Genomic Landscapes of Acral Melanomas in East Asia
Conclusion: The genomic landscape of AM provides an important resource for applying novel targeted therapies in this rare disease. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: CHANG, J. W.-C., HSIEH, J.-J., WU, C.-E., LIM, A. H., NG, C. C.-Y., TEH, B. T., CHAN, J. Y. Tags: Articles Source Type: research
Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3
Conclusion: The patient sequentially developed AML and ALL with three leukemia-specific genomic abnormalities in her bone marrow cells, two of which were KMT2A-rearrangements. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., ANDERSEN, K., EILERT-OLSEN, M., ZELLER, B., MUNTHE-KAAS, M. C., BUECHNER, J., OSNES, L. T. N., MICCI, F., HEIM, S. Tags: Articles Source Type: research
Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate
Conclusion: IL-10:rs1800871 and rs1800872 SNPs are associated with advanced stage of LSCC. The genotypic distribution of IL-10 SNPs does not influence the survival rate of LSCC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: PASVENSKAITE, A., LIUTKEVICIENE, R., GEDVILAITE, G., VILKEVICIUTE, A., LIUTKEVICIUS, V., ULOZA, V. Tags: Articles Source Type: research
Noncoding RNAs Serve as the Deadliest Universal Regulators of all Cancers
Numerous cancer drivers have been identified, but they are specific to a given cancer type and condition; universal cancer drivers and universal cancer mechanisms still remain largely unclear. Here, we identified the deadliest universal drivers for all cancers via developing algorithms to analyze massive RNAseqs and clinical data from The Cancer Genome Atlas (TCGA). In general, noncoding RNAs primarily serve as the most important inducers and suppressors for all types of cancers. In particular, pseudogenes are primary inducers, and specifically the antisense RNA RP11–335K5.2 serves as the most universal cancerous dri...
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: WANG, A., HAI, R. Tags: Articles Source Type: research
Metabolic Profiling of Praziquantel-mediated Prevention of Opisthorchis viverrini-induced Cholangiocyte Transformation in the Hamster Model of Cholangiocarcinoma
Conclusion: These findings might avail the development of a preventive strategy for CCA in high-risk populations. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: PROMMAJUN, P., PHETCHARABURANIN, J., NAMWAT, N., KLANRIT, P., SA-NGIAMWIBOOL, P., THANEE, M., DOKDUANG, H., KITTIRAT, Y., LI, J. V., LOILOME, W. Tags: Articles Source Type: research
Transcriptomic Profiling Predicts Multiple Pathways and Molecules Associated With the Metastatic Phenotype of Oral Cancer Cells
Conclusion: Inflammation and NF-kB may be involved in the metastasis of OSCC, and CSF2 is a promising diagnostic and therapeutic molecule. Moreover, HSC-3-M3 cells are a useful cell line model for studying OSCC progression. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: IDETA, Y., TAGAWA, T., HAYASHI, Y., BABA, J., TAKAHASHI, K., MITSUDO, K., SAKURAI, K. Tags: Articles Source Type: research
microRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis
The annual death toll for gastric cancer is in the range of 700,000 worldwide. Even in patients with early-stage gastric cancer recurrence within five years has been observed after surgical resection and following chemotherapy with therapy-resistant features. Therefore, the identification of new targets and treatment modalities for gastric cancer is of paramount importance. In this review we focus on the role of microRNAs with documented efficacy in preclinical xenograft models with respect to growth of human gastric cancer cells. We have identified 31 miRs (-10b, -19a, -19b, -20a, -23a/b, -25, -27a-3p, -92a, -93, -100, -1...
Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., NOPORA, A. Tags: Reviews Source Type: research
Index
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Tags: Index Source Type: research
Genetic Analysis Identifies the Role of HLF in Renal Cell Carcinoma
Conclusion: These findings implicate the potential protective role of HLF in the progression of RCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: HUANG, C.-Y., HUANG, S.-P., HSUEH, Y.-M., CHEN, L.-C., LU, T.-L., BAO, B.-Y. Tags: Clinical Studies Source Type: research
Atypical Mesonephric Hyperplasia of the Uterus Harbors Pathogenic Mutation of Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRAS) and Gain of Chromosome 1q
Conclusion: Atypical MNH is a potential premalignant lesion in which KRAS mutation and chromosome 1q gain play an important role in the early stage of mesonephric carcinogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: KIM, H., YOON, N., WOO, H. Y., LEE, E.-J., DO, S.-I., NA, K., KIM, H.-S. Tags: Clinical Studies Source Type: research
Targeted Genomic Sequencing Reveals Different Evolutionary Patterns Between Locally and Distally Recurrent Glioblastomas
Conclusion: Locally and distally recurrent glioblastomas exhibit different evolutionary patterns. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: YOON, N., KIM, H.-S., LEE, J. W., LEE, E.-J., MAENG, L.-S., YOON, W. S. Tags: Experimental Studies Source Type: research
Comparison of Benign and Malignant Pilomatricomas Using Whole-exome Sequencing
Conclusion: This study, the first comparative analysis of benign and MP through whole-exome analysis, identified a novel oncogenic mutation in FGFR4. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: YEO, M.-K., BAE, G. E. Tags: Experimental Studies Source Type: research
Gigantol Targets MYC for Ubiquitin-proteasomal Degradation and Suppresses Lung Cancer Cell Growth
Conclusion: Gigantol was found to inhibit lung cancer proliferation through induction of GSK3β-mediated MYC ubiquitin-proteasome degradation. These data suggest gigantol to be a promising candidate for novel strategy in inhibition of lung cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: LOSUWANNARAK, N., ROYTRAKUL, S., CHANVORACHOTE, P. Tags: Experimental Studies Source Type: research
lincRNA-RP11400K9.4 Regulates Cell Survival and Migration of Breast Cancer Cells
Conclusion: RP11-400K9.4 participates in the modulation of migration and survival processes probably via the BIRC3/NFĸB pathway. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: FERNANDEZ-ROJAS, M. A., MELENDEZ-ZAJGLA, J., LAGUNAS, V. M. Tags: Experimental Studies Source Type: research
Normal Mouse Brain Proteome II: Analysis of Brain Regions by High-resolution Mass Spectrometry
Conclusion: These data represent the most comprehensive proteomic map of the normal mouse brain and they might further be used in studies related to brain diseases, including cancer and neurodegenerative diseases. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: KOROVESI, A. G., ANAGNOSTOPOULOS, A. K., PIERROS, V., STRAVOPODIS, D. J., TSANGARIS, G. T. Tags: Experimental Studies Source Type: research
