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Total 12506 results found since Jan 2013.

How to Teach Laboratory Stewardship in the Undergraduate Medical Curriculum?
CONCLUSIONS: The online educational tool will focus on the curricular needs identified, using a multidisciplinary approach for development and implementation. PMID: 31836880 [PubMed - in process]
Source: American Journal of Clinical Pathology - December 15, 2019 Category: Pathology Authors: Roth CG, Huang WY, Caruso AC, Sekhon N, Kung DH, Greely JT, Du YB, Holder-Haynes JG, Little JE, Fielder EK, Ismail NJ Tags: Am J Clin Pathol Source Type: research

Musical encounters on the borderline. Patterns of mutuality in musical improvisations with Borderline Personality Disorder
This study focused on intersubjective relatedness with clients with Borderline Personality Disorder (BPD) within the field of Music Therapy. Clinical improvisation is increasingly recognized as a mean to develop or re-live patterns of mutuality, and by mutuality we mean the emergence of a polyphonic flow founded on the forces that constantly makes us balance between dependency and independency. Recent research addresses how people with BPD relate to others in Music Therapy. What is currently lacking is a detailed tracking of mutual aspects of the musical modality emerging in music therapy improvisations. This paper details...
Source: Arts in Psychotherapy - December 15, 2019 Category: Psychiatry & Psychology Source Type: research

Resisting ethnic inequities in advanced breast cancer: a call to action.
Authors: Kereama-Royal I, Jones S, Wijohn EL, Doole C, Burgess EL, Came H Abstract Māori women with advanced breast cancer are less than half as likely as their Pākehā counterparts to reach the five-year survival mark. We argue that this inequity is unacceptable. We trace the inequity back to i) inadequate screening and risk assessment, ii) lack of support for patient navigation, iii) failure to offer accessible state-of-the-art treatments, and iv) delays in receiving life-prolonging care. We posit that each of these factors is a site of institutional racism and privilege as they cause Māori women to experience...
Source: New Zealand Medical Journal - December 14, 2019 Category: General Medicine Tags: N Z Med J Source Type: research

Examining the racial-ethnic continuum and perceptions of police misconduct - Graziano LM, Gauthier JF.
Some research suggests a racial-ethnic hierarchy exists as to perceptions of police, with African-Americans exhibiting the most negative attitudes, Whites the most positive, and Hispanics holding more intermediate attitudes. Other findings regarding Hispan...
Source: SafetyLit - December 14, 2019 Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news

Internet gaming, embodied distress, and psychosocial well-being: A syndemic-syndaimonic continuum
Publication date: Available online 12 December 2019Source: Social Science & MedicineAuthor(s): Jeffrey G. Snodgrass, Michael G. Lacy, Steven W. ColeAbstractWe examine internet gaming-related suffering as a novel syndemic most prevalent among contemporary emerging adults. Synthetic analysis of our prior research on internet gaming and health affirms how social factors and mental and physical wellness mutually condition each other in this online play context. Employing biocultural anthropological mixed methods, we focus on statistical interactions between intensive gaming and social well-being in relation to genomic markers ...
Source: Social Science and Medicine - December 14, 2019 Category: Psychiatry & Psychology Source Type: research

How to Give Up Alcohol
As socially acceptable as alcohol is, it is also a very dangerous habit. It can cause negative consequences rather quickly. Our country embraces a drinking culture, which makes it difficult to decipher a period of excess or actual alcohol addiction. As such, it is important to pay attention to whether or not you have the ability to give up alcohol, because this inability is a hallmark of addiction. Luckily, there are ways you can learn how to give up alcohol for good in your life. Set Your Intentions Why do you want to quit drinking? Write down your intentions and put them somewhere that is visible to you every day. A con...
Source: Cliffside Malibu - December 13, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol disorder alcohol treatment alcohol treatment center alcohol treatment facility alcohol use alcoholic Source Type: blogs

Overcoming Holiday Barriers to Recovery
The holidays are just around the corner and, with only a few weeks to go until the festivities begin, many individuals dealing with addictions may be thinking that now would be the worst possible time to finally get treatment. This couldn’t be further from the truth. If you or your loved one needs treatment for addiction sooner than later, we’ve put together some of the most common holiday barriers to recovery and how to overcome them. Holiday Barriers to Recovery: Sacrificing One for Many The holidays are a wonderful time of year full of love, tradition, the spirit of giving and coming together with family. It could ...
Source: Cliffside Malibu - December 13, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Recovery Holidays drug addiction recovery family support family therapy holiday parties Successful Addiction Recovery Source Type: blogs

Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait.
Authors: Jahromi M, Al-Ozairi E Abstract The incidence rate of type 1 diabetes in Kuwait had been increasing exponentially and has doubled in children ≤ 14 years old within almost two decades. Therefore, there is a dire need for a careful systematic familial cohort study. Several immunogenetic factors affect the pathogenesis of the disease. The human leukocyte antigen (HLA) accounts for the major genetic susceptibility to the disease. The triggering agents initiate disease onset by type 1 destruction of pancreatic β-cells. Both HLA and anti-islet antibodies can be used to characterize, predict susceptibility...
Source: Disease Markers - December 13, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Urinary Prostaglandin E2 is a biomarker of early adaptive hyperfiltration in solitary functioning kidney
ConclusionIncreased urinary PGE2 from elevated SNGFR and consequently increased FFSS during early stage of CKD precedes overt microalbuminuria and is a biomarker for early hyperfiltration-induced injury in individuals with SFK.
Source: Prostaglandins and Other Lipid Mediators - December 13, 2019 Category: Lipidology Source Type: research

Does healthcare voucher provision improve utilisation in the continuum of maternal care for poor pregnant women? Experience from Bangladesh.
Conclusion: The voucher programme enhanced uptake of the complete continuum of maternal care and the benefits extended to the most vulnerable women. However, a lack of continued transition through the continuum of maternal care was identified. This insight can assist in designing effective interventions to prevent intermittent or interrupted care-seeking. Programmes that improve access to quality healthcare in pregnancy, childbirth and the postnatal period can have wide-ranging benefits. A coherent continuum-based approach to understanding maternal care-seeking behaviour is thus expected to have a greater impact on materna...
Source: Global Health Action - December 13, 2019 Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research

Krogh's capillary recruitment hypothesis, 100 years on: Is the opening of previously closed capillaries necessary to ensure muscle oxygenation during exercise?
Abstract In 1919, August Krogh published his seminal work on skeletal muscle oxygenation. Krogh's observations indicated that muscle capillary diameter is actively regulated, rather than a passive result of arterial blood flow regulation. Indeed, combining a mathematical model with the number of ink-filled capillaries he observed in muscle cross-sections taken at different workloads, Krogh was able to account for muscle tissue's remarkably efficient oxygen extraction during exercise in terms of passive diffusion from nearby capillaries. Krogh was awarded the 1920 Nobel Prize for his account of muscle oxygenation. ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 13, 2019 Category: Physiology Authors: Angleys H, Østergaard L Tags: Am J Physiol Heart Circ Physiol Source Type: research

THCB Spotlights: Omri Shor, CEO & Co-founder of Medisafe
Today on THCB Spotlights, Matthew chats with Omri Shor, the CEO and Co-founder of Medisafe. Way back in 2014, Medisafe took home the gold at Health 2.0, winning first place at Traction. Since then, their consumer medication management tool has evolved quite a bit. While the app is available for patients with over 6 million users today, they also have folks across the health care continuum partnering with Medisafe to manage the medication journey for their patients. Matthew picks Omri’s brain on how things will continue to evolve, what he’s learned to help people in health care think about the problem of medicat...
Source: The Health Care Blog - December 12, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health 2.0 Health Tech Health Technology Matthew Holt Start-Ups THCB Spotlights medication management Medisafe Omri Shor Source Type: blogs

Associations between area-level deprivation, rural residence, physician density, screening policy and late-stage colorectal cancer in Canada
ConclusionsSocial disparities in late-stage CRC diagnosis are modest. Continued surveillance of these disparities may be warranted as provinces continue to promote early cancer detection through screening, and stage distributions may change overtime.
Source: Cancer Epidemiology - December 12, 2019 Category: Cancer & Oncology Source Type: research

Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior
Pericytic tumors comprise a histologic continuum of neoplasms with perivascular myoid differentiation, which includes glomus tumors, myopericytoma, myofibroma, and angioleiomyoma. Despite their morphologic overlap, recent data suggest a dichotomy in their genetic signatures, including recurrent NOTCH gene fusions in glomus tumors and PDGFRB mutations in myofibromas and myopericytomas. Moreover, SRF-RELA fusions have been described in a subset of cellular variants of myofibroma and myopericytoma showing myogenic differentiation. Triggered by an index case of an unclassified cellular myoid tumor showing a novel SRF-ICA1L fus...
Source: The American Journal of Surgical Pathology - December 12, 2019 Category: Pathology Tags: Original Articles Source Type: research

Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population
Publication date: 10 December 2019Source: Cell Reports, Volume 29, Issue 11Author(s): Rebecca Leylek, Marcela Alcántara-Hernández, Zachary Lanzar, Anja Lüdtke, Oriana A. Perez, Boris Reizis, Juliana IdoyagaSummaryPlasmacytoid dendritic cells (pDCs) are sensor cells with diverse immune functions, from type I interferon (IFN-I) production to antigen presentation, T cell activation, and tolerance. Regulation of these functions remains poorly understood but could be mediated by functionally specialized pDC subpopulations. We address pDC diversity using a high-dimensional single-cell approach: mass cytometry (CyTOF). Our an...
Source: Cell Reports - December 12, 2019 Category: Cytology Source Type: research

IJERPH, Vol. 16, Pages 5074: Farmer Burnout in Canada
dra Hoy While farmers in several countries worldwide are reported to be at higher risk for poor mental health outcomes like chronic stress, depression, and anxiety, there is a paucity of research on burnout in farmers. This cross-sectional study used an online survey administered between September 2015 and February 2016 to investigate burnout (as measured by the Maslach Burnout Inventory–General Survey (MBI–GS)) amongst farmers in Canada. The specific objectives were to measure the three components of burnout (exhaustion, cynicism, and professional efficacy), and to explore potential associa...
Source: International Journal of Environmental Research and Public Health - December 12, 2019 Category: Environmental Health Authors: Andria Jones-Bitton Briana Hagen Stephen J. Fleming Sandra Hoy Tags: Article Source Type: research

All About Blood Alcohol Levels
Blood alcohol levels, also known as blood alcohol content, is a way to measure an individual’s level of alcohol intoxication. It represents the percentage of alcohol that is concentrated in the bloodstream. Blood alcohol levels are used for legal purposes, such as measuring individuals for drunk driving incidents, and for medical purposes, such as testing patients who enter the hospital for alcohol-related health issues. What Are The Different Blood Alcohol Levels? There are many factors that influence a person’s blood alcohol levels. They can include body weight, gender, genetics, tolerance to alcohol, drinking patte...
Source: Cliffside Malibu - December 11, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Alcohol Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use Alcoholics Anonymous Source Type: blogs

How to Ask Your Doctor About Addiction Treatment
Learning more information about the addiction treatment process can be difficult if you do not know where to start looking. One of the many places individuals may begin their search is with their primary care provider, which makes it important to know how to ask your doctor about addiction treatment. There are many reasons an individual may seek addiction treatment advice from their doctor, including: The doctor is prescribing medications that they believe they have become addicted to The individual is suffering from a condition that they believe their addiction is worsening or impacting The individual doesn’t have any...
Source: Cliffside Malibu - December 11, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Addiction Recovery Addiction Treatment and Program Resources doctor doctors treatment center treatment facilities treatment facility treatment options treatment programs Source Type: blogs

Signs of Opioid Use
What are the Signs of Opioid Use? Opioids are a group of drugs derived naturally from the poppy plant, or are man-made in a laboratory, also known as synthetic opioids. Opioids are generally prescribed to individuals suffering from chronic pain, whether from surgery, a major injury or other health issues. Legally prescribed opioids include morphine, codeine, and oxycodone, while illegal opioids include heroin. It is easy to know if an individual is using opioids if they’ve been prescribed, but it is also important to know the signs of opioid use if it has crossed the line into an addiction. Signs and Symptoms There are m...
Source: Cliffside Malibu - December 11, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Addiction to Pharmaceuticals Painkiller opioid opioids prescription drug abuse prescription drug addiction prescription drug detox prescription drugs prescription medication signs of addiction Source Type: blogs

