Positive influence of partial resection on overall survival of patients with overlapping glioblastomas
Overlapping glioblastomas (OG) (former gliomatosis cerebri, GC) [12,13] is known to be a rare, highly aggressive tumor entity. According to the classification of the WHO 2007 [12]. at least three brain lobes had to be involved to fulfill the criteria of gliomatosis cerebri (GC). Brainstem and basal ganglia are taken as individual lobes according to that classification. GC can either occur as “primary” GC, or “secondary” GC as progression of a glioma. In the new WHO classification gliomatsis cerebri is no longer an own entity but refers to an unusual growth pattern, therefore in this study named overlapping glioblas...
Source: Clinical Neurology and Neurosurgery - June 28, 2017 Category: Neurosurgery Authors: Johanna Quick-Weller, Stephanie Tritt, Peter Baumgarten, J ürgen Konczalla, Sepide Kashefiolasl, Anika Noack, Julia Tichy, Volker Seifert, Gerhard Marquardt Source Type: research

Impacts of EGFR mutation and EGFR-TKIs on incidence of brain metastases in advanced non-squamous NSCLC
Lung cancer remains the leading cause of cancer-related death among males and the second leading cause of cancer-related death among females in developing countries [1]. Brain is a frequent site of progression in NSCLC, affecting 20% − 40% of patients [2,3]. Adenocarcinoma is more aggressive, and is associated with higher incidence of brain metastases than other subtypes of NSCLC [4]. When brain metastases occur, the survival is generally depressing, with an OS of about 3-6 months [5–7]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 28, 2017 Category: Neurosurgery Authors: Bao-Xiao Wang, Wei Ou, Xiao-Yong Mao, Zui Liu, Hui-Qi Wu, Si-Yu Wang Source Type: research

Acceleration of blood flow as an indicator of improved hemodynamics after indirect bypass surgery in Moyamoya disease
Moyamoya disease is characterized by a steno-occlusive lesion in the distal internal carotid artery, with development of a range of collateral networks. Long-term hemodynamic overstress in Moyamoya disease can induce pathological changes in the dilated collateral vessels, including the lenticulostriate arteries, choroidal arteries, and other basal vessels [1 –3]. The development of collateral vessels can increase the risk of rupture, which leads to hemorrhagic stroke. This hemodynamic stress is relieved by bypass flow surgery, which reduces the burden on the Moyamoya vessels to maintain cerebral blood flow. (Source: Clin...
Source: Clinical Neurology and Neurosurgery - June 26, 2017 Category: Neurosurgery Authors: Sayaka Ogawa, Toshiyasu Ogata, Hirofumi Shimada, Hiroshi Abe, Toshiro Katsuta, Kenji Fukuda, Tooru Inoue Source Type: research

Pipeline Embolization of Posterior Communicating Artery Aneurysms Associated with a Fetal Origin Posterior Cerebral Artery
The Pipeline Embolization Device (PED; Medtronic Neurovascular, Irvine, CA) received FDA approval in 2011 for the treatment of aneurysms larger than 10mm in size with necks larger than 4mm located from the petrous to superior hypophyseal segments of the internal carotid artery (ICA). Although successful off-label use of the device to treat ICA aneurysms smaller than 10mm in size has been widely reported [1 –7], Pipeline embolization of posterior communicating artery (PComA) aneurysms associated with a hypoplastic ipsilateral P1 segment, or fetal origin posterior cerebral artery (PCA), raises two important concerns. (Sour...
Source: Clinical Neurology and Neurosurgery - June 26, 2017 Category: Neurosurgery Authors: Adam N. Wallace, Yasha Kayan, Matthew J. Austin, Josser E. Delgado Almandoz, Mudassar Kamran, DeWitte T. Cross, Christopher J. Moran, Joshua W. Osbun, Akash P. Kansagra Tags: Full Length Article Source Type: research

Enterprise stent in recanalizing non-acute atherosclerotic intracranial internal carotid artery occlusion
Non-acute atherosclerotic intracranial internal carotid artery occlusion (IICAO) forms on the basis of vascular stenosis and is associated with serious clinical symptoms and poor prognosis. Despite conservative therapies including antiplatelet aggregation, patients still suffer from repeated ischemic events due to the lack of compensatory collateral circulation. Safe and efficient therapeutic approaches have been developed, such as percutaneous vascular recanalization with a stent. This stent recanalization has been applied to intracranial occlusions of the basilar artery and vertebrobasilar arteries, but with a lower succ...
Source: Clinical Neurology and Neurosurgery - June 26, 2017 Category: Neurosurgery Authors: Xiaofei Wang, Zhigang Wang, Yong Ji, Xuan Ding, Yizheng Zang, Chengwei Wang Source Type: research

Monthly methylprednisolone in combination with interferon beta or glatiramer acetate for relapsing-remitting multiple sclerosis: a multicentre, single-blind, prospective trial
Multiple sclerosis (MS) is a chronic immune-mediate disease involving both genetic and environmental determinants. It is usually clinically characterized by repeated subacute relapses followed by remissions, known as relapsing –remitting MS (RRMS). No curative treatment for MS is available, and therapeutic strategies are aimed at treating relapses, preventing new relapses and avoiding progression of disability [1]. Treatment of relapses has been based on the use of corticosteroids since the early 1950s. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 26, 2017 Category: Neurosurgery Authors: Serkan Ozakbas, Bilge Piri Cinar, Gorkem Kosehasano ğullari, Turhan Kahraman, Didem Oz, Behice Bircan Kursun Source Type: research

123I-Meta-iodobenzylguanidine (MIBG) myocardium scintigraphy in patients showing scans without evidence of dopaminergic deficits (SWEDDs)
Dopamine transporter single-photon emission computed tomography (DAT-SPECT) with 123I-labeled 2 β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) is used to evaluate patients who are clinically presumed to have Parkinson’s disease (PD), because it can identify nigrostriatal degeneration with high sensitivity and specificity [1]. It is improbable that DAT-SPECT wo uld show normal findings in early PD, because 50% or more of striatal neurons have been lost by the time clinical symptoms of PD become manifest [2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 26, 2017 Category: Neurosurgery Authors: Fumihito Yoshii, Yusuke Moriya, Tomohide Ohnuki, Masafuchi Ryo, Wakoh Takahashi, Saori Kohara, Jun Hashimoto Source Type: research

Posterior Communicating Artery Aneurysms Causing Facial Pain: A Comprehensive Review
Posterior communicating artery aneurysms (PComAAs) are the second most common cerebral aneurysms overall (25% of all intracranial aneurysms) [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 22, 2017 Category: Neurosurgery Authors: Javier Ros de San Pedro Tags: Review Article Source Type: research

Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant
Primary central nervous system vasculitis (PCNSV), also known as isolated angiitis of the CNS, is a very rare disease. Its diagnosis represents a challenge for clinicians [1]. The infrequency of the disease and the difficulties in diagnosing this condition correctly are the main reasons for the lack of a reliable registry and epidemiologic data [2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 22, 2017 Category: Neurosurgery Authors: Markus Kraemer, Jana Becker, Peter A. Horn, Jan Claudius Schwitalla, Kathy Keyvani, Imke Metz, Christiane Wegner, Wolfgang Br ück, Marc Schlamann, Falko M. Heinemann, Peter Berlit Source Type: research

Fosphenytoin-Induced Purple Glove Syndrome: A Case Report
Purple glove syndrome (PGS) is an atypical adverse drug reaction that can occur after the administration of intravenous phenytoin. Although definitions of PGS vary, it has been loosely defined as signs and symptoms of progressive edema, discoloration, and pain that occurs following administration of intravenous phenytoin [1]. The characteristics of this syndrome occur in three different stages: appearance, progression, and resolution of symptoms. These characteristics usually occur in the upper extremity, distal to the intravenous access site. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 19, 2017 Category: Neurosurgery Authors: Joseph W. Newman, Joseph R. Blunck, Ronald K. Fields, John E. Croom Tags: Case Report Source Type: research

Effects of dexmedetomidine on CD42a+/CD14+, HLADR+/CD14+ and inflammatory cytokine levels in patients undergoing multilevel spinal fusion
Multi segmental spinal fusion is characterized by severe trauma and stress that frequently affect middle aged and elderly people. Surgery as well as anesthesia has been shown to modulate the stress response which involves both the endocrine as well as immune system [1]. Meanwhile, excessive inflammatory reactions lead to an imbalance of body function, causing serious adverse reactions. Therefore, excessive inflammatory response in the perioperative period is an important factor influencing the prognosis of patients. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 15, 2017 Category: Neurosurgery Authors: Hongmei Zhou, Jian Lu, Yingyan Shen, Shuai Kang, Youming Zong Source Type: research

Premotor symptoms and the risk of Parkinson ’s disease: a case-control study in Mexican population.
Our understanding of Parkinson ’s disease (PD) has evolved from a neurological disease into a multi-system disorder, characterized by motor and non-motor features (NMS). Some of these non-motor symptoms include hyposmia/anosmia, neuropsychiatric disorders, gastrointestinal problems, sleep disorders and autonomic dysfunction [1] . Most of these NMS tend to appear before the motor symptoms (MS) of PD. The latter may be partially explained by the deposition of alpha-synuclein aggregates in non-nigral brainstem nuclei (serotoninergic, noradrenergic and cholinergic transmission pathways) and ventro-caudal progression suggeste...
Source: Clinical Neurology and Neurosurgery - June 14, 2017 Category: Neurosurgery Authors: Mayela Rodr íguez-Violante, Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Ned Merari Davila-Avila, Edith Carreón-Bautista, Ingrid Estrada-Bellmann, Guillermo Parra-López, Diego Cruz-Fino, Francisco Pascasio-Astudillo Source Type: research

Deep brain stimulation of subthalamic nucleus helps in improving late phase motor planning in Parkinson ’s disease
Bereitschaftspotentials (BP) are negative cortical evoked potentials that begin 1000 –1500 milliseconds (ms) prior to the onset of a self-paced movement [1]; they represent the cortical activity before the actual onset of the movement. Recording scalp BP has helped to study motor planning in health as well as in disease [2,3]. Two major components of BP can be distinguished associ ated with voluntary movement viz early and late BP. The early component is bilaterally symmetrical across the scalp with maximal amplitude recorded at the vertex and with a principal source in the bilateral supplementary motor area [4,5]. (Sour...
Source: Clinical Neurology and Neurosurgery - June 14, 2017 Category: Neurosurgery Authors: Patil Ashlesh, Sood Sanjay Kumar, Kochhar Kanwal Preet, Goyal Vinay Source Type: research

Serum lipoprotein-associated phospholipase A2 predicts the formation of carotid artery plaque and its vulnerability in anterior circulation cerebral infarction
Stroke is the leading cause of adult death and disability in China. Vulnerability of the atherosclerotic plaque is one of the pathological processes of ischemic stroke [1,2]. Recent researches demonstrate that inflammation plays an important role in atherosclerosis [3 –5] and inflammatory markers reveal the subclinical changes of stroke [6,7]. Evidence has been provided that high-sensitive C-creative protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) show prognostic value in stroke and coronary heart disease [8–12]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 14, 2017 Category: Neurosurgery Authors: Yuping Yang, Tao Xue, Juehua Zhu, Jiayi Xu, Xiaowei Hu, Penghao Wang, Tao Kong, Yan Yan, Lihui Yang, Shouru Xue Source Type: research

Corrigendum to “Optic nerve sheath fenestration for idiopathic intracranial hypertension: A seven year review of visual outcomes in a tertiary centre” [Clin. Neurol. Neurosurg. 137 (October) (2015) 94–101]
The authors regret that unfortunately due to an error in extracting data from our theatre operating database, 1 male patient was unfortunately missed in our collated database. In addition, this patient was further missed on our manual review of the collated study data because some authors believed it to be a strictly 7 year study starting in 2004 to 2010 with a minimum follow up of 6 months within this period. The actual study accrued data for approximately 7.5 years from the end of May 2004 to the first week in December 2011. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - June 13, 2017 Category: Neurosurgery Authors: E.E. Obi, B.K. Lakhani, J. Burns, R. Sampath Tags: Corrigendum Source Type: research