The activation of HAMP promotes colorectal cancer cell proliferation through zinc-mediated upregulation of SMAD4 expression
CONCLUSIONS: HAMP stands out as an independent prognostic factor in CRC, representing a potential therapeutic target. Its intricate regulation by zinc, particularly through the modulation of SMAD4, unveils a novel avenue for understanding CRC biology. This study provides valuable insights into the interplay between zinc metabolism, HAMP, and CRC, offering promising clinical indicators for CRC patients. The findings present a compelling case for further exploration and development of targeted therapeutic strategies in CRC management.PMID:38617511 | PMC:PMC11009800 | DOI:10.21037/tcr-23-1292 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Fei Pan Mengting Hu Tao Ye Jiaqi Gan Meirong Ling Mei Liu Source Type: research
< em > CLCN3 < /em > in mediating the proliferation of human ovarian cancer cells
CONCLUSIONS: CLCN3 is a possible biomarker for immune-related processes and the prognosis of cancer, and the PI3K/AKT signaling pathway may affect OC cells' ability to proliferate.PMID:38617512 | PMC:PMC11009797 | DOI:10.21037/tcr-23-1272 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Lufei Ren Yuyang Li Yifan Feng Zhe Zhang Huijun Yang Min Li Source Type: research
A four-gene signature predicts overall survival of patients with esophageal adenocarcinoma
CONCLUSIONS: The four-gene signature identified in the current study may be a potential prognostic factor for predicting OS of EAC patients.PMID:38617513 | PMC:PMC11009802 | DOI:10.21037/tcr-23-1798 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Yanmei Mao Haibo Zhang Xin He Jing Chen Lanyan Xi Yanping Chen Ying Zeng Source Type: research
Nomograms for predicting prognostic value of combined neutrophil-to-lymphocyte ratio and SCC-Ag in locally advanced cervical cancer
CONCLUSIONS: The combination of SCC-Ag and NLR could provide a better predictive prognosis than SCC-Ag or NLR alone, and nomograms based on PFS and OS can be recommended as practical models for evaluating the prognosis of LACC patients.PMID:38617514 | PMC:PMC11009798 | DOI:10.21037/tcr-23-1501 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Long Jin Fei Cao Yuan Zhang Yunzhi Dang Fei Wang Source Type: research
Low expression of < em > KLRB1 < /em > predicts poor survival outcomes and is associated with immune infiltration in breast cancer
CONCLUSIONS: This research investigated the mechanism and potential therapeutic target of the KLRB1 gene in BRCA. By analyzing the expression and function of the KLRB1 gene, the study aims to find its significant role in the onset and progression of BRCA. This research endeavors to offer novel strategies and approaches for treating BRCA.PMID:38617516 | PMC:PMC11009814 | DOI:10.21037/tcr-23-1231 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Xiao Liu Qianqian Cui Nan Qin Source Type: research
Comprehensive analysis of exosome gene LYPD3 and prognosis/immune cell infiltration in lung cancer
CONCLUSIONS: LYPD3 is involved in many BPs of LC, such as regulating immune cell infiltration and affecting prognosis. Therefore, LYPD3 may have potential value as a biomarker for prognosis and immunotherapy in LC.PMID:38617517 | PMC:PMC11009804 | DOI:10.21037/tcr-23-1557 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Tao Xin Chunlong Zheng Gui-Zhen Li Xinyao Xu Jipeng Zhang Chenghui Jia Pengyu Jing Qiang Lu Source Type: research
< em > RAC1 < /em > as a potential pan-cancer diagnostic, prognostic, and immunological biomarker
CONCLUSIONS: This extensive solid tumor analysis provides sound evidence that RAC1 can serve as both as an immunotherapy target and as a diagnostic and prognostic biomarker.PMID:38617518 | PMC:PMC11009796 | DOI:10.21037/tcr-23-2016 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Linglong Tao Xiaoyu Xu Zhengxuying Fang Petros Christopoulos Diego Cortinovis Yi Lu Source Type: research
Modeling of new markers for the diagnosis and prognosis of pancreatic cancer based on the transition from inflammation to cancer
CONCLUSIONS: The AP and CP co-related genes were significantly correlated with PAAD. TINAG, DDC, SPDEF, and APOBEC1 could serve as new PAAD predictors. The risk model developed in this study could be used to predict the prognosis of PAAD patients.PMID:38617519 | PMC:PMC11009810 | DOI:10.21037/tcr-23-1365 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Yuan Zhou Borong Huang Qinqin Zhang Yaqun Yu Juan Xiao Source Type: research
A novel PD-1/PD-L1 pathway-related seven-gene signature for the development and validation of the prognosis prediction model for breast cancer
CONCLUSIONS: PD-1/PD-L1 pathway-related subtypes of BC were identified, which were closely associated with the immune microenvironment, the ferroptosis status, and m6A in BC patients. The gene signature involved in the PD-1/PD-L1 pathway might help to make a distinction and predict prognosis in BC patients.PMID:38617520 | PMC:PMC11009795 | DOI:10.21037/tcr-23-2270 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Peng Zhang Jingjing Yang Xiaolong Zhong Heloisa Sobreiro Selistre-de-Araujo Stergios Boussios Yongneng Ma Hua Fang Source Type: research
CCND2 is a prognostic biomarker and correlates with immune infiltration in lung adenocarcinoma
CONCLUSIONS: CCND2 can be exploited as a novel prognostic biomarker involved in immune infiltration of LUAD, hence providing new preventative and therapeutic options for LUAD.PMID:38617521 | PMC:PMC11009805 | DOI:10.21037/tcr-23-1863 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Erna Jia Xianquan Shi Jinru Xue Source Type: research
Application and progress of CRISPR/Cas9 gene editing in B-cell lymphoma: a narrative review
CONCLUSIONS: CRISPR/Cas9 gene editing has great promise in the treatment of B-cell lymphoma. This article reviews some genes, signaling pathways, and cytokines related to the progression and prognosis of B-cell lymphoma to provide a strong theoretical basis.PMID:38617522 | PMC:PMC11009809 | DOI:10.21037/tcr-23-1146 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Ying Jin Haiyi Wu Jianzhao Liu William C Cho Guoqi Song Source Type: research
The prognostic biomarker TPGS2 is correlated with immune infiltrates in pan-cancer: a bioinformatics analysis
CONCLUSIONS: TPGS2 is aberrantly expressed in most cancer tissues and might be associated with immune cell infiltration in the tumor microenvironment. TPGS2 could serve not only as a biomarker for predicting clinical outcomes, but also as a promising biomarker for evaluating and developing new approaches to immunotherapy in many types of cancers, especially colon adenocarcinoma and stomach adenocarcinoma.PMID:38617524 | PMC:PMC11009813 | DOI:10.21037/tcr-23-113 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Zujun Ding Qing Ding Hang Li Source Type: research
Identification of an immune-related signature as a prognostic classifier for patients with early-stage head and neck squamous cell carcinoma
CONCLUSIONS: Our novel IRGS is a reliable and robust classifier for accurate patient stratification and prognostic evaluation. Future studies will attempt to affirm the signature's clinical application to early-stage HNSCC.PMID:38617526 | PMC:PMC11009812 | DOI:10.21037/tcr-23-1791 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Le Wang Yulin Zhang Hongmin Li Jilin Peng Changhui Gao Qiuning Yu Pei Gao Ling Li Kuisheng Chen Fanglei Ye Source Type: research
Comprehensive analysis of disulfidptosis-related lncRNAs for predicting prognosis and response of immunotherapy in pancreatic adenocarcinoma
CONCLUSIONS: In conclusion, we established a DRlncRNA index comprising of five DRlncRNAs, which may provide new insights for clinical diagnosis and precision therapy.PMID:38617527 | PMC:PMC11009799 | DOI:10.21037/tcr-23-1706 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Junheng Guo Yuyao Wang Jingyu Hou Tingshuo Zhao Zhigang Wei Source Type: research
Association of Retinal Neurovascular Impairment with Disease Severity in Patients with Major Depressive Disorder: An Optical Coherence Tomography Angiography Study
CONCLUSION: We found the retinal neurovascular impairment and its association with disease severity in MDD patients. OCTA showed promise as a potential complementary assessment tool for MDD.PMID:38617578 | PMC:PMC11015850 | DOI:10.2147/PRBM.S443146 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Yan Wang Cong Li Lei Liu Yuan Yang Xue He Gang Li Xianzhen Zheng Yun Ren Hanpeng Zhao Zhenchao Du Jianrong Jiang Yu Kuang Fujun Jia Honghua Yu Xiaohong Yang Source Type: research