Opioids and Mental Health
Opioids are a group of very strong pain relievers used to relieve pain after a surgery or traumatic injury. They are much more effective than over-the-counter pain relievers, however, they are also highly addictive. People who suffer from mental health conditions are much more likely to become addicted to opioids, making it important to understand the link between opioids and mental health. The Connection Between Addiction to Opioids and Mental Health People with mood and anxiety disorders are twice as likely to use opioids as people without mental health disorders They are also more than three times as likely to misuse ...
Source: Cliffside Malibu - December 11, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Addiction to Pharmaceuticals Mental Health mental health costs mental health coverage mental illness opiate addiction opiates opioid opioid crisis opioids Source Type: blogs

Diffusion assisted interaction of shear bands in metallic glasses
Publication date: Available online 10 December 2019Source: Journal of Alloys and CompoundsAuthor(s): Zsolt Kovács, Ádám Révész, Mohammed Ezzeldien, János LendvaiAbstractShear bands were formed at room temperature in Zr44Ti11Cu10Ni10Be25 bulk metallic glass subjected to torsional deformation. Shear offset distribution was determined quantitatively for intersecting bands and compared to an elastic continuum shear defect model applied to similar band arrangements. The model reproduced the measured offset distribution, the residual stress field and different asymmetrical features of the band interaction. Differences betw...
Source: Journal of Alloys and Compounds - December 11, 2019 Category: Chemistry Source Type: research

Fronto-parietal engagement in response inhibition is inversely scaled with attention-deficit/hyperactivity disorder symptom severity
Conclusions: The results highlight the importance of IPS engagement in response inhibition and suggest that IPS modulation may be driven by top-down control from the IFG. Moreover, the current findings force the point of treating ADHD as a continuum whereby brain correlates are scaled with severity of the disorder, and point to the potential use of individual differences in the modulation of IPS activation and connectivity as a neuromarker of ADHD.
Source: NeuroImage: Clinical - December 11, 2019 Category: Radiology Source Type: research

Improving the relevance of randomised trials to primary care: a qualitative study investigating views towards pragmatic trials and the PRECIS-2 tool
ConclusionsTo maximize the relevance of research directed at primary care, trials should be conducted with the same populations and settings that are found in primary care. Across other aspects of trials it is not always necessary to match the conditions found in practice.
Source: Trials - December 11, 2019 Category: Research Source Type: clinical trials

Structural and functional disconnections convey the pathology progression along the Alzheimer’s continuum
Molecular Psychiatry, Published online: 11 December 2019; doi:10.1038/s41380-019-0612-0Structural and functional disconnections convey the pathology progression along the Alzheimer’s continuum
Source: Molecular Psychiatry - December 11, 2019 Category: Psychiatry Authors: Massimo Filippi Silvia Basaia Elisa Canu Francesca Imperiale Giuseppe Magnani Monica Falautano Giancarlo Comi Andrea Falini Federica Agosta Source Type: research

Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD.
Abstract Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with currently no cure. These two diseases share a clinical continuum with overlapping genetic causes. Mutations in the CHMP2B gene are found in patients with ALS, FTD and ALS-FTD. To highlight deregulated mechanisms occurring in ALS-FTD linked to the CHMP2B gene, we performed a whole transcriptomic study on lumbar spinal cord from CHMP2Bintron5 mice, a model that develops progressive motor alterations associated with dementia symptoms reminiscent of both ALS and FTD. To gain insight into the transcriptomic change...
Source: Neurobiology of Disease - December 11, 2019 Category: Neurology Authors: Robin W, Sylvie DG, Florian P, Céline K, Alexandre H, Jean-Philippe L, Frédérique R Tags: Neurobiol Dis Source Type: research

Mathematical Models of Cancer Cell Plasticity.
Authors: Weerasinghe HN, Burrage PM, Burrage K, Nicolau DV Abstract Quantitative modelling is increasingly important in cancer research, helping to integrate myriad diverse experimental data into coherent pictures of the disease and able to discriminate between competing hypotheses or suggest specific experimental lines of enquiry and new approaches to therapy. Here, we review a diverse set of mathematical models of cancer cell plasticity (a process in which, through genetic and epigenetic changes, cancer cells survive in hostile environments and migrate to more favourable environments, respectively), tumour growth...
Source: Journal of Oncology - December 10, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Microbial disease management in agriculture: Current status and future prospects
This article summarizes various disease management strategies practiced by farmers and the application of bacterial viruses in controlling plant pathogenic bacteria. It also highlights other possible methods for plant disease control in the near future for sustainable organic agricultural practices.
Source: Biocatalysis and Agricultural Biotechnology - December 10, 2019 Category: Biotechnology Source Type: research

