Cuproptosis: Advances in Stimulus-Responsive Nanomaterials for Cancer Therapy
Adv Healthc Mater. 2024 Apr 15:e2400652. doi: 10.1002/adhm.202400652. Online ahead of print.ABSTRACTCuproptosis, a recently identified non-apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since its initial report in 2022, strategies inducing or amplifying cuproptosis for cancer treatment emerge. The engineering of nano-systems to elicit cuproptosis effectively circumvents constraints associated with conventional small-molecule pharmaceutical interventions, presenting novel prospects for oncological therapy. Stimulus...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Jiacheng Lu Yuqing Miao Yuhao Li Source Type: research
Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment
Environ Toxicol. 2024 Apr 15. doi: 10.1002/tox.24280. Online ahead of print.ABSTRACTOsteosarcoma is a highly aggressive cancer prevalent among adolescents and young adults, notorious for its tendency to metastasize to the lungs. This research delves into the molecular foundations of osteosarcoma by examining the role of the Hippo signaling pathway and its interaction with the tumor immune microenvironment (TME). Through analysis of transcriptomic data from the TARGET-OS dataset and control samples from GTEx, we identified a set of 131 genes that link high expression profiles in osteosarcoma with the Hippo pathway. A focuse...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Huayan Ma Yuxian Zhang Jing Li Tiantian Xie Zhi Zhao Source Type: research
The Effect of Melatonin on Increasing the Health Related Quality of Life in Non-Metastatic Breast Cancer Patients: Three-Year Follow up a Clinical Trial
CONCLUSION: Long-term use of 18 mg of melatonin for 3 years in patients with non-metastatic breast cancer can lead to an increase in the patients' quality of life.PMID:38622853 | DOI:10.1177/15347354241237520 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zahra Keshtpour Amlashi Fatemeh Sheida Robab Anbiaee Leili Tapak Seyed Rohallah Hosseini Hossein Mosaedian Nastaran Barati Source Type: research
Urolithin A affects cellular migration and modulates matrix metalloproteinase expression in colorectal cancer cells
Cell Biochem Funct. 2024 Apr;42(3):e4019. doi: 10.1002/cbf.4019.ABSTRACTColorectal cancer (CRC) is the world's second most common gastrointestinal malignancy. Preventing tumor cell proliferation and dissemination is critical for patient survival. Polyphenols have a variety of health advantages and can help prevent cancer. The current study examined different cellular activities of the gut-microbiota metabolite urolithin A (UA) on several colon cancer cell lines. The results revealed that UA suppressed cell growth in a dose- and time-dependent manner. In the current investigation, UA substantially affected cell migration in...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Mohammad S El-Wetidy Mohamad I Rady Islam Rady Hamed Helal Source Type: research
Efficacy of a web-based psychoeducational intervention, Fex-can sex, for young adult childhood cancer survivors with sexual dysfunction: A randomized controlled trial
CONCLUSION: The Fex-Can Sex intervention shows potential to improve sexual function, especially among those with greater dysfunction. To increase adherence and effect, we recommend the intervention to be further developed including more tailored content.CLINICAL TRIAL REGISTRATION: ISRCTN Registry, trial number: 33081791 (registered on November 27, 2019).PMID:38623084 | PMC:PMC11016752 | DOI:10.1016/j.invent.2024.100739 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Kristina Fagerkvist Kirsi Jahnukainen Lisa Ljungman Claudia Lampic Lena Wettergren Source Type: research
Tempol effect on oxidative and mitochondrial markers in preclinical models for prostate cancer
CONCLUSION: Tempol can be considered a beneficial therapy for PCa treatment considering its antioxidant and low toxicity properties, however the PCa progression must be evaluated to get successful therapy.PMID:38623092 | PMC:PMC11015989 | DOI:10.1093/toxres/tfae056 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Isabela Maria Urra Rossetto Felipe Rabelo Santos Heloina Mariano da Silva Elaine Minatel Mariana Mesquitta Marcos Jos é Salvador F ábio Montico Val éria Helena Alves Cagnon Source Type: research
Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials
CONCLUSIONS: Aerobic and resistance exercises are tolerable and effective adjunct therapies to reduce cancer-related pain while also improving physical function, fatigue and mood. Future RCTs of dose, frequency, compliance and exercise type in specific cancer settings are required.PMID:38623224 | PMC:PMC11016720 | DOI:10.1016/j.heliyon.2024.e29193 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Philip D Austin Wei Lee Daniel Sj Costa Alison Ritchie Melanie R Lovell Source Type: research
Predicting prostate cancer recurrence: Introducing PCRPS, an advanced online web server
