Ten-year experience with intracameral chemotherapy for aqueous seeding in retinoblastoma: long-term efficacy, safety and toxicity
Conclusion
ICC appears to be safe and efficient for AS without irreversible vision-threatening adverse effects. More data are needed to determine any superiority in efficiency/toxicity of topotecan versus melphalan. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Stathopoulos, C., Beck-Popovic, M., Moulin, A. P., Munier, F. L. Tags: Open access Oncology Source Type: research
Optical coherence tomography angiography for the characterisation of retinal microvasculature alterations in pregnant patients with anaemia: a nested case-control study
Conclusion
It was found that anaemia during pregnancy was associated with macular microvascular abnormalities, which differed in PA as pregnancy progressed. The results suggest that quantitative OCTA metrics may be useful for risk evaluation before clinical diagnosis.
Trial registration numbers
2021KYPJ098 and ChiCTR2100049850. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Wu, Y., Wang, D., Wu, X., Shen, L., Zhao, L., Wang, W., Xiao, H., Wang, X., Liu, L., Lin, Z., Yang, J., Lin, X., Yun, D., Iao, W. C., Wu, Y., Xu, M., Song, K., Xu, Z., Huang, Y., Shi, S., Zhang, M., Zhou, J., Yang, Z., Wang, Z., Lin, H. Tags: Open access Retina Source Type: research
Predicting 60-4 visual field tests using 3D facial reconstruction
Conclusions
This pilot study reports the development of a CNN-enhanced platform capable of predicting 60–4 visual field defects in healthy controls based on facial contour. Further study with this platform may enhance understanding of the influence of facial contour on 60–4 visual field testing. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Jamali Dogahe, S., Garmany, A., Sadegh Mousavi, S., Khanna, C. L. Tags: Retina Source Type: research
Arterial hypertension and retinal layer thickness: the Beijing Eye Study
Conclusions
Thickness of RNFL, GCL and POS was inversely and INL thickness was positively associated with higher blood pressure, while the thickness of the other retinal layers was not significantly correlated with blood pressure. The findings may be helpful for refinement of the morphometric detection of retinal diseases. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Xie, H., Pan, Z., Xue, C. C., Chen, D., Jonas, J. B., Wu, X., Wang, Y. X. Tags: Retina Source Type: research
Quality assessment of colour fundus and fluorescein angiography images using deep learning
Conclusion
The presented method allows automated IQA in real time, demonstrating human-level performance for CF as well as FA. Such models can help to overcome the problem of human intergrader and intragrader variability by providing objective and reproducible IQA results. It has particular relevance for real-time feedback in multicentre clinical studies, when images are uploaded to central reading centre portals. Moreover, automated IQA as preprocessing step can support integrating automated approaches into clinical practice. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: König, M., Seeböck, P., Gerendas, B. S., Mylonas, G., Winklhofer, R., Dimakopoulou, I., Schmidt-Erfurth, U. M. Tags: Open access Retina Source Type: research
Detection of diabetic neovascularisation using single-capture 65{degrees}-widefield optical coherence tomography angiography
Conclusion
The high reliability of non-invasive WF-OCTA imaging in detecting PDR can improve clinical examination with the potential to replace FA as a single diagnostic tool. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Stino, H., Niederleithner, M., Iby, J., Sedova, A., Schlegl, T., Steiner, I., Sacu, S., Drexler, W., Schmoll, T., Leitgeb, R., Schmidt-Erfurth, U. M., Pollreisz, A. Tags: Open access Retina Source Type: research
Rates of choroidal loss and ganglion cell-inner plexiform layer thinning in type 2 diabetes mellitus and healthy individuals: a 2-year prospective study
Conclusion
Progressive choroidal and GCIPL thinning occurs in healthy individuals and T2DM patients; however, T2DM undergoes accelerated choroidal and GCIPL loss in NPDR patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Hui, Z., Guo, X., Bulloch, G., Yuan, M., Xiong, K., Zhang, S., Chen, Y., Li, Y., Liao, H., Huang, W., Zhu, Z., Wang, W. Tags: Retina Source Type: research
Accuracy of pattern deviation in estimating the glaucomatous damage in the central 10{degrees} visual field in eyes with glaucoma and cataract
Conclusions