Children With Metabolically Healthy Obesity: A Review
Children with “metabolically healthy obesity” (MHO) are a distinct subgroup of youth with obesity, who are less prone to the clustering of cardiometabolic risk factors. Although this phenotype, frequently defined by the absence of metabolic syndrome components or insulin resistance, was first described during the early 1980s, a consensus-based definition of pediatric MHO was introduced only recently, in 2018. The purpose of this review was to concisely summarize current knowledge regarding the MHO phenomenon in youth. The prevalence of MHO in children varies from 3 to 87%, depending on the definition used and the param...
Source: Frontiers in Endocrinology - December 10, 2019 Category: Endocrinology Source Type: research

Lack of evidence for a continuum between hepatorenal syndrome and acute tubular necrosis
We read with great interest the review article “News in Pathophysiology, Definition, and Classification of Hepatorenal Syndrome: a step beyond the International Club of Ascites (ICA) Consensus document” by Angeli et al. published recently in Journal of Hepatology.1 The review discusses a number of important issues related to acute kidney inj ury (AKI) in cirrhosis and proposes modifications to the definition, classification, pathogenesis, and management of hepatorenal syndrome (HRS). HRS is a specific type of kidney impairment unique to patients with cirrhosis characterized by a sudden and severe impairment in kidney f...
Source: Journal of Hepatology - December 10, 2019 Category: Gastroenterology Authors: Cristina Sol é, Elsa Solà, Patrick S. Kamath, Pere Ginès Tags: Letter to the Editor Source Type: research

Delays and Barriers to Cancer Care in Low‐ and Middle‐Income Countries: A Systematic Review
Conclusion.Early diagnosis strategies should address barriers during all three intervals contributing to late presentation in LMICs. Standardization in studying and reporting delay intervals in LMICs is needed to monitor progress and facilitate comparisons across settings.Implications for Practice.This review draws the attention of cancer implementation scientists globally. The findings highlight the significant delays that occur throughout the cancer care continuum in low‐ and middle‐income countries and describe common barriers that cause them. This review will help shape the global research agenda by proposing metri...
Source: The Oncologist - December 10, 2019 Category: Cancer & Oncology Authors: Nathan R. Brand, Liang G. Qu, Ann Chao, Andre M. Ilbawi Tags: Global Health and Cancer Source Type: research

Community Healthcare Quality Standards to Prevent Acute Kidney Injury and its Consequences
As the incidence of acute kidney injury (AKI) increases, prevention strategies are needed across the healthcare continuum, which begins in the community. Recognizing this knowledge gap, the 22nd Acute Disease Quality Initiative was tasked to discuss the evidence for quality of care measurement and care processes to prevent AKI and its consequences in the community. Using a modified Delphi process, an international and interdisciplinary group provided a framework to identify and monitor patients with AKI in the community.
Source: The American Journal of Medicine - December 10, 2019 Category: General Medicine Authors: Samuel A Silver, Mitra K Nadim, Donal J O'Donoghue, Francis P Wilson, John A Kellum, Ravindra L Mehta, Claudio Ronco, Kianoush Kashani, Mitchell H Rosner, Michael Haase, Andrew JP Lewington Source Type: research

Structure and low energy vibrations in silver borate glasses with low silver content
Publication date: Available online 9 December 2019Source: Journal of Physics and Chemistry of SolidsAuthor(s): Cristina Crupi, Giovanni Carini, Giuseppe Carini, Mauro Federico, Andrea Mandanici, Valentino Romano, Giovanna D'AngeloAbstractStructural changes of (Ag2O)x(B2O3)1-x glasses, over the range between X = 0.0 and X = 0.14, have been monitored by Raman spectroscopy. Low temperature heat capacity measurements have been also performed between 0.4 K and 25 K to investigate along with low frequency Raman scattering the behavior of the low-energy vibrational dynamics. A progressively decreasing intensity of the...
Source: Journal of Physics and Chemistry of Solids - December 9, 2019 Category: Physics Source Type: research

