Fluid balance during acute phase extracorporeal cardiopulmonary resuscitation and outcomes in OHCA patients: a retrospective multicenter cohort study
ConclusionsExcessive positive fluid balance in the first day following ICU admission was associated with in-hospital mortality, unfavorable outcome, AKI, and RRT in ECPR patients. Further investigation is warranted.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 18, 2024 Category: Cardiology Source Type: research
Genetic associations of cardiovascular risk genes in European patients with coronary artery spasm
ConclusionsIn summary, we suggestEDN1 as potential genetic risk loci for patients with diffuse epicardial CAS, and European ancestry. Plasma ET-1 levels may serve as a potential cardiac marker.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 18, 2024 Category: Cardiology Source Type: research
Frequency, characteristics and risk assessment of pulmonary arterial hypertension with a left heart disease phenotype
ConclusionsIn real life, PAH-LHD patients are frequent, have less severe disease and are less likely treated with PAH drug combinations than no-LHD. The COMPERA 2.0 model may be more appropriate to evaluate their mortality risk during follow-up and how it is modulated by therapy. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Prevalence of elevated lipoprotein(a) in cardiac rehabilitation patients — results from a large-scale multicentre registry in Germany
ConclusionsLp(a) had been rarely assessed in acute management of aortic valve stenosis or premature myocardial infarction despite expanding scientific evidence and guideline recommendation. Given the above-average incidence of elevated Lp(a) levels, awareness for Lp(a) has to increase substantially to better identify and manage high-risk patients.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Safety and feasibility of early discharge after transcatheter aortic valve implantation with ACURATE Neo —the POLESTAR trial
ConclusionEarly discharge after TAVI with the ACURATE valve is safe and feasible in selected patients. Rhythm monitoring and extended clinical observation protracted hospital stay.Graphical AbstractSafety and feasibility of early discharge after transcatheter aortic valve implantation with ACURATE Neo, an international multi-center, prospective observational single-arm study. OR, odds ratio (95% confidence interval); VARC, Valve Academic Research Consortium (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Prognostic impact of prior LVEF in patients with heart failure with mildly reduced ejection fraction
ConclusionThe transition from HFrEF and HFpEF towards HFmrEF is very common. However, prior LVEF was not associated with prognosis, likely due to the persistently high dynamic nature of LVEF in the follow-up period.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
The role of cardiac magnetic resonance in sports cardiology: results from a large cohort of athletes
ConclusionCMR is more efficient in identifying a pathologic cardiac substrate in athletes in case of VAs (i.e., polymorphic beats), abnormal ECG repolarisation (negative T-waves in inferolateral leads), and borderline echocardiographic findings (LV hypertrophy, mildly depressed LV function). On the other hand, CMR is associated with a large proportion of negative results. Therefore, a careful clinical selection is needed to indicate CMR in athletes appropriately.Graphical AbstractClinical indications for CMR and positive CMR findings.The left panel shows clinical indications for CMR in our athletic cohort and the percentag...
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Mortality and rehospitalization in patients with pre-existing implantable pacemakers undergoing catheter ablation are related to increased comorbidity burden —data from the German Ablation Registry
ConclusionPatients with pacemaker systems undergoing catheter ablation of atrial fibrillation or atrial flutter demonstrate an increased risk of death, cardiovascular events, and re-hospitalization. This observation can be largely attributed to an older patient population and an increased rate of comorbidities. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Prevalence of elevated lipoprotein(a) in cardiac rehabilitation patients — results from a large-scale multicentre registry in Germany
ConclusionsLp(a) had been rarely assessed in acute management of aortic valve stenosis or premature myocardial infarction despite expanding scientific evidence and guideline recommendation. Given the above-average incidence of elevated Lp(a) levels, awareness for Lp(a) has to increase substantially to better identify and manage high-risk patients.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Safety and feasibility of early discharge after transcatheter aortic valve implantation with ACURATE Neo —the POLESTAR trial
ConclusionEarly discharge after TAVI with the ACURATE valve is safe and feasible in selected patients. Rhythm monitoring and extended clinical observation protracted hospital stay.Graphical AbstractSafety and feasibility of early discharge after transcatheter aortic valve implantation with ACURATE Neo, an international multi-center, prospective observational single-arm study. OR, odds ratio (95% confidence interval); VARC, Valve Academic Research Consortium (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Prognostic impact of prior LVEF in patients with heart failure with mildly reduced ejection fraction
ConclusionThe transition from HFrEF and HFpEF towards HFmrEF is very common. However, prior LVEF was not associated with prognosis, likely due to the persistently high dynamic nature of LVEF in the follow-up period.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
The role of cardiac magnetic resonance in sports cardiology: results from a large cohort of athletes
ConclusionCMR is more efficient in identifying a pathologic cardiac substrate in athletes in case of VAs (i.e., polymorphic beats), abnormal ECG repolarisation (negative T-waves in inferolateral leads), and borderline echocardiographic findings (LV hypertrophy, mildly depressed LV function). On the other hand, CMR is associated with a large proportion of negative results. Therefore, a careful clinical selection is needed to indicate CMR in athletes appropriately.Graphical AbstractClinical indications for CMR and positive CMR findings.The left panel shows clinical indications for CMR in our athletic cohort and the percentag...
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Mortality and rehospitalization in patients with pre-existing implantable pacemakers undergoing catheter ablation are related to increased comorbidity burden —data from the German Ablation Registry
ConclusionPatients with pacemaker systems undergoing catheter ablation of atrial fibrillation or atrial flutter demonstrate an increased risk of death, cardiovascular events, and re-hospitalization. This observation can be largely attributed to an older patient population and an increased rate of comorbidities. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment
AbstractThe aetiology of heart failure with preserved ejection fraction (HFpEF) is heterogenous and overlaps with that of several comorbidities like atrial fibrillation, diabetes mellitus, chronic kidney disease, valvular heart disease, iron deficiency, or sarcopenia. The diagnosis of HFpEF involves evaluating cardiac dysfunction through imaging techniques and assessing increased left ventricular filling pressure, which can be measured directly or estimated through various proxies including natriuretic peptides. To better narrow down the differential diagnosis of HFpEF, European and American heart failure guidelines advoca...
Source: Clinical Research in Cardiology - April 11, 2024 Category: Cardiology Source Type: research
