How can clinicians enhance self-efficacy beliefs in osteoarthritis? An overview of systematic reviews with meta-analysis
AbstractThis overview of reviews aimed to synthesize the effectiveness of non-pharmacological approaches to enhance self-efficacy in people with osteoarthritis. The CINAHL, Embase, PsycINFO, PubMed, SPORTDiscus, and the Cochrane Library databases were searched from inception to December 2023. We considered systematic reviews with meta-analysis of randomized clinical trials evaluating any non-pharmacological intervention. We used AMSTAR 2 to assess the methodological quality of reviews. The overlap between reviews was calculated. We included eight systematic reviews with meta-analysis evaluating 30 different clinical trials...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
ConclusionsPatients with SLE with lytic EBV infection have higher disease activity and take longer to achieve remission. Our study furthers our understanding of the relationship between SLE and EBV infection and may inform better treatment practices in the future. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsA comprehensive analysis revealed that tofacitinib has a positive effect on addressing skin and joint symptoms, as well as improving the quality of life for patients with chronic plaque psoriasis and psoriatic arthritis (PsA). However, the safety of the drug ’s long-term usage even requires further validation.Key Points• In 6 analyses involving a total of 1393 patients, tofacitinib exhibits positive effect on the treatment of both chronic plaque psoriasis and psoriatic arthritis (PsA).• Although dose-based subgroup analyses have demonstrated effectiveness. Some studies indicate that the 5-mg dose (twice da...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database
ConclusionTogether,EPSTI1 was found to be a potential biomarker for SLE, closely related to T cell immune imbalance.Key Points• EPSTI1 expression was significantly increased in PBMCs of SLE patients.• EPSTI1 was positively correlated with disease activity and T cell activation- or differentiation-associated genes in SLE patients.• EPSTI1 might have a good diagnostic value for SLE. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Raman spectroscopic analysis of joint capsule calcification of the fingers
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Male patients with primary Sj ögren’s syndrome have unique clinical manifestations and circulating lymphocyte profiles
ConclusionsMale patients with pSS have distinctive peripheral blood lymphocyte subpopulations, present with more severe clinical symptoms and immunological features, and have an unfavorable prognosis.Key Points• Male patients with pSS have more severe clinical symptoms and specific characteristics of peripheral blood lymphocyte subsets.• Male pSS patients exhibit a higher intensity of the disease (as evaluated by ESSDAI).• Male patients with pSS require individualized treatment regimens and closer follow-up. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 11, 2024 Category: Rheumatology Source Type: research
Characteristics of the oral microbiota in patients with primary Sj ögren’s syndrome
ConclusionsThe oral microbial ecology of patients with pSS is dysregulated, resulting in a decrease in overall diversity.Prevotella andVeillonella may be related to pSS, whileFusobacterium,Actinomyces, andLeptotrichia may be related to dental caries in pSS patients.Key Points•This study revealed differences in the oral microbial composition of patients with pSS compared to healthy controls.•We included a plaque group of pSS patients to identify the microbiota related to pSS and dental caries.•Prevotella and Veillonella may contribute to pSS, and Fusobacterium,Actinomyces, and Leptotrichia are associated with dental c...
Source: Clinical Rheumatology - April 11, 2024 Category: Rheumatology Source Type: research
Latent class analysis of psychological resilience and influencing factors in patients with rheumatoid arthritis: a cross-sectional survey
ConclusionThree classes of RA patients ’ psychological resilience were identified by this study, and these classes were strongly correlated with individual treatment components. It is crucial to take into account the psychological resiliency of female RA patients who do not have a job. In order to improve psychological resilience, heal thcare staff should first increase their comprehension of treat-to-target. Furthermore, people with RA may become more psychologically resilient if they receive more social support.Key Points•Preliminary research found that psychological resilience in RA patients was associated with thre...
Source: Clinical Rheumatology - April 10, 2024 Category: Rheumatology Source Type: research
Elevated serum 25-hydroxyvitamin D: a potential indicator of remission in Takayasu arteritis patients with normal ESR and CRP levels
ConclusionSerum 25(OH)D levels significantly increased after treatment in TAK patients, and an increase of ≥ 8.45 µg/L was predictive of disease remission, especially in individuals with normal baseline ESR and/or CRP levels.Key Points• Following treatment, there was a significant increase in serum 25(OH)D levels among TAK patients.• The elevated changes in 25(OH)D levels before and after treatment demonstrated a positive correlation with the reduction in disease activity scores.• In patients with TAK before and after treatment, an elevation in serum 25(OH)D levels exceeding 8.45 µg/L serves as an indicato...
Source: Clinical Rheumatology - April 10, 2024 Category: Rheumatology Source Type: research
Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation
ConclusionMonitoring PsA disease activity can be improved by considering RDW and MPV as reliable indicators and using them to screen for psoriatic enthesopathy with MSUS indices.Key points•Clinically identifying enthesitis in patients with PsA can be challenging. Imaging MSUS indices hold promise for objective analysis, but there is no consensus on which indices to use in clinical trials and daily practice.•Patients with psoriatic enthesopathy have higher RDW and MPV levels, which are positively correlated with DAPSA28 score.•RDW and MPV can be considered in the turn of improved screening of psoriatic enthesopathy...
Source: Clinical Rheumatology - April 8, 2024 Category: Rheumatology Source Type: research
An externally validated clinical-laboratory nomogram for myocardial involvement in adult idiopathic-inflammatory-myopathy patients
ConclusionThis study developed and validated a nomogram model to predict the risk of MI in adult IIMs patients, which can benefit the prediction and early identification of MI as well as timely intervention in these patients. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 8, 2024 Category: Rheumatology Source Type: research
Letter to the Editor: “Development and validation of equations for conversion from DAS28ESR and DAS28CRP to the SDAI in patients with rheumatoid arthritis”
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 6, 2024 Category: Rheumatology Source Type: research
Non-thyroidal disease syndrome in patients with systemic lupus erythematosus: relation to disease inflammatory activity
ConclusionsInflammatory activity in SLE patients is associated with the development of NTIS.Key Points•Inflammatory activity indexes such as SLEDAI, SII, and ESR are independent risk factors for NTIS in SLE patients. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 5, 2024 Category: Rheumatology Source Type: research
Functional capacity, physical activity, and arterial stiffness in patients with systemic sclerosis
ConclusionThe present study indicates that functional capacity and self-reported physical activity are independently associated with arterial stiffness in patients with SSc. Exercise interventions targeted to increase functional capacity and physical activity may help to regulate arterial stiffness in patients with SSc.Key Points•Arterial stiffness is an independent predictor of cardiovascular risk.•SSc patients exhibit decreased exercise capacity and functional capacity.•The association of functional capacity and physical activity with arterial stiffness in patients with SSc is unknown.•Functional capacity and sel...
Source: Clinical Rheumatology - April 4, 2024 Category: Rheumatology Source Type: research
