Management of advanced prostate cancer in the Asia-Pacific region: Summary of the Asia-Pacific Advanced Prostate Cancer Consensus Conference 2023
CONCLUSION: The use of next-generation imaging, genetic testing, and new treatment combinations is increasing the complexity and duration of prostate cancer management. Familiarity with new diagnostic and treatment options is growing in the APAC region. Insights highlight the continued importance of a multidisciplinary approach that includes nuclear medicine, genetic counseling, and quality-of-life expertise. The APAC APCCC meeting provides an important opportunity to share practice and identify APAC-specific issues and considerations in areas of low evidence where clinical experience is growing.PMID:38628049 | DOI:10.1111...
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Edmund Chiong Declan G Murphy Nicholas Buchan Kenneth Chen Sarah S Chen Melvin L K Chua Agus Rizal Hamid Ravindran Kanesvaran Makarand Khochikar Jason Letran Bannakij Lojanapiwat Indranil Mallik Chee Fai Ng Teng Aik Ong Darren M C Poon Yeong-Shiau Pu Marn Source Type: research
A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
CONCLUSION: The safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer.PMID:38630382 | DOI:10.1007/s10147-024-02517-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Katsumasa Nakamura Keiji Nihei Yoshihiro Saito Naoto Shikama Shin-Ei Noda Ryusuke Hara Toshiyuki Imagumbai Takashi Mizowaki Takeshi Akiba Etsuo Kunieda Masanori Someya Saiji Ohga Jiro Kawamori Takuyo Kozuka Yosuke Ota Koji Inaba Takeshi Kodaira Yoshiyuki Source Type: research
The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression
J Clin Invest. 2024 Apr 16:e170809. doi: 10.1172/JCI170809. Online ahead of print.ABSTRACTJust as the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the prostate and is thought to influence prostate cancer (PCa) biology. Yet, the incomplete understanding of ERα functions in PCa hinders our ability to fully comprehend its clinical relevance and restricts the repurposing of estrogen-targeted therapies for the treatment of this disease. Using two human PCa tissue microarray cohorts, we first demonstrated that nuclear ERα expression was heterogeneous among patients, being only detected in half of tum...
Source: Clinical Prostate Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Camille Lafront Lucas Germain Gabriel H Campolina-Silva Cindy Weidmann Line Berthiaume H élène Hovington Herv é Brisson Cynthia Jobin Lilianne Fr égeau-Proulx Raul Cotau Kevin Gonthier Aur élie Lacouture Patrick Caron Claire M énard Chantal Atallah Source Type: research
Erratum: Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study
J Clin Oncol. 2024 Apr 16:JCO2400454. doi: 10.1200/JCO.24.00454. Online ahead of print.NO ABSTRACTPMID:38626362 | DOI:10.1200/JCO.24.00454 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 16, 2024 Category: Cancer & Oncology Source Type: research
The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression
J Clin Invest. 2024 Apr 16:e170809. doi: 10.1172/JCI170809. Online ahead of print.ABSTRACTJust as the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the prostate and is thought to influence prostate cancer (PCa) biology. Yet, the incomplete understanding of ERα functions in PCa hinders our ability to fully comprehend its clinical relevance and restricts the repurposing of estrogen-targeted therapies for the treatment of this disease. Using two human PCa tissue microarray cohorts, we first demonstrated that nuclear ERα expression was heterogeneous among patients, being only detected in half of tum...
Source: Clinical Prostate Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Camille Lafront Lucas Germain Gabriel H Campolina-Silva Cindy Weidmann Line Berthiaume H élène Hovington Herv é Brisson Cynthia Jobin Lilianne Fr égeau-Proulx Raul Cotau Kevin Gonthier Aur élie Lacouture Patrick Caron Claire M énard Chantal Atallah Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
CONCLUSIONS: Our data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation.PMID:38615286 | DOI:10.1007/s10147-024-02518-y (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2024 Category: Cancer & Oncology Authors: Tetsuya Ito Tatsuro Yamaguchi Kensuke Kumamoto Okihide Suzuki Noriyasu Chika Satoru Kawakami Tomonori Nagai Tsukasa Igawa Kenji Fujiyoshi Yoshito Akagi Tomio Arai Kiwamu Akagi Hidetaka Eguchi Yasushi Okazaki Hideyuki Ishida Source Type: research
Biological Therapy for Psoriasis in Cancer Patients: An 8-Year Retrospective Real-Life Study
Conclusions: Our experience supports the effectiveness and safety of biological therapy for psoriasis in patients with a history of cancer or recent onset neoplasia.PMID:38610706 | PMC:PMC11012886 | DOI:10.3390/jcm13071940 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Teresa Battista Lucia Gallo Fabrizio Martora Davide Fattore Luca Potestio Sara Cacciapuoti Massimiliano Scalvenzi Matteo Megna Source Type: research
Cancer risk and male Infertility: Unravelling predictive biomarkers and prognostic indicators
Clin Chim Acta. 2024 Apr 11:119670. doi: 10.1016/j.cca.2024.119670. Online ahead of print.ABSTRACTIn recent years, there has been a global increase in cases of male infertility. There are about 30 million cases of male infertility worldwide and male reproductive health is showing rapid decline in last few decades. It is now recognized as a potential risk factor for developing certain types of cancer, particularly genitourinary malignancies like testicular and prostate cancer. Male infertility is considered a potential indicator of overall health and an early biomarker for cancer. Cases of unexplained male factor infertilit...
