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The intersection of frailty and metabolism
Cell Metab. 2024 Apr 5:S1550-4131(24)00091-3. doi: 10.1016/j.cmet.2024.03.012. Online ahead of print.ABSTRACTOn average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how...
Source: Cell Metabolism - April 13, 2024 Category: Cytology Authors: Manish Mishra Judy Wu Alice E Kane Susan E Howlett Source Type: research

New and emerging treatments for metabolic dysfunction-associated steatohepatitis
Cell Metab. 2024 Apr 7:S1550-4131(24)00090-1. doi: 10.1016/j.cmet.2024.03.011. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH) is a leading etiology of chronic liver disease worldwide, with increasing incidence and prevalence in the setting of the obesity epidemic. MASH is also a leading indication for liver transplantation, given its associated risk of progression to end-stage liver disease. A key challenge in managing MASH is the lack of approved pharmacotherapy. In its absence, lifestyle interventions with a focus on healthy nutrition and regular physical activity have been the corn...
Source: Cell Metabolism - April 12, 2024 Category: Cytology Authors: Monica A Tincopa Quentin M Anstee Rohit Loomba Source Type: research

ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes
Cell Metab. 2024 Apr 10:S1550-4131(24)00122-0. doi: 10.1016/j.cmet.2024.04.002. Online ahead of print.NO ABSTRACTPMID:38604169 | DOI:10.1016/j.cmet.2024.04.002 (Source: Cell Metabolism)
Source: Cell Metabolism - April 11, 2024 Category: Cytology Authors: Zhen Lu Noreen McBrearty Jinyun Chen Vivek S Tomar Hongru Zhang Gianluca De Rosa Aiwen Tan Aalim M Weljie Daniel P Beiting Zhen Miao Subin S George Allison Berger Gurpanna Saggu J Alan Diehl Constantinos Koumenis Serge Y Fuchs Source Type: research

Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
We present here a machine learning program senescent cell identification (SenCID), which accurately identifies senescent cells in both bulk and single-cell transcriptome. Trained on 602 samples from 52 senescence transcriptome datasets spanning 30 cell types, SenCID identifies six major senescence identities (SIDs). Different SIDs exhibit different senescence baselines, stemness, gene functions, and responses to senolytics. SenCID enables the reconstruction of senescent trajectories under normal aging, chronic diseases, and COVID-19. Additionally, when applied to single-cell Perturb-seq data, SenCID helps reveal a hierarch...
Source: Cell Metabolism - April 11, 2024 Category: Cytology Authors: Wanyu Tao Zhengqing Yu Jing-Dong J Han Source Type: research

Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
Cell Metab. 2024 Apr 3:S1550-4131(24)00089-5. doi: 10.1016/j.cmet.2024.03.010. Online ahead of print.ABSTRACTThe gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. This highlights a synergistic interaction among gut microbiota in regulating intestin...
Source: Cell Metabolism - April 6, 2024 Category: Cytology Authors: Mingliang Zhao Zhenxing Ren Aihua Zhao Yajun Tang Junliang Kuang Mengci Li Tianlu Chen Shouli Wang Jieyi Wang Huiheng Zhang Jijun Wang Tianhong Zhang Jiahui Zeng Xiaohua Liu Guoxiang Xie Penghong Liu Ning Sun Tianhao Bao Tongtong Nie Jingchao Lin Ping Liu Source Type: research

An integrated multi-omics analysis reveals osteokines involved in global regulation
In this study, we analyzed bone and extraskeletal tissues, osteoblast (OB) conditioned media, bone marrow supernatant (BMS), and serum, for basal osteokines and those responsive to aging and mechanical loading/unloading. We identified 375 candidate osteokines and their changes in response to aging and mechanical dynamics by integrating data from RNA-seq, scRNA-seq, and proteomic approaches. Furthermore, we analyzed their cellular sources in the bone and inter-organ communication facilitated by them (bone-brain, liver, and aorta). Notably, we discovered that senescent OBs secrete fatty-acid-binding protein 3 to propagate se...
Source: Cell Metabolism - April 4, 2024 Category: Cytology Authors: Wenquan Liang Tiantian Wei Le Hu Meijun Chen Liping Tong Wu Zhou Xingwei Duan Xiaoyang Zhao Weijie Zhou Qing Jiang Guozhi Xiao Weiguo Zou Di Chen Zhipeng Zou Xiaochun Bai Source Type: research