Ensemble of deep convolutional neural networks is more accurate and reliable than board-certified ophthalmologists at detecting multiple diseases in retinal fundus photographs
Discussion
We developed a deep learning model and found that it could more accurately and reliably classify four categories of fundus images compared with board-certified ophthalmologists. This work provides proof-of-principle that an algorithm is capable of accurate and reliable recognition of multiple retinal diseases using only fundus photographs. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Pandey, P. U., Ballios, B. G., Christakis, P. G., Kaplan, A. J., Mathew, D. J., Ong Tone, S., Wan, M. J., Micieli, J. A., Wong, J. C. Y. Tags: Open access Retina Source Type: research
Pathologic myopia in highly myopic patients with high axial anisomyopia
Conclusions
Even when controlled for AL, PM complications in the LAE predict similar PM complications in the SAE. Patients with high axial anisometropia with PM in the LAE should be monitored carefully for complications in the SAE. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Li, J., Dan, Y. S., Chua, S. Q., Wong, Q. Y., Chong, R. S., Ang, M., SNEC Retina Group, Wong, C. W., Hoang, Q. V., SNEC Retina Group, Ang, Chan, Cheung, Cheung, Fenner, Lee, Mathur, Sim, Rim, Tan, Tan, Teo, Ting, Tsai, Wiryasaputra, Wong, Wong, Yeo Tags: Retina Source Type: research
Sympathetic nervous system activity is associated with choroidal thickness and axial length in school-aged children
Conclusions
We hypothesised that chronic stress characterised by elevated level of the SNS, was associated with significant increase in AL elongation, probably through thinning of the choroid. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Lin, S., Zhu, B., Wang, T., Wang, H., Xu, X., Wang, S., Yin, Y., Xiang, Z., Qian, Y., Zhang, Z., Cui, L., Zou, H., He, X., Zhu, J., Ma, Y. Tags: Open access Retina Source Type: research
Acute posterior multifocal placoid pigment epitheliopathy: clinical presentation and risk of stroke and transient ischaemic attack
Conclusions
The presence of headache cannot reliably predict those at risk of stroke/TIA. Individuals presenting with acute posterior multifocal pigment epitheliopathy should therefore undergo a clinical neurological review and work-up for cerebral vasculitis as deemed appropriate by the treating ophthalmologist and collaborating neurologist. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Niederer, R. L., Samalia, P. D., Chen, Y.-H., Goh, J. K., Cornish, E. E., Guest, S., McCluskey, P. J., Lim, L. L., Sims, J. L., Lightman, S., Tomkins-Netzer, O. Tags: Retina Source Type: research
Incidence and multimodal imaging characteristics of macular neovascularisation subtypes in Chinese neovascular age-related macular degeneration patients
Conclusion
Based on the consensus anatomical classification system developed by the CONAN Study Group, we updated the incidence of MNV subtypes and found that PCV was the most common subtype and type 3 MNV was the least common subtype among Chinese nAMD patients. In addition, the co-occurrence of PCV and type 2 MNV was typically observed, and its frequency was reported in our study. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Zhang, Y., Gan, Y., Zeng, Y., Zhuang, X., Zhang, X., Ji, Y., Su, Y., Wen, F. Tags: Retina Source Type: research
Assessment of choriocapillaris and choroidal vascular changes in posterior uveitis using swept-source wide-field optical coherence tomography angiography
Conclusion
CC and choroidal assessment using OCTA provides useful information in patients with posterior uveitis. SS-OCTA metrics of the CC and choroidal slabs are promising tools in uveitis patients in the future.
Trial registration number
NCT02811536. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Tian, M., Zeng, G., Zinkernagel, M., Tappeiner, C., Wolf, S., Munk, M. R. Tags: Uveitis Source Type: research
Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease
Conclusions
Our results suggest that adult and paediatric eyes with uveitis typically have improved VA following cataract surgery and remain stable thereafter for at least 5 years. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Gangaputra, S., Newcomb, C., Armour, R., Choi, D., Ying, G.-s., Groth, S., Begum, H., Fitzgerald, T., Artornsombudh, P., Daniel, E., Bhatt, N., Foster, S., Jabs, D., Levy-Clarke, G., Nussenblatt, R., Rosenbaum, J. T., Sen, H. N., Suhler, E., Thorne, J., D Tags: Uveitis Source Type: research
Central visual field damage in glaucoma eyes with choroidal microvasculature dropout with and without high axial myopia
Conclusions
MvD was more prevalent and larger in POAG eyes with high myopia than in non-highly myopic POAG eyes. In both groups, eyes with MvD showed worse glaucoma severity and more central VF defects. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Micheletti, E., El-Nimri, N., Nishida, T., Moghimi, S., Rezapour, J., Fazio, M. A., Suh, M. H., Bowd, C., Belghith, A., Christopher, M., Jonas, J. B., Weinreb, R. N., Zangwill, L. M. Tags: Glaucoma Source Type: research
Iris volume change with physiologic mydriasis to identify development of angle closure: the Zhongshan Angle Closure Prevention Trial
Conclusion
A smaller change in VOL is an additive risk factor to identify eyes more likely to develop angle closure disease.
