Nanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer
ConclusionsPLAG NPs carrying si-Notch1 had a great advantage in the extension of half-life circulation and targeting ability, providing a theoretical foundation for precise clinical treatment of CRC. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 12, 2024 Category: Cancer & Oncology Source Type: research
Advancing colorectal cancer therapy with biosynthesized cobalt oxide nanoparticles: a study on their antioxidant, antibacterial, and anticancer efficacy
ConclusionThis study verifies the successful synthesis of Co3O4 NPs and their potent antioxidant, antibacterial, and anticancer activities. The biosynthesized Co3O4 NPs represent a promising targeted method for CRC therapy. However, further research is needed to elucidate their mechanism of action and also their application in the clinical phase.Graphical Abstract (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 5, 2024 Category: Cancer & Oncology Source Type: research
Hypobaric hypoxia exposure regulates tissue distribution of nanomedicine for enhanced cancer therapy
ConclusionsThe liposomal nanomedicine with adjuvant hypobaric hypoxia exposure significantly inhibited the growth of orthotopic liver tumor for prolonged survival time, achieved by hypobaric hypoxia-promoted accumulation at tumor sites of the liver. It might be the first example of the application of adjuvant intermittent hypobaric hypoxia exposure in treating liver cancer. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 2, 2024 Category: Cancer & Oncology Source Type: research
A nano-cocktail of the PARP inhibitor talazoparib and CDK inhibitor dinaciclib for the treatment of triple negative breast cancer
ConclusionsThe efficacy and toxicity data suggest that further dose escalation can be pursued in order to achieve a stronger response. These data suggest the administration of combination therapy through the nano-cocktail leads to a better response than the use of free compounds and is a promising strategy for implementing combination therapy in the clinic. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 23, 2024 Category: Cancer & Oncology Source Type: research
Mild hyperthermia via gold nanoparticles and visible light irradiation for enhanced siRNA and ASO delivery in 2D and 3D tumour spheroids
ConclusionsIn summary, our findings offer a novel transfection approach for gene therapy applications in 2D and 3D tumour models. This approach is based on the use of mild photothermy mediated by AuNPs combined with visible laser irradiation that might pave the way for the spatial –temporal control of gene modulation. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Carboxymethyl-sagocellulose-stabilized Fe3O4 nanoparticles with 5-fluorouracil as photothermal agents for tumor ablation
ConclusionsThe combination of targeted delivery of 5-FU with photothermal therapy (PTT) looks promising for selective killing of cancer cells. Furthermore, SPIONs are an excellent contrasting agent for use in computerized tomography (CT) imaging for determining the tumor location and monitoring the progress of the therapy. The focus of this work was the oncological application of multifunctional Fe3O4-CMSC-5FU nanoparticle conjugates, with an emphasis on therapeutic, diagnostic and prognostic purposes. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 16, 2024 Category: Cancer & Oncology Source Type: research
Antitumor efficiency and photostability of newly green synthesized silver/graphene oxide nanocomposite on different cancer cell lines
In conclusion, the produced novel nanocomposite may be an effective way to treat different cell lines, and future work is to use the prepared nanomaterials as anticancer drug delivery in photothermal chemotherapy combination treatment. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - March 9, 2024 Category: Cancer & Oncology Source Type: research
Optimization and characterization of quercetin-loaded solid lipid nanoparticles for biomedical application in colorectal cancer
In conclusion, the prepared bio-nano QuR-SLNs might improve cytotoxicity and can act as an ideal carrier for the delivery of QuR and this preparation is used in the treatment of CRC. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 26, 2024 Category: Cancer & Oncology Source Type: research
HepG2 exosomes coated luteolin nanoparticles remodeling hepatic stellate cells and combination with sorafenib for the treatment of hepatocellular carcinoma
ConclusionsThis study suggests that the Exo-Lut-NP is a novel and promising biomimetic delivery system which can combine with sorafenib for HCC therapy. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 22, 2024 Category: Cancer & Oncology Source Type: research
Folic acid-functionalized PEGylated niosomes co-encapsulated cisplatin and doxoribicin exhibit enhanced anticancer efficacy
AbstractThe medical field is faced with the difficult task of developing a new approach to curing cancer, which is prevalent in organs such as the breast and ovaries and has a high mortality rate. Since chemotherapy is the conventional method of treatment, efforts are being made to improve it to help patients function better. Fortunately, with the use of nanocarriers and their remarkable ability to manage and direct drug delivery, progress is being made in cancer treatment. In addition, folic acid-coated nanocarriers offer several advantages in drug delivery, including improved stability, bioavailability, targeted delivery...