CONCLUSION: Overall, our study provides an attractive tool to further guide the clinical management and individualized treatment for PCa.PMID:38623253 | PMC:PMC11016622 | DOI:10.1016/j.heliyon.2024.e28878 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Xianya He Sheng Hu Chen Wang Yongjun Yang Zhuo Li Mingqiang Zeng Guangqing Song Yuanwei Li Qiang Lu Source Type: research
Proposal of a new dermoscopic criterion for pigmented basal cell carcinoma: a multicentre retrospective study
Dermatol Reports. 2023 Aug 24;16(1):9691. doi: 10.4081/dr.2023.9691. eCollection 2024 Mar 12.ABSTRACTDermoscopy is widely used for the diagnosis of skin cancer and it increases the accuracy of basal cell carcinoma (BCC) detection. BCC dermoscopic criteria have been updated and divided into vascular, pigment-related, and non-vascular/non-pigment-related. Our multicenter retrospective study tested a new dermoscopic pigment-related characteristic to detect pigmented BCC (pBCC) [brown homogeneous blotches (BHB)]. Cases of pBCC were collected from the databases of IDI-IRCCS of Rome and from three Italian private dermatology cen...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Roberto Manca Anna Dattolo Francesco Valenzano Marina Castriota Alessandro Martella Giovanna Galdo Giuseppe Argenziano Damiano Abeni Luca Fania Source Type: research
Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020)
CONCLUSION: While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.PMID:38623490 | PMC:PMC11017855 | DOI:10.1002/jgh3.13064 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Hassam Ali Rizwan Ishtiaq Brandon Tedder Joshua Zweigle Romina Nomigolzar Dushyant S Dahiya Vishali Moond Amir Humza Sohail Pratik Patel Debargha Basuli Hans L Tillmann Source Type: research
Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development
CONCLUSION: HOTAIR, IDO1, KIF20A, NR5A2, and RRM2 were identified as promising candidate antigens for the development of an LGG mRNA vaccine, particularly offering potential benefits to FS2 and FS4 patients.PMID:38623558 | PMC:PMC11018127 | DOI:10.2147/PGPM.S449230 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Zhenxiang Zhao Na Xing Hao Guo Jianfeng Li Guozhu Sun Source Type: research
Epstein-Barr Virus DNA Is Associated With Conjunctival Squamous Cell Carcinomas: A Case-Control Study From Zimbabwe
Open Forum Infect Dis. 2024 Mar 25;11(4):ofae165. doi: 10.1093/ofid/ofae165. eCollection 2024 Apr.ABSTRACTIncidence of conjunctival squamous cell carcinoma (cSCC) in Zimbabwe is >30-fold higher than the global average. cSCC risk is notably higher among people with human immunodeficiency virus, implicating impaired immune response and a yet unknown infectious etiology. Formalin-fixed, paraffin-embedded blocks from Zimbabwe, comprising conjunctival precancer (n = 78), invasive cSCC cases (n = 148) and nonmalignant eye lesions (n = 119), were tested for multiple DNA viruses using Luminex bead-based technology. Epstein-Barr...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Racheal S Dube Mandishora Luisa Galati Richard R Reich Jean-Damien Combes Sandrine McKay-Chopin Rudo Makunike-Mutasa Rangarirai Masanganise Bevele Gwambiwa Tricia Magombei Francesco Alfredo Zito Pagona Lagiou Gary M Clifford Anna R Giuliano Anna E Coghill Source Type: research
Thymosin alpha1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery
This study aimed to investigate the efficacy of thymosin α1 combined with XELOX in improving immune function and reducing serum tumor markers in patients with colorectal cancer (CRC) after radical surgery. A total of 180 patients who underwent radical surgery for CRC were divided into two groups: an observation group (n = 94) receiving thymosin α1 in combination with XELOX and a control group (n = 86) receiving XELOX alone. Immune function, inflammatory factor levels, serum tumor markers, and quality of life were assessed before and after treatment. Adverse reactions and recurrence rates were compared between the two gro...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Li Sha Hao Zhang Xiwei Zhang Source Type: research
Application Value of CYFRA21-1 Combined with NSE, CEA, and SCC-Ag in Lung Cancer
CONCLUSIONS: The combined assay of CYFRA21-1, NSE, and CEA addresses the aspects of accuracy, sensitivity, specificity, and economic cost and should be considered as a potential diagnostic test in LC.PMID:38623667 | DOI:10.7754/Clin.Lab.2023.230662 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Yuping Fu Dandan Li Ya Zhu Sha Yan Xia Wang Zhenshuai Lian Qi Xie Zhi'an He Source Type: research
Comprehensive Assessment of the Intrinsic Pancreatic Microbiome
CONCLUSIONS: Our analysis of the pancreatic microbiome demonstrated very low intrinsic biomass that is relatively conserved across diverse neoplastic conditions and thus unlikely to drive malignant transformation.PMID:38623754 | DOI:10.1097/SLA.0000000000006299 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Austin M Eckhoff Ashley A Fletcher Matthew S Kelly Anders Dohlman Caitlin A McIntyre Xiling Shen Matthew K Iyer Daniel P Nussbaum Peter J Allen Source Type: research