ASAP Controls of Land Use and the River Continuum Concept on Dissolved Organic Matter Composition in an Anthropogenically Disturbed Subtropical Watershed
Environmental Science& TechnologyDOI: 10.1021/acs.est.9b04605
Source: Environmental Science and Technology - December 9, 2019 Category: Environmental Health Authors: managing.editor at (American Chemical Society) Source Type: research

The effectiveness of interventions to involve men living with HIV positive pregnant women in low-income countries: a systematic review of the literature
Male involvement (MI) along the continuum of HIV healthcare services has been promoted as a critical intervention in low-income countries and represents one of the reasons for dropout and low retention of wome...
Source: BMC Health Services Research - December 9, 2019 Category: General Medicine Authors: Isotta Triulzi, Ilaria Palla, Fausto Ciccacci, Stefano Orlando, Leonardo Palombi and Giuseppe Turchetti Tags: Research article Source Type: research

Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
AbstractSpreading depolarization is observed as a large negative shift of the direct current potential, swelling of neuronal somas, and dendritic beading in the brain ’s gray matter and represents a state of a potentially reversible mass injury. Its hallmark is the abrupt, massive ion translocation between intraneuronal and extracellular compartment that causes water uptake (= cytotoxic edema) and massive glutamate release. Dependent on the tissue’s energy st atus, spreading depolarization can co-occur with different depression or silencing patterns of spontaneous activity. In adequately supplied tissue, spreading depo...
Source: AGE - December 9, 2019 Category: Geriatrics Source Type: research

Cardiovascular Disease Risk in Survivors of Breast Cancer
AbstractPurpose of reviewEarly detection and improved treatment in breast cancer have resulted in an increased number of survivors. Cardiovascular disease now remains an important cause for morbidity and mortality in this population. There is a growing gap in the knowledge about the optimal long-term cardiovascular management of this population.FindingsBreast cancer and cardiovascular disease share a number of common risk factors. Different breast cancer treatment modalities, including anthracyclines, radiation, and hormonal therapy, can act in synergy with preexisting and/or new cardiovascular risk factors to result in si...
Source: Current Treatment Options in Cardiovascular Medicine - December 9, 2019 Category: Cardiology Source Type: research

Forgiveness takes place on an attitudinal continuum from hostility to friendliness: Toward a closer union of forgiveness theory and measurement.
Abstract Researchers commonly conceptualize forgiveness as a rich complex of psychological changes involving attitudes, emotions, and behaviors. Psychometric work with the measures developed to capture this conceptual richness, however, often points to a simpler picture of the psychological dimensions in which forgiveness takes place. In an effort to better unite forgiveness theory and measurement, we evaluate several psychometric models for common measures of forgiveness. In doing so, we study people from the United States and Japan to understand forgiveness in both nonclose and close relationships. In addition, ...
Source: Journal of Personality and Social Psychology - December 9, 2019 Category: Psychiatry & Psychology Authors: Forster DE, Billingsley J, Russell VM, McCauley TG, Smith A, Burnette JL, Ohtsubo Y, Schug J, Lieberman D, McCullough ME Tags: J Pers Soc Psychol Source Type: research

'I make sure my doctor doesn't know that I use meth': perceived barriers to pre-exposure prophylaxis (PrEP) uptake among community peer educators in Seattle (WA, USA)
Vanessa M. McMahan, Lauren R. Violette, Michele P. Andrasik, Aleks Martin, Lindsay Garske, Joanne D. Stekler Pre-exposure prophylaxis (PrEP) uptake has been slow among cisgender men and transgender people who have sex with men (MSM/TG) and use methamphetamine, who are disproportionately affected by HIV in the US. Focus groups were conducted with peer educators of a harm reduction organisation in Seattle (WA, USA) to assess knowledge and perspectives regarding PrEP use among MSM/TG who use methamphetamine. Stigma related to the multiple marginalised identities of MSM/TG who use methamphetamine was identified a barrier to ea...
Source: Sexual Health - December 9, 2019 Category: Sexual Medicine Authors: Vanessa M. McMahan Lauren R. Violette Michele P. Andrasik Aleks Martin Lindsay Garske Joanne D. Stekler Source Type: research

