Additional Genetic Variants in Inherited Dilated Cardiomyopathy: Just Another Brick in the Wall? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 16, 2018 Category: Cardiology Authors: van Tintelen, J. P., Pinto, Y. M. Tags: Genetics, Cardiomyopathy, Heart Failure Editorial Source Type: research

Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees [Original Articles]
Conclusions: Our data support DCM as a genetically heterogeneous disease with, at times, multigene causation. Although the frequency of DCM resulting from multigenic cause is uncertain, our data suggest it may be higher than previously anticipated. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 16, 2018 Category: Cardiology Authors: Cowan, J. R., Kinnamon, D. D., Morales, A., Salyer, L., Nickerson, D. A., Hershberger, R. E. Tags: Genetics, Cardiomyopathy, Heart Failure Original Articles Source Type: research

Rare and Low-Frequency Variant of ARHGEF17 Is Associated With Intracranial Aneurysms [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: He, L., Pierce, R. W., Min, W. Tags: Genetic, Association Studies, Cerebral Aneurysm Editorial Source Type: research

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Status and Protection Against Ischemic Stroke: PheWAS, TreWAS, and More [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Sullivan, D., Bonnitcha, P., Spinks, C., Keech, T. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Editorial Source Type: research

Managing Secondary Genomic Findings Associated With Arrhythmogenic Right Ventricular Cardiomyopathy: Case Studies and Proposal for Clinical Surveillance [Perspective]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Haggerty, C. M., Murray, B., Tichnell, C., Judge, D. P., Tandri, H., Schwartz, M., Sturm, A. C., Matsumura, M. E., Murray, M. F., Calkins, H., Fornwalt, B. K., James, C. A. Tags: Arrhythmias, Risk Factors, Genetics, Cardiomyopathy Perspective Source Type: research

Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke [Original Articles]
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research

Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms [Original Articles]
Conclusions: Our results provide compelling evidence that ARHGEF17 is a risk gene for IA. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Yang, X., Li, J., Fang, Y., Zhang, Z., Jin, D., Chen, X., Zhao, Y., Li, M., Huan, L., Kent, T. A., Dong, J.-F., Jiang, R., Yang, S., Jin, L., Zhang, J., Zhong, T. P., Yu, F. Tags: Computational Biology, Basic Science Research, Genetics, Functional Genomics, Cerebral Aneurysm Original Articles Source Type: research

Response by Lee and Stouffer to Letter Regarding Article, "Clinical Outcomes and Sustainability of Using CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention" [Response to Letter to the Editor]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 9, 2018 Category: Cardiology Authors: Lee, C. R., Stouffer, G. A. Tags: Genetics, Pharmacology, Acute Coronary Syndromes, Atherosclerosis Response to Letter to the Editor Source Type: research

Letter by Aw et al Regarding Article, "Clinical Outcomes and Sustainability of Using CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention" [Letter to the Editor]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 9, 2018 Category: Cardiology Authors: Aw, J. W. X., Tan, D. S.-Y., Goh, L. L. Tags: Genetics, Percutaneous Coronary Intervention, Acute Coronary Syndromes Letter to the Editor Source Type: research

HCN4 Gene Polymorphisms and Tachycardia-Induced Cardiomyopathy: True or Spurious Association? [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 9, 2018 Category: Cardiology Authors: Tsai, C.-T. Tags: Basic Science Research Editorial Source Type: research

Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans [Original Articles]
Conclusions: Our targeted resequencing of individuals at the HDL-C phenotypic extremes offers a novel, efficient, and cost-effective approach for identifying rare coding and noncoding variation differences in extreme phenotypes and supports the rationale for applying this methodology to uncover rare variation—particularly noncoding variation—underlying myriad complex traits. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 9, 2018 Category: Cardiology Authors: Khetarpal, S. A., Babb, P. L., Zhao, W., Hancock-Cerutti, W. F., Brown, C. D., Rader, D. J., Voight, B. F. Tags: Basic Science Research, Gene Expression & Regulation, Genetic, Association Studies, Genetics, Functional Genomics Original Articles Source Type: research

HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation [Original Articles]
Conclusions: The HCN4 gene single-nucleotide polymorphism rs7164883 may be a new genetic marker for TIC in patients with AF. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - July 9, 2018 Category: Cardiology Authors: Nakano, Y., Ochi, H., Sairaku, A., Onohara, Y., Tokuyama, T., Motoda, C., Matsumura, H., Tomomori, S., Amioka, M., Hironobe, N., Ohkubo, Y., Okamura, S., Makita, N., Yoshida, Y., Chayama, K., Kihara, Y. Tags: Atrial Fibrillation, Genetics, Cardiomyopathy Original Articles Source Type: research

Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis [Review]
The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with age, with at least 1 in 10 adults older than 70 years affected. Carriers of clonal hematopoiesis have been shown to be not only at heightened risk for hematologic malignancy but also at increased risk for atherosclerotic cardiovascular disease. Here, we review the prior literature of clonal selection and expansion of hematopoiet...
Source: Circulation: Cardiovascular Genetics - July 9, 2018 Category: Cardiology Authors: Natarajan, P., Jaiswal, S., Kathiresan, S. Tags: Inflammation, Aging, Cardiovascular Disease, Genetics, Atherosclerosis Review Source Type: research

Branched-Chain Amino Acids: The Metabolic Link Between Type 2 Diabetes Mellitus and Cardiovascular Disease? [Correction]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 14, 2018 Category: Cardiology Tags: Correction Source Type: research

APOL1 Sends Its REGARDS to Cardiovascular Disease [Editorial]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - June 13, 2018 Category: Cardiology Authors: Waitzman, J. S., Wilkins, J. T., Lin, J. Tags: Cardiovascular Disease, Genetic, Association Studies, Ischemic Stroke, Atherosclerosis, Coronary Artery Disease Editorial Source Type: research