Global untargeted and individual targeted plasma metabolomics of breast cancer recurrence modified by hormone receptors
CONCLUSION: Our study revealed that plasma metabolites were significantly different between recurrent and non-recurrent patients, proposing therapeutic insights for breast cancer prognosis.PMID:38652345 | DOI:10.1007/s12282-024-01579-1 (Source: Breast Cancer)
Source: Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Pei-Jing Yang Eing-Mei Tsai Ming-Feng Hou Yen-Jung Lee Tsu-Nai Wang Source Type: research
Number of lines of previous chemotherapy regimen might affect the oucome of sacituzumab govitecan in metastatic triple-negative breast cancer patients
Breast Cancer. 2024 Apr 22. doi: 10.1007/s12282-024-01587-1. Online ahead of print.NO ABSTRACTPMID:38647866 | DOI:10.1007/s12282-024-01587-1 (Source: Breast Cancer)
Source: Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Kadri Altundag Source Type: research
Perspectives for the clinical application of ctDNA analysis to breast cancer drug therapy
Breast Cancer. 2024 Apr 23. doi: 10.1007/s12282-024-01571-9. Online ahead of print.ABSTRACTCirculating tumor DNA (ctDNA) consists of DNA fragments released from cancer cells into the blood circulation with quick clearance. Analysis of ctDNA can enable real-time assessment of the presence of cancer cells and their genomic characteristics. Therefore, ctDNA is expected to be one of the most useful biomarkers for cancer. In recent years, several ultra-sensitive assays for ctDNA analysis have been developed, and many clinical trials are using these assays to investigate the efficacy of ctDNA-based therapeutic strategies. In the...
Source: Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Yoshinami Source Type: research
Concordance of HER2 status between core needle biopsy and surgical resection specimens of breast cancer: an analysis focusing on the HER2-low status
CONCLUSIONS: Incorporation of HER2-low category in HER2 status interpretation reduces the concordance rate between CNB and surgical resection specimens. Tumor multiplicity and ER positivity are predictive factors for conversion from HER2-zero to HER2-low status. Therefore, HER2 status should be re-evaluated in resection specimens when considering ADCs in tumors exhibiting multiplicity and ER positivity.PMID:38643429 | DOI:10.1007/s12282-024-01585-3 (Source: Breast Cancer)
Source: Breast Cancer - April 21, 2024 Category: Cancer & Oncology Authors: Sei Na Milim Kim Yujun Park Hyun Jung Kwon Hee-Chul Shin Eun-Kyu Kim Mijung Jang Sun Mi Kim So Yeon Park Source Type: research
Comparing survival outcomes between neoadjuvant and adjuvant chemotherapy within T2N1M0 stage hormone receptor-positive, HER2-negative breast cancer: a retrospective cohort study based on SEER database
CONCLUSION: Among T2N1M0 stage HR + /HER2- patients, OS and BCSS of NACT were inferior to ACT. Patients who attained non-pCR after NACT demonstrated significantly worse survival outcomes compared with those who received ACT.PMID:38643430 | DOI:10.1007/s12282-024-01583-5 (Source: Breast Cancer)
Source: Breast Cancer - April 21, 2024 Category: Cancer & Oncology Authors: Yuhang Shang Xuelian Wang Yansong Liu Weilun Cheng Yunqiang Duan Zhengbo Fang Jiangwei Liu Fanjing Kong Ting Wang Tianshui Yu Anbang Hu Jiarui Zhang Hanyu Zhang Mingcui Li Zhiyuan Rong Yanling Li Suborna S Shakila Xinxin Li Jianyuan Feng Fei Ma Baoliang G Source Type: research
Real-world progression-free survival and overall survival of palbociclib plus endocrine therapy (ET) in Japanese patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer in the first-line or second-line setting: an observational study
CONCLUSION: The addition of palbociclib to ET was effective for treating HR+/HER2- ABC in Japanese routine clinical practice.PMID:38642245 | DOI:10.1007/s12282-024-01575-5 (Source: Breast Cancer)
Source: Breast Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Yoshinami Shigenori E Nagai Masaya Hattori Takuho Okamura Kenichi Watanabe Takahiro Nