Synergistic Inhibitions of Gram-negative Bacteria by Combination Treatment with Ciprofloxacin and a Novel Glucolipid
Chem Biodivers. 2024 Apr 17:e202400578. doi: 10.1002/cbdv.202400578. Online ahead of print.ABSTRACTPsychrophilic fungus Pseudogymnoascus sp. OUCMDZ-4032 derived from Antarctica was cultivated under 16 ℃ to produce a new glucolipid compound (1). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization, and 13C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against bacteria, it can reduce the minimum inhibitory concentration (MIC) of ciprofloxacin against Gram-negative bacteria Pseudomonas aeru...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Liyuan Yang Qingqing Zhang Deng Yu Weiming Zhu Yi Wang Source Type: research
Flavonoids from the Aerial Parts of Sophora tonkinensis and Their Potential Anti-inflammatory Activities
Chem Biodivers. 2024 Apr 18:e202400399. doi: 10.1002/cbdv.202400399. Online ahead of print.ABSTRACTFour undescribed prenylated flavonoids, sophoratones A-D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effect...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Qing-Qing Yang Yan-Fei Yang Xuan-Qin Chen Rong-Tao Li Zhi-Jun Zhang Source Type: research
Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti-monoamine Oxidase Activity
Chem Biodivers. 2024 Apr 18:e202400524. doi: 10.1002/cbdv.202400524. Online ahead of print.ABSTRACTBaihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti-monoamine ox...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Chengcheng Hui Shuaibo He Mengshan Ji Yuhang Zhang Haibo Wang Xiaowei Wang Tao Guo Source Type: research
Phytochemical Composition, Antioxidant and Antimicrobial Activity of Three Monarda Species: M. bradburiana L. C. Beck, M. × media Willd., and M. punctata L
This study aimed to evaluate the differences in chemical characteristics and biological activity among different organs of plants representing three underinvestigated species of this genus: Monarda bradburiana L. C. Beck, Monarda × media Willd., and Monarda punctata L. The content of phenolic compounds and the antioxidant activity of leaves, stems, and inflorescences were determined. Essential oil (EO) content, composition, and antimicrobial activity were also examined. M. punctata leaves and inflorescences had the highest EO content (4.43% and 5.59%, respectively), with carvacrol as a dominant constituent. Leaf EO was al...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Łukasz Gontar Anna Geszprych And żelika Drutowska Ewa Osi ńska Source Type: research
Synthesis of some novel 1H-phenanthro [9,10-d]imidazole derivatives and their Antibacterial and Molecular docking investigation
In this study, several imidazole derivatives in one pot multicomponent reaction from various aldehydes (1(a-z)), 9,10-phenanthrenequinone, or benzyl (2), and ammonium acetate (3) were synthesized in the presence of acetic acid (AcOH) under reflux conditions at 120°C. Also, the photochromic properties of synthesized compounds were investigated in AcOH as a solvent under laboratory conditions at a temperature of 120°C. Moreover, the antibacterial and antioxidant activity of the synthesized compounds was investigated. The structure of the products was confirmed using FT-IR, UV-Vis, 1HNMR, and 13CNMR spectroscopy. The antimi...
Source: Chemistry and Biodiversity - April 18, 2024 Category: Biochemistry Authors: Nosrat O Mahmoodi Anahita Rajabi Hadiseh Yazdani Nyaki Hossein Taherpour Nahzomi Source Type: research
Further polycyclic quinones of Micromonospora sp
Chem Biodivers. 2024 Apr 16:e202301771. doi: 10.1002/cbdv.202301771. Online ahead of print.ABSTRACTThe crude acetone extract of a marine Micromonospora sp. strain associated with Eudistoma vannnamei was fractioned with hexane and ethyl acetate. The crude extract and both soluble fractions were assayed against several bacteria strains. The new polycyclic quinones 12-hydroxy-9-propyltetracene-6,1-dione (1), 5,12-dihydroxy-4-methoxy-9-propyltetracene-5,12-dione (2), and 4,6-dihydroxy-3-methoxycarbonyl- methyl-6a-(oxobutyl)-5,12-anthraquinone (3), along with the known 4,6-dihydroxy-3-methoxycarbonyl-methyl-6a-(oxo-3-methyl-but...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Otilia Deusdenia Loiola Pessoa Hozana Patricia Silva de Freitas Ces ário Francisco das Chagas Lima Pinto Kirley Marques Canuto Ediberto Rocha Silveira Diego Veras Wilke Elthon Gois Ferreira Alu ísio Marques da Fonseca Mayron Alves de Vasconcelos Edson H Source Type: research
BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity, and antimicrobial, antioxidant, and anti-inflammatory properties. This exploration could potentially uncover novel applications for this natural product, bolstering both meliponiculture practices and the preservation of native b...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Amanda Tristao Santini Rayra Annara Otac ílio Pinto Josy Goldoni Lazarini Daniel Vieira de Morais Anna Maria Alves de Piloto Fernandes Marcelo Franchin Patricia Lunardelli Negreiros de Carvalho Carolina Girotto Pressete Pedro Luiz Rosalen Severino Matias Source Type: research
Further polycyclic quinones of Micromonospora sp
Chem Biodivers. 2024 Apr 16:e202301771. doi: 10.1002/cbdv.202301771. Online ahead of print.ABSTRACTThe crude acetone extract of a marine Micromonospora sp. strain associated with Eudistoma vannnamei was fractioned with hexane and ethyl acetate. The crude extract and both soluble fractions were assayed against several bacteria strains. The new polycyclic quinones 12-hydroxy-9-propyltetracene-6,1-dione (1), 5,12-dihydroxy-4-methoxy-9-propyltetracene-5,12-dione (2), and 4,6-dihydroxy-3-methoxycarbonyl- methyl-6a-(oxobutyl)-5,12-anthraquinone (3), along with the known 4,6-dihydroxy-3-methoxycarbonyl-methyl-6a-(oxo-3-methyl-but...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Otilia Deusdenia Loiola Pessoa Hozana Patricia Silva de Freitas Ces ário Francisco das Chagas Lima Pinto Kirley Marques Canuto Ediberto Rocha Silveira Diego Veras Wilke Elthon Gois Ferreira Alu ísio Marques da Fonseca Mayron Alves de Vasconcelos Edson H Source Type: research
BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity, and antimicrobial, antioxidant, and anti-inflammatory properties. This exploration could potentially uncover novel applications for this natural product, bolstering both meliponiculture practices and the preservation of native b...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Amanda Tristao Santini Rayra Annara Otac ílio Pinto Josy Goldoni Lazarini Daniel Vieira de Morais Anna Maria Alves de Piloto Fernandes Marcelo Franchin Patricia Lunardelli Negreiros de Carvalho Carolina Girotto Pressete Pedro Luiz Rosalen Severino Matias Source Type: research
Computational Exploration of Naturally Occurring Flavonoids as TGF- β Inhibitors in Breast Cancer: Insights from Docking and Molecular Dynamics Simulations and In-vitro Cytotoxicity Study
This study explores naturally occurring flavonoids' interactions with TGF-β. Using molecular docking against the protein's crystal structure (PDB Id: 1PY5), Gossypin showed the highest docking score and underwent molecular dynamics simulation, revealing complex flexibility and explaining how flavonoids impede TGF-β signaling in breast cancer. ADMET predictions adhered to Lipinski's rule of Five. Insights into flavonoid-TGF-β binding offer a novel angle for breast cancer treatment. Flavonoids having a good docking score like gossypin, morin, luteolin and taxifolin shown potent cytotoxic effect on breast cancer cell line,...
Source: Chemistry and Biodiversity - April 16, 2024 Category: Biochemistry Authors: Umang Shah Niyati Patel Mehul Patel Shishir Rohit Nilay Solanki Ashish Patel Swayamprakash Patel Vishwa Patel Rajvi Patel Rahul D Jawarkar Source Type: research
Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia umbellata
Chem Biodivers. 2024 Apr 16:e202400395. doi: 10.1002/cbdv.202400395. Online ahead of print.ABSTRACTEndophytic fungi live asymptomatically inside vegetal tissues, and such uncommon habitat contributes to their exceptional chemical diversity. Isolating natural products from endophytic fungi could fail due to silent biosynthetic gene clusters under ordinary in vitro culture conditions, and co-culturing has been assayed to trigger their metabolism. We carried out single and dual cultures with 13 endophyte strains isolated from Euphorbia umbellata leaves. Multivariate statistics applied to untargeted metabolomics compared the c...
Source: Chemistry and Biodiversity - April 16, 2024 Category: Biochemistry Authors: Amanda Santos Gusm ão Jo ão Carlos Silva Conceição Stefane Moreira de Queiros Santos Cecilia Lima Sampaio Pereira Douglas Siqueira de Almeida Chaves Karen de Jesus Nic ácio Daniela Aparecida Chagas-Paula Eliane Oliveira Silva Source Type: research
Ring-contracted Artemisinin Derivatives as Novel CDK4/6 Inhibitors: Synthesis and Anti-Breast Cancer Evaluation
Chem Biodivers. 2024 Apr 15:e202400086. doi: 10.1002/cbdv.202400086. Online ahead of print.ABSTRACTThe endoperoxide group of artemisinins is a universally accepted essential group for their anti-cancer effects. In this work, a series of D-ring-contracted artemisinin derivatives were constructed by combining ring-contracted artemisinin core with the fragments of functional heterocyclic molecules or classical CDK4/6 inhibitors to identify more efficacious breast cancer treatment agents. Twenty-six novel hybridized molecules were synthesized and characterized by HRMS, IR, 1H NMR and 13C NMR data. In antiproliferative activiti...
Source: Chemistry and Biodiversity - April 15, 2024 Category: Biochemistry Authors: Junjie Zhu Yi Ai Junhui Wu Changgaung Zeng Zhen Cui Zhengping Zhang Jiayi Zhu Changqi Wang Hang Zhong Source Type: research
Unveiling The Biomedical Applications Of Novel Coumarins Isolated From Capsicum Annuum L. Seeds By A Multivariate Extraction Technique
Chem Biodivers. 2024 Apr 15:e202400581. doi: 10.1002/cbdv.202400581. Online ahead of print.ABSTRACTFor the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the cou...
Source: Chemistry and Biodiversity - April 15, 2024 Category: Biochemistry Authors: Areej Hazem Fakri Younes Yasser Fakri Mustafa Source Type: research
Ring-contracted Artemisinin Derivatives as Novel CDK4/6 Inhibitors: Synthesis and Anti-Breast Cancer Evaluation
Chem Biodivers. 2024 Apr 15:e202400086. doi: 10.1002/cbdv.202400086. Online ahead of print.ABSTRACTThe endoperoxide group of artemisinins is a universally accepted essential group for their anti-cancer effects. In this work, a series of D-ring-contracted artemisinin derivatives were constructed by combining ring-contracted artemisinin core with the fragments of functional heterocyclic molecules or classical CDK4/6 inhibitors to identify more efficacious breast cancer treatment agents. Twenty-six novel hybridized molecules were synthesized and characterized by HRMS, IR, 1H NMR and 13C NMR data. In antiproliferative activiti...
Source: Chemistry and Biodiversity - April 15, 2024 Category: Biochemistry Authors: Junjie Zhu Yi Ai Junhui Wu Changgaung Zeng Zhen Cui Zhengping Zhang Jiayi Zhu Changqi Wang Hang Zhong Source Type: research
Unveiling The Biomedical Applications Of Novel Coumarins Isolated From Capsicum Annuum L. Seeds By A Multivariate Extraction Technique
Chem Biodivers. 2024 Apr 15:e202400581. doi: 10.1002/cbdv.202400581. Online ahead of print.ABSTRACTFor the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the cou...
Source: Chemistry and Biodiversity - April 15, 2024 Category: Biochemistry Authors: Areej Hazem Fakri Younes Yasser Fakri Mustafa Source Type: research
