Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Evaluation of Insulin Dosing Strategies for Hyperkalemia Management at an Academic Medical Center
Clin Ther. 2024 Apr 8:S0149-2918(24)00070-5. doi: 10.1016/j.clinthera.2024.03.003. Online ahead of print.ABSTRACTPURPOSE: While intravenous (IV) insulin is often administered at a fixed dose of 10 units for acute hyperkalemia, optimal dosing for minimizing hypoglycemia while effectively reversing hyperkalemia has not been established. The purpose of this analysis was to evaluate the effect of insulin dosing strategies on hypoglycemia in patients with hyperkalemia.METHODS: Adult patients presenting to an academic medical center who received IV insulin for hyperkalemia between 2016 and 2020 were retrospectively identified. P...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Meghan E Cook Lena K Tran Jeremy R DeGrado Afrah Alkazemi Kaylee K Marino Source Type: research
The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Clin Ther. 2024 Apr 8:S0149-2918(24)00068-7. doi: 10.1016/j.clinthera.2024.03.002. Online ahead of print.ABSTRACTPURPOSE: L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS: PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean dif...
Source: Clinical Therapeutics - April 9, 2024 Category: Drugs & Pharmacology Authors: Amin Mirrafiei Ahmad Jayedi Sakineh Shab-Bidar Source Type: research
Comparing the Effect of Early Versus Delayed Metformin Treatment on Glycaemic Parameters Among Australian Adults With Incident Diabetes: Evidence Using a National General Practice Database
Clin Ther. 2024 Apr 1:S0149-2918(24)00067-5. doi: 10.1016/j.clinthera.2024.03.001. Online ahead of print.ABSTRACTPURPOSE: To compare the effect of early vs delayed metformin treatment for glycaemic management among patients with incident diabetes.METHODS: Cohort study using electronic health records of regular patients (1+ visits per year in 3 consecutive years) aged 40+ years with 'incident' diabetes attending Australian general practices (MedicineInsight, 2011-2018). Patients with incident diabetes were defined as those who had a) 12+ months of medical data before the first recording of a diabetes diagnosis AND b) a diag...
Source: Clinical Therapeutics - April 2, 2024 Category: Drugs & Pharmacology Authors: Mingyue Zheng Mumtaz Begum Carla De Oliveira Bernardo Nigel Stocks David Gonzalez-Chica Source Type: research
