NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation
Cancer Biol Ther. 2024 Dec 31;25(1):2334463. doi: 10.1080/15384047.2024.2334463. Epub 2024 Apr 3.ABSTRACTNeurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was obse...
Source: Cancer Biology and Therapy - April 3, 2024 Category: Cancer & Oncology Authors: Fan Guo Wulin Wen Zhipeng Mi Chao Long Qiangyou Shi Meihua Yang Jia Zhao Ruixia Ma Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
