6h1euo (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Ji-Won Kim Kichul Shin Juyang Jung Chang-Hee Suh Jinhyun Kim Sun-Kyung Lee Hyoun-Ah Kim Source Type: research

Endothelial mesenchymal transition promotes pannus formation in ankylosing spondylitis by  activation of TGF-β/SMAD signalling pathway
CONCLUSIONS: Our findings show that EndMT is involved in the promotion of pannus formation by TGF-β/SMAD signalling pathway activation in AS.PMID:38634365 | DOI:10.55563/clinexprheumatol/9u1vzp (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Shaojie Li Zhiduo Hou Yao Gong Jianhua Peng Hongjin Liang Danmin Wang Ling Lin Source Type: research

Analysis of risk factors associated with diffuse alveolar haemorrhage in patients with ANCA-associated vasculitis and construction of a risk prediction model using line graph
CONCLUSIONS: The new nomogram, which included age, Hb, ESR, PLT and haematuria as variables, had the potential to predict the risk of AAV patients complicated with DAH.PMID:38634373 | DOI:10.55563/clinexprheumatol/7m21vr (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Xuanwei Li Congyuan Ma Jiamei Xu Meng Zhang Qin Xiang Yue Li Wenlai Li Ping Zhu Source Type: research

Lower total cholesterol and triglyceride levels in ankylosing spondylitis than non-inflammatory rheumatic disease controls in a 1978-98 study: a potential effect of increased physical energetics in manual occupations in the pre-2000 chronologic era
CONCLUSIONS: In the 1978-98 survey, AS had significantly lower mean serum cholesterol and triglyceride levels than NIRD control patients. Associated manual labour occupations may have significantly contributed to results, possibly related to increased energy expenditures from physical activity in the pre-2000 era.PMID:38634375 | DOI:10.55563/clinexprheumatol/u41mn1 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Alfonse T Masi Ponnaiah C Mohan Tsr Murugan Chadrick R Evans Michael J Ryan Megan L Brezka Vaughn Hanna Gerald R Cooper Jean C Aldag Source Type: research

Plasma amino acid concentration in patients with IgG4-related disease
Clin Exp Rheumatol. 2024 Apr 5. doi: 10.55563/clinexprheumatol/std9t8. Online ahead of print.NO ABSTRACTPMID:38607674 | DOI:10.55563/clinexprheumatol/std9t8 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Hiroyuki Nakamura Masatoshi Kanda Hidenori Amaike Ken Nagahata Hiroki Takahashi Source Type: research

Comment on unexpectedly high prevalence of primary immune deficiency in fibromyalgia: serologic features and clinical correlates
Clin Exp Rheumatol. 2024 Apr 8. doi: 10.55563/clinexprheumatol/xpxylh. Online ahead of print.NO ABSTRACTPMID:38607676 | DOI:10.55563/clinexprheumatol/xpxylh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Mustafa Ilker Inan Yasemin Akgul Balaban Source Type: research

Fibromyalgia: one year in review 2024
This article summarises the main advances in FM during the last year. Even in 2023, research on FM was notably active. From a clinimetric perspective, studies have been conducted to evaluate the possibilities of interchanging the primary indices of disease severity, primarily for studies with substantial case numbers. Regarding FM pathogenesis, ongoing research focuses on small fiber neuropathy: some studies have documented its association with central sensitisation, while others have revealed distinct sensory profiles in patients with FM and small fiber neuropathy compared to those solely with small fiber neuropathy. Dors...
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Marco Di Carlo Benedetta Bianchi Fausto Salaffi Greta Pellegrino Cristina Iannuccelli Valeria Giorgi Piercarlo Sarzi-Puttini Source Type: research

Central sensitivity in fibromyalgia: testing a model to explain the role of psychological factors on functioning and quality of life
CONCLUSIONS: The study underscores the pivotal role of psychological dimensions in influencing CS levels and their relationships with QoL in patients with FM.PMID:38607679 | DOI:10.55563/clinexprheumatol/h8jgv3 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Filippo Maria Nimbi Alessia Renzi Erika Limoncin Sara Francesca Bongiovanni Piercarlo Sarzi-Puttini Federica Galli Source Type: research

The Joint Vasculitis Registry in German-speaking countries (GeVas): subgroup analysis of 266 AAV-patients
CONCLUSIONS: Demographic characteristics are comparable to those in other European countries. Differences were found regarding ANCA status, frequencies of organ manifestations, and therapeutic regimens. The GeVas registry will allow longitudinal observations and prospective outcome measures in AAV.PMID:38607682 | DOI:10.55563/clinexprheumatol/suxkyq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Sabrina Arnold Pia Wallmeier Arlette Tais Gabriele Ihorst Marco Janoschke Fabian Schubach Peer Aries Raoul Bergner Jan Phillip Bremer Norman G örl Eva Gutdeutsch Bernhard Hellmich J örg Henes Bimba Franziska Hoyer Antje Kangowski Ina K ötter Martin Kru Source Type: research

Fibromyalgia and hyperlipidaemia: a balance between cardiovascular risk reduction and muscular side effects
Clin Exp Rheumatol. 2024 Apr 8. doi: 10.55563/clinexprheumatol/go94gq. Online ahead of print.NO ABSTRACTPMID:38607683 | DOI:10.55563/clinexprheumatol/go94gq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Francesco Sbrana Beatrice Dal Pino Source Type: research

Cancer-associated myositis before and after the COVID-19 pandemic onset: a comment
Clin Exp Rheumatol. 2024 Apr 8. doi: 10.55563/clinexprheumatol/mxdet4. Online ahead of print.NO ABSTRACTPMID:38607684 | DOI:10.55563/clinexprheumatol/mxdet4 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Hinpetch Daungsupawong Viroj Wiwanitkit Source Type: research

Validation of Qualisex questionnaire to evaluate sexual dysfunction in women affected by fibromyalgia
CONCLUSIONS: This study validated Qualisex questionnaire as a good test for the sexual disorders' evaluation in FM women. Its use allows the assessment of different factors associated with sexual dysfunction, showing an impact of FM on sexuality. Moreover, due to demotivation feelings, sexual dysfunction contributes to worsen patients' quality of life.PMID:38607686 | DOI:10.55563/clinexprheumatol/a00yur (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Chiara Gioia Giulio Dolcini Cristina Iannuccelli Martina Favretti Daniele Franculli Piercarlo Sarzi-Puttini Fabrizio Conti Roberta Priori Manuela Di Franco Source Type: research

Autoantibodies in post-treatment Lyme disease and association with clinical symptoms
CONCLUSIONS: Several autoantibodies were found after Borrelia burgdorferi and SARS-CoV2 infection, although the prevalence was similar in those with persistent symptoms and those who returned to health. While our data show no difference in autoantibody prevalence across the four post-infectious states, we do not imply that autoantibodies are irrelevant in this setting. Rather, this study highlights the need for novel antibody discovery in larger cohorts of well-defined patient populations.PMID:38607687 | DOI:10.55563/clinexprheumatol/qcupkk (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Marzieh Keshtkarjahromi Alison W Rebman Annukka A R Antar Yukari C Manabe Laura Gutierrez-Alamillo Livia A Casciola-Rosen John N Aucott John B Miller Source Type: research

Association between Life's Essential 8 and all-cause or cardiovascular-specific mortality in patients with rheumatoid arthritis
CONCLUSIONS: CVH measured by the LE8 score is a robust and independent predictor of all-cause mortality among U.S. RA patients.PMID:38607691 | DOI:10.55563/clinexprheumatol/ppsp71 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Xiufang Kong Wei Wang Source Type: research