This study warns clinicians that PD of the central 10° VF might underestimate the glaucomatous VF damage with the progression of glaucoma and overestimate it as a cataract progresses. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Tomita, R., Asaoka, R., Hirasawa, K., Fujino, Y., Nakakura, S., Murata, H., Omura, T., Shoji, N., Obana, A., Nishiguchi, K. M., Tanito, M. Tags: Glaucoma Source Type: research
Identifying central 10{degrees} visual subfield associated with future worsening of visual acuity in eyes with advanced glaucoma
Conclusion
In advanced glaucoma eyes with well-controlled IOP, careful attention is needed when the mean TD values in the temporal papillomacular bundle VSF, measured with a HFA 10–2 test is deteriorated. TD values of this VSF indicate higher risks for future deterioration of VA and also blindness. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Asaoka, R., Sugisaki, K., Inoue, T., Yoshikawa, K., Kanamori, A., Yamazaki, Y., Ishikawa, S., Uchida, K., Iwase, A., Araie, M., For Advanced Glaucoma Study Members in Japan Glaucoma Society, for Advanced Glaucoma Study Members in Japan Glaucoma Society, A Tags: Glaucoma Source Type: research
Use of ultrasound biomicroscopy to predict the outcome of anterior segment reconstruction in congenital fibrovascular pupillary membrane with secondary glaucoma
Conclusions
ASR for CFPMSG results in increased ACD and improvement in IOP. Postoperative IOP control was best in type CFPMSG but not as effective in types and . UBM-based classification helps to predict the surgical outcome of ASR in CFPMSG. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Zhu, Y., Fang, L., Oatts, J., Han, Y., Lin, S., Chen, L., Liu, X., Zhong, Y. Tags: Open access Glaucoma Source Type: research
Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021
Conclusion
Risk factors for BRI after trabeculectomy include wound manipulation, high myopia and hyperlipidaemia. Considering myopia is highly prevalent throughout the world and is a risk factor for glaucoma, the lifelong risk of BRI after trabeculectomy in eyes with high myopia warrants the attention of ophthalmologists. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Yang, H.-Y., Chi, S.-C., Ko, Y.-C., Chen, M.-J., Kuang, T.-M., Chang, Y.-F., Liu, C. J.-L. Tags: Glaucoma Source Type: research
Smoking, dietary factors and major age-related eye disorders: an umbrella review of systematic reviews and meta-analyses
Conclusions
Smoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review.
PROSPERO registration number
CRD42022339082. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Kai, J.-Y., Zhou, M., Li, D.-L., Zhu, K.-Y., Wu, Q., Zhang, X.-F., Pan, C.-W. Tags: Lens and cataract Source Type: research
Actual lens positions of three intraocular lenses in highly myopic eyes: an ultrasound biomicroscopy-based study
Conclusion
In highly myopic eyes, IOLs with good capsular support show less backward bending, which result in a more stable lens position and refractive status postoperatively. Severe capsular contraction and low implanted power are risk factors for bending of certain IOLs. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Qi, J., He, W., Zhang, K., Guo, D., Du, Y., Lu, Y., Zhu, X. Tags: Lens and cataract Source Type: research
Biological effects of stored platelet-rich plasma eye-drops in corneal wound healing
Conclusion
PRP eye-drops stored at 4°C for 4 weeks promoted corneal epithelial wound healing with higher levels of growth factors than those observed in AS eye-drops, while maintaining sterility, suggesting that this preparation satisfies the unmet medical needs in the treatment of refractory keratoconjunctival epithelial disorders. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Okumura, Y., Inomata, T., Fujimoto, K., Fujio, K., Zhu, J., Yanagawa, A., Shokirova, H., Saita, Y., Kobayashi, Y., Nagao, M., Nishio, H., Sung, J., Midorikawa-Inomata, A., Eguchi, A., Nagino, K., Akasaki, Y., Hirosawa, K., Huang, T., Kuwahara, M., Murakam Tags: Cornea and ocular surface Source Type: research
Early ocular surface and tear film status in congenital aniridia indicates a supportive treatment window
Conclusions
Ocular surface damage and dry eye signs appear in congenital aniridia regardless of mutation, appearing after 10 years of age and progressing thereafter. An early treatment window may exist for therapies to protect the ocular surface homoeostasis and limbal function, to possibly delay keratopathy development and progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Fries, F. N., Moslemani, K., Utheim, T. P., Seitz, B., Käsmann-Kellner, B., Lagali, N. S. Tags: Open access Cornea and ocular surface Source Type: research
