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Entire Mitral Valve Reconstruction Using Porcine Extracellular Matrix: Adding a Ring Annuloplasty
ConclusionWe successfully reconstructed the entire mitral valve using 2-ply small intestinal submucosal extracellular matrix (CorMatrix ®) combined with a flexible annuloplasty. The annuloplasty reduced the unphysiological systolic widening previously found with this reconstructive technique. However, the Simulus flex ring changed the physiological annular D-shape into a circular shape and hindered a correct unfolding of the leafle ts. Thus, we do not recommend a flexible ring in conjunction with this reconstructive technique; further investigations are needed to discover a more suitable remodelling annuloplasty. (Source:...
Source: Cardiovascular Engineering and Technology - March 19, 2024 Category: Cardiology Source Type: research

Literature Survey for In-Vivo Reynolds and Womersley Numbers of Various Arteries and Implications for Compliant In-Vitro Modelling
ConclusionThis paper compiles available human haemodynamic information, and highlights the paucity of information for some arteries. It also provides a method for optimal in-vitro experimental configuration. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 18, 2024 Category: Cardiology Source Type: research

Establishment of a Biaxial Testing System for Characterization of Right Ventricle Viscoelasticity Under Physiological Loadings
ConclusionThis work provides a new experimental tool to quantify the passive, biaxial viscoelasticity of ventricle free walls in both small and large animals. The dynamic mechanical tests showed frequency-dependent elastic and viscous behaviors of healthy rat RVs. But the ratio of dissipated energy to stored energy was maintained between frequencies. These findings offer novel baseline information on the passive viscoelasticity of healthy RVs in adult rats. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 11, 2024 Category: Cardiology Source Type: research

Standardized Bench Test Evaluation of Biomechanical Characteristics of Stents Used in Right Ventricular Outflow Tract Revalvulation
ConclusionThis study highlights the significant differences between the stents currently used in RVOT pre-stenting. Stents with good radial resistance are preferred, especially for calcified vessels, and flexibility is crucial for tortuous vessels. We proposed an algorithm for selecting the most suitable stent according to the need for radial force and flexibility, which will help inform clinicians considering RVOT revalvulation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 11, 2024 Category: Cardiology Source Type: research

Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure
ConclusionExcellent correlation between clinically measured and CFD model data shows that 3D CFD models of HLHS Norwood can be developed using standard angiography and echocardiographic data. The CFD analysis also revealed consistent changes in PA TAWSS, flow differential, and OSI as a function of shunt characteristics. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 8, 2024 Category: Cardiology Source Type: research

Influence of Remodeled ECM and Co-culture with iPSC-Derived Cardiac Fibroblasts on the Mechanical Function of Micropatterned iPSC-Derived Cardiomyocytes
ConclusionsThese combined observations highlight the important role CFs playin vivo and the need for models that enable a quantitative approach to examine interactions between the CFs and CMs, as well as the interactions of these cells with the ECM. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 6, 2024 Category: Cardiology Source Type: research

Patient-Specific Haemodynamic Analysis of Virtual Grafting Strategies in Type-B Aortic Dissection: Impact of Compliance Mismatch
ConclusionThis study suggests that by minimising graft length and matching its compliance to the native aorta whilst aligning with surgical requirements, the risk of LV hypertrophy may be reduced. This provides evidence that compliance-matching grafts may enhance patient outcomes. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 4, 2024 Category: Cardiology Source Type: research

Impact of Pressure Guidewire on Model-Based FFR Prediction
ConclusionFrom a clinical decision-making point of view, including of the pressure guidewire is potentially relevant only for intermediate stenosis cases. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 4, 2024 Category: Cardiology Source Type: research

12-Lead ECG Reconstruction Based on Data From the First Limb Lead
ConclusionsThe developed ECG reconstruction method holds significant potential for use in portable registration devices, screening procedures, and providing support for medical decision-making by healthcare specialists. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 29, 2024 Category: Cardiology Source Type: research

Aorta Segmentation in 3D CT Images by Combining Image Processing and Machine Learning Techniques
ConclusionThe proposed methodology achieved superior segmentation performance, compared to all compared segmentation techniques, in terms of the accuracy of the extracted 3D aortic model. Therefore, the proposed segmentation scheme could be used in clinical practice, such as in treatment planning and assessment, as it can speed up the evaluation of the medical imaging data, which is commonly a lengthy and tedious process. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 22, 2024 Category: Cardiology Source Type: research

A Monte Carlo Sensitivity Analysis for a Dimensionally Reduced-Order Model of the Aortic Dissection
ConclusionThis study highlights the necessity of comparing the results of the local and global sensitivity analyses to understand the significance of multiple lumped parameters. Because of the efficiency of the method, our approach is potentially useful to investigate and analyze medical planning. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 21, 2024 Category: Cardiology Source Type: research

Impact of the Different Chemical-Based Decellularization Protocols on the Properties of the Caprine Pericardium
ConclusionThe intact extracellular matrix and biomechanical properties like native tissues require optimal chemical doses and combinations.Graphical Abstract (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 12, 2024 Category: Cardiology Source Type: research

S4D-ECG: A Shallow State-of-the-Art Model for Cardiac Abnormality Classification
ConclusionIt is characterized by the elimination of pre-processing features and the availability of a low-complexity architecture that makes it suitable for implementation on numerous computing devices because it is easily implementable. Consequently, this algorithm exhibits considerable potential for practical applications in analyzing real-world ECG data. This model can be placed on the cloud for diagnosis. The model was also tested on lead II of the ECG alone and has demonstrated promising results, supporting its potential for on-device application. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 8, 2024 Category: Cardiology Source Type: research

Shape-Setting of Self-Expanding Nickel –Titanium Laser-Cut and Wire-Braided Stents to Introduce a Helical Ridge
ConclusionThis demonstrates the feasibility of an additional heat treatment regime to allow for helical shape-setting of laser-cut and wire-braided devices that may be applied to further designs. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 5, 2024 Category: Cardiology Source Type: research

A 3D-Printed Externally Adjustable Symmetrically Extensible (EASE) Aortic Annuloplasty Ring for Root Repair and Aortic Valve Regurgitation
ConclusionUsing an ex vivo VSARR model, the EASE ring successfully reduced AR by reducing the annular diameter and improving leaflet coaptation. With its broad applicability and ease of use, this device has the potential to have a significant impact on patients suffering worldwide from AR due to root aneurysms. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 18, 2024 Category: Cardiology Source Type: research