Self-Harm, Suicidal Ideation, and Attempted Suicide in Older Adults: A National Study of Emergency Department Visits and Follow-up Care
The risk of suicide increases in later life1 and the U.S. geriatric population is growing rapidly.2 However, relatively few health care initiatives and research studies have focused on suicide prevention in older adults.3 Suicide risk exists on a continuum that varies in severity from thoughts of death or passive suicidal ideation to more severe expressions of suicidal intent, such as active suicidal ideation, preparatory behaviors, and suicide attempts.4 The progression from suicidal thoughts to suicidal behaviors is widely viewed as a critical transition in suicidal intent and risk of death by suicide5 as most individual...
Source: The American Journal of Geriatric Psychiatry - December 9, 2019 Category: Geriatrics Authors: Timothy Schmutte, Mark Olfson, Ming Xie, Steven C. Marcus Tags: Regular Research Article Source Type: research

A Novel Approach to MP-PIC : Continuum Particle Model for Dense Particle Flows in Fluidized Beds
Publication date: Available online 6 December 2019Source: Chemical Engineering ScienceAuthor(s): Vikrant Verma, Johan T. PaddingAbstractA novel approach to Multiphase-Particle-in-Cell (MP-PIC), called Continuum Particle Model (CPM), is developed for dense gas-particle flows. CPM has high computational speed, comparable to that of MP-PIC, but a robustness and accuracy closer to that of a Discrete Element Model (DEM). The gas phase is treated as a continuum phase and particles are tracked discretely, but particle collisions are modelled by considering the divergence of the continuum particle stress tensor. Details on efficie...
Source: Chemical Engineering Science - December 7, 2019 Category: Chemistry Source Type: research

Modulating mechanical anisotropy of two-dimensional materials by controlling their defects
This study should be of great help for providing physical insights into the origins of defect-control isotropy of 2D materials.Graphical abstract
Source: Carbon - December 7, 2019 Category: Materials Science Source Type: research

Designing and Disseminating Metrics to Support Jurisdictional Efforts to End the Public Health Threat Posed by HIV Epidemics.
Abstract The US Department of Health and Human Services has launched a large-scale plan that aims to "End the HIV Epidemic" (EtHE) in America, including ambitious goals and targets over the next 5 to 10 years.To be successful, the EtHE Plan will require timely dissemination of relevant metrics to inform the broad array of stakeholders who are in a position to act in support of the plan's goals. Metrics should include both population health outcome metrics and implementation metrics that track the deployment and uptake of specific intervention delivery strategies. In addition to the usual HIV care continuum metrics...
Source: American Journal of Public Health - December 7, 2019 Category: International Medicine & Public Health Authors: Nash D Tags: Am J Public Health Source Type: research

Leukocyte profiles across the cardiovascular disease continuum a population-based cohort study
Inflammation plays a pivotal role across all stadia of the cardiovascular disease (CVD) continuum, i.e. non-obstructive coronary artery disease (CAD), myocardial infarction (MI), and ischemic heart failure (iHF). However, inflammation across CVD continuum has not been studied yet within one population. Therefore, we mapped leukocyte profiles across the continuum within the UK Biobank.
Source: Journal of Molecular and Cellular Cardiology - December 5, 2019 Category: Cytology Authors: Hilde E. Groot, Irene V. van Blokland, Erik Lipsic, Jacco C. Karper, Pim van der Harst Source Type: research

The PrEP Care Continuum Among Cisgender Women Who Sell Sex and/or Use Drugs Globally: A Systematic Review
AbstractHIV prevalence among cisgender female sex workers (FSW) and/or women who use drugs (WWUD) is substantially higher compared to similarly aged women. Consistent with PRISMA guidelines, we conducted the first systematic review on the pre-exposure prophylaxis (PrEP) continuum among FSW and/or WWUD, searching PubMed, Embase, CINAHL, PsycInfo, and Sociological Abstracts. Eligibility criteria included: reporting a PrEP related result among FSW and/or WWUD aged 18  + ; peer-reviewed; and published in English between 2012 and 2018. Our search identified 1365 studies; 26 met eligibility requirements, across the following g...
Source: AIDS and Behavior - December 5, 2019 Category: Infectious Diseases Source Type: research