Source: Clinical Prostate Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Prabhakar Tiwari Anjali Yadav Meenakshi Kaushik Rima Dada Source Type: research
Biological Therapy for Psoriasis in Cancer Patients: An 8-Year Retrospective Real-Life Study
Conclusions: Our experience supports the effectiveness and safety of biological therapy for psoriasis in patients with a history of cancer or recent onset neoplasia.PMID:38610706 | DOI:10.3390/jcm13071940 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Teresa Battista Lucia Gallo Fabrizio Martora Davide Fattore Luca Potestio Sara Cacciapuoti Massimiliano Scalvenzi Matteo Megna Source Type: research
Unmet supportive care needs among cancer patients: exploring cancer entity-specific needs and associated factors
CONCLUSION: The high prevalence of patients feeling inadequately informed about their disease and care aspects, particularly among those with functional impairments, reflects a key challenge in the healthcare system. Specific interventions and improvements in patient-doctor communication are essential to address cancer entity-specific care needs.PMID:38607426 | DOI:10.1007/s00432-024-05715-4 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Franziska Springer Anja Mehnert-Theuerkauf Claudia Gebhardt Jens-Uwe Stolzenburg Susanne Briest Source Type: research
Detection of the Highest-Grade Lesion in Multifocal Discordant Prostate Cancer by Multiparametric Magnetic Resonance Imaging
CONCLUSION: We found that mpMRI detectability of the highest-grade tumor in discordant cases was inferior to that of the largest tumor with low malignant potential. Our results suggest that the risk of high-grade tumors which determine patient prognosis being overlooked.PMID:38608334 | DOI:10.1016/j.clgc.2024.102084 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Kazuhiro Matsumoto Hirotaka Akita Akinori Hashiguchi Toshikazu Takeda Takeo Kosaka Keishiro Fukumoto Yota Yasumizu Nobuyuki Tanaka Shinya Morita Ryuichi Mizuno Hiroshi Asanuma Mototsugu Oya Masahiro Jinzaki Source Type: research
Explainable and visualizable machine learning models to predict biochemical recurrence of prostate cancer
CONCLUSIONS: Our score system provide reference for the identification for BCR, and the crafting of a framework for making therapeutic decisions for PCa on a personalized basis.PMID:38602643 | DOI:10.1007/s12094-024-03480-x (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Wenhao Lu Lin Zhao Shenfan Wang Huiyong Zhang Kangxian Jiang Jin Ji Shaohua Chen Chengbang Wang Chunmeng Wei Rongbin Zhou Zuheng Wang Xiao Li Fubo Wang Xuedong Wei Wenlei Hou Source Type: research
Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study
CONCLUSIONS: Screening activities should be revised and the guidelines on diabetes should be complemented with recommendations on cancer prevention also considering that the cancer incidence is highest around the time of the diagnosis of diabetes. For prostate cancer, our results contradict many previous studies, and further research is recommended to clarify this.PMID:38604444 | DOI:10.1016/j.diabres.2024.111665 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Hel éna Safadi Ágnes Balogh Judit L ám Attila Nagy Éva Belicza Source Type: research
Explainable and visualizable machine learning models to predict biochemical recurrence of prostate cancer
CONCLUSIONS: Our score system provide reference for the identification for BCR, and the crafting of a framework for making therapeutic decisions for PCa on a personalized basis.PMID:38602643 | DOI:10.1007/s12094-024-03480-x (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Wenhao Lu Lin Zhao Shenfan Wang Huiyong Zhang Kangxian Jiang Jin Ji Shaohua Chen Chengbang Wang Chunmeng Wei Rongbin Zhou Zuheng Wang Xiao Li Fubo Wang Xuedong Wei Wenlei Hou Source Type: research
Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study
CONCLUSIONS: Screening activities should be revised and the guidelines on diabetes should be complemented with recommendations on cancer prevention also considering that the cancer incidence is highest around the time of the diagnosis of diabetes. For prostate cancer, our results contradict many previous studies, and further research is recommended to clarify this.PMID:38604444 | DOI:10.1016/j.diabres.2024.111665 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Hel éna Safadi Ágnes Balogh Judit L ám Attila Nagy Éva Belicza Source Type: research