Trial registration number
ISRCTN45213099. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Liao, C., Quigley, H., Jiang, Y., Huang, S., Huang, W., Friedman, D., Foster, P. J., He, M. Tags: Glaucoma Source Type: research
Influence of choroidal microvasculature dropout on progressive retinal nerve fibre layer thinning in primary open-angle glaucoma: comparison of parapapillary {beta}-zones and {gamma}-zones
Conclusions
The presence of cMvD was significantly associated with a faster rate of RNFL thinning in POAG eyes with β-zone, but not -zone. The pathogenic consequences of cMvD in POAG eyes may depend on accompanying peripapillary structures. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Hwang, H. S., Lee, E. J., Kim, J.-A., Lee, S. H., Kim, T.-W. Tags: Glaucoma Source Type: research
Differentiating stages of functional vision loss from glaucoma using the Disc Damage Likelihood Scale and cup:disc ratio
Conclusion
This study indicates that both structural staging systems can differentiate severe/end-stage glaucoma from less severe disease, with a moderate advantage of DDLS over CDR. Clinical examination of the optic disc plays an important role in addition to functional assessment when managing severe/end-stage glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Philippin, H., Matayan, E. N., Knoll, K. M., Macha, E., Mbishi, S., Makupa, A., Matsinhe, C. D., da Gama, I. V., Monjane, M. J., Ncheda, J. A., Mulobuana, F. A. F., Muna, E., Guylene, N. F., Gazzard, G., Marques, A. P., Shah, P., Macleod, D., Makupa, W., Tags: Open access Glaucoma Source Type: research
Collagen type XII is undetectable in keratoconus Bowmans layer
Conclusions
The apparent absence of COL12A1 in KC BL, together with the functional importance that COL12A1 is thought to have in stress bearing areas, suggests that COL12A1 may play a role in the pathogenesis of KC. Further studies are necessary to investigate the mechanisms that lead to COL12A1 dysregulation in KC. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Rigi, M., Son, H.-S., Moon, L., Matthaei, M., Srikumaran, D., Jun, A. S., Eberhart, C. G., Soiberman, U. S. Tags: Cornea and ocular surface Source Type: research
Accurate detection and grading of pterygium through smartphone by a fusion training model
Conclusion
Our fusion model method got high pterygium detection and grading accuracy in insufficient smartphone data, and its performance is comparable to experienced ophthalmologists and works well in different smartphone brands. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Liu, Y., Xu, C., Wang, S., Chen, Y., Lin, X., Guo, S., Liu, Z., Wang, Y., Zhang, H., Guo, Y., Huang, C., Wu, H., Li, Y., Chen, Q., Hu, J., Luo, Z., Liu, Z. Tags: Open access Cornea and ocular surface Source Type: research
New insights on the role of microRNAs in retinal Müller glial cell function
MicroRNAs belong to the family of non-coding RNAs that participate in cell proliferation, cell death and development. The Müller glial cells are the inherent and specific neuroglia cells in the retinal organisation and play significant roles in retinal neuroprotection, organisational maintenance, inflammation and immunity, regeneration, and the occurrence and development of retinal diseases. However, only a few studies report the underlying mechanism of how miRNAs drive the function of Müller glial cells in the development of retinal diseases. This review aims to summarise the roles of miRNAs in retinal Mu&...
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Jiang, W., He, S., Liu, L., Meng, X., Lu, J., Li, J., Chen, T., Xu, Y., Xiao, Q., Qi, L., Zhang, J. Tags: Open access Retina Source Type: research
At a glance
Accurate detection and grading of pterygium through smartphone by a fusion training model (see page 336) The authors' fusion model method works as a helpful tool for improving pterygium detection and grading accuracy in the context of insufficient smartphone data in the absence of a mobile mature database. Collagen type XII is undetectable in keratoconus Bowman’s layer (see page 343) Collagen type XII, a regulator of corneal form and stability, is undetectable in Bowman’s layer of keratoconic corneas, suggesting a possible integral role in the pathogenesis of keratoconus. Differentiating stages of functional vi...
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Larkin, F. Tags: Highlights from this issue Source Type: research