“Getting to Zero” Among Men Who Have Sex with Men in China: a Review of the HIV Care Continuum
AbstractPurpose of ReviewTo review the literature on progress towards UNAIDS 90-90-90 targets for HIV prevention and treatment among men who have sex with men (MSM) in China.Recent FindingsChina has made progress towards UNAIDS 90-90-90 targets among MSM. However, socio-structural barriers, including HIV-related stigma and homophobia, persist at each stage of the HIV care continuum, leading to substantial levels of attrition and high risk of forward HIV transmission. Moreover, access to key prevention tools, such as pre-exposure prophylaxis, is still limited. Multilevel interventions, many using digital intervention, have ...
Source: Current HIV/AIDS Reports - December 2, 2019 Category: Infectious Diseases Source Type: research

Interventions to improve the HIV continuum of care in China
AbstractPurpose of ReviewTo describe HIV epidemic and interventions for improving HIV continuum of care in China.Recent FindingsThe reported HIV epidemic has been continuously increasing, partially due to the expansion of active HIV testing campaign. Public health intervention programs have been effective in containing HIV spread among former plasma donors and people who inject drugs (PWID), but more infections occur among heterosexual men and women and young men who have sex with men. Of 1.25 million Chinese people are living with HIV, one-third do not know their status. About two-thirds of diagnosed individuals have used...
Source: Current HIV/AIDS Reports - November 27, 2019 Category: Infectious Diseases Source Type: research

Parsing the pluripotency continuum in humans and non-human primates for interspecies chimera generation.
Abstract Pluripotency refers to the potential of single cells to form all cells and tissues of an organism. The observation that pluripotent stem cells can chimerize the embryos of evolutionarily distant species, albeit at very low efficiencies, could with further modifications, facilitate the production of human-animal interspecies chimeras. The generation of human-animal interspecies chimeras, if achieved, will enable practitioners to recapitulate pathologic human tissue formation in vivo and produce patient-specific organs inside livestock species. However, little is known about the nature of chimera-competent ...
Source: Experimental Cell Research - November 25, 2019 Category: Cytology Authors: De Los Angeles A Tags: Exp Cell Res Source Type: research

A Jail-Based Competency Restoration Unit as a Component of a Continuum of Restoration Services.
This study reports on restoration outcomes of a sample of pretrial defendants (n = 877, 69% male) who were found incompetent to stand trial and underwent restoration services in a large urban county. Each male defendant was initially assigned to restoration in one of four settings on a continuum of services of varying intensity (ie, outpatient, jail general population, dedicated jail-based restoration unit, or forensic hospital inpatient unit) based on the defendant's assessed clinical need. Of those who received services on the jail-based restoration unit (n = 398), 40 percent were restored to competency, 31 percent were ...
Source: Journal of the American Academy of Psychiatry and the Law - November 24, 2019 Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research

Androstadienone resulted in a rightward shift of women's preference for sexually dimorphic male faces across the continuum of femininity-masculinity.
Abstract As a derivative of testosterone, androstadienone (AND) can influence human psychological and physiological states. To explore the influence of AND on women's preferences for male sexual dimorphic faces in a mate-choice context, we asked 52 females in the luteal phase to choose one from four sexual dimorphic male faces in a long-term and short-term context while inhaling 250 μm of AND or a placebo odor on two consecutive days. Results revealed that participants had a greater and lesser preference for the +30% masculinized and 60% feminized faces, respectively, while inhaling AND, as compared to when inh...
Source: Hormones and Behavior - November 22, 2019 Category: Endocrinology Authors: Niu C, Zheng L Tags: Horm Behav Source Type: research

A histological continuum between dentinogenesis imperfecta and dentin dysplasia: A case report with literature review
Nikita Gulati, Saurabh Juneja, Akriti Singh, Iqbal SinghIndian Journal of Dental Research 2019 30(4):643-646 Dentinogenesis Imperfecta and dentin dysplasia are genetic oral diseases inherited in a simple autosomal dominant mode, with high penetrance and a low mutation rate. Both of them are present with bulbous crowns, marked cervical constrictions, severe attritions, few periapical radiolucencies, and premature tooth loss. The diagnosis is based on family history, and detailed clinical examination, while genetic diagnosis may become useful in the future once sufficient disease-causing mutations have been discovered. Here...
Source: Indian Journal of Dental Research - November 18, 2019 Category: Dentistry Authors: Nikita Gulati Saurabh Juneja Akriti Singh Iqbal Singh Source Type: research