Source: Cancer Nanotechnology - February 13, 2024 Category: Cancer & Oncology Source Type: research
Investigation of mitochondria-dependent apoptosis pathway and lipid peroxidation level induced by biosynthesized silver nanoparticles: caspase-3 activation, BAK1/BCLx regulation and malondialdehyde production
AbstractNowadays, silver nanoparticles (AgNPs) have attracted the attention of many researchers due to their special physical, chemical, and biological properties. There is strong evidence that biogenic AgNPs can act as potent anticancer agents through the production of reactive oxygen species (ROS) and initiate the mitochondrial pathway of apoptosis. That is why we decided to useNepeta bracteata Benth flower extract for the first time to bio-synthesize AgNPs and study their cytotoxic and apoptotic effects on SK-BR-3 cells. AgNPs were biosynthesized at 70 °C after mixing silver nitrate and flower extract with a specific...
Source: Cancer Nanotechnology - February 8, 2024 Category: Cancer & Oncology Source Type: research
Opportunities and challenges of indocyanine green in gastrointestinal cancers for intraoperative and nano-medicine application
AbstractThe morbidity and mortality of gastrointestinal tumours remain high worldwide. Surgical resection is currently the most critical radical therapeutic schedule, while postoperative complications and sentinel lymph node (SLN) identification are closely related to the outcome. Indocyanine green (ICG)-mediated fluorescence imaging is increasingly being used in gastrointestinal surgery. It has been embraced by various surgical disciplines as a potential method to improve lymph node detection and enhance surgical field visualization. ICG can passively concentrate in SLN because of enhanced permeation and retention effects...
Source: Cancer Nanotechnology - February 7, 2024 Category: Cancer & Oncology Source Type: research
Polymer lipid hybrid nanoparticles encapsulated with Emodin combined with DOX reverse multidrug resistance of breast cancer via IL-6/JAK2/STAT3 signaling pathway
This study aims to explore the mechanisms by which the EMT involved in MDR and the E-PLNs exerted effects. The prepared E-PLNs were characterized by Dynamic light scattering, infrared spectroscopy, X-ray, and differential scanning calorimetry. The effects of drugs or treatments were evaluated by detecting cell viability, apoptosis, invasion, EMT markers, and MDR related proteins in vitro. The results showed that IL-6 could promote proliferation, EMT, invasion and MDR of MCF-7/ADR cells (induced from MCF-7 cells) by activating the JAK2/STAT3 signaling pathway, and these effects could be reversed by AG490 (JAK2 inhibitor) or...
Source: Cancer Nanotechnology - January 31, 2024 Category: Cancer & Oncology Source Type: research
The effect of doxorubicin curcumin co-loaded lipid nanoparticles and doxorubicin on osteosarcoma before surgery
ConclusionPreoperative application of DOX+CUR LPNs enables effective drug delivery to the tumor section by combining the antibacterial, antioxidant and anti-inflammatory effects of curcumin, which is co-wrapped in nanoparticles. It has the effect of promoting angiogenesis and damage repair, inhibiting inflammation-related factors, and protecting renal function, while adriamycin alone has drug resistance problems and toxic side effects, which can damage the patient's liver and kidney. Therefore, DOX+CUR LPNs are more effective than adriamycin alone, indicating that it can improve the therapeutic effect of the drug and reduc...
Source: Cancer Nanotechnology - January 31, 2024 Category: Cancer & Oncology Source Type: research
Mesoporous silica nanotechnology: promising advances in augmenting cancer theranostics
This article offers an extensive overview of MSN technology in cancer theranostics, outlining key directions for future research as well as the challenges that are involved in this aspect. We aim to underline the vitality of MSN technology and the relevance of current research and advancements in th is field to potentially enhance clinical outcomes through the provision of more precise and focused theranostic approaches. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - January 31, 2024 Category: Cancer & Oncology Source Type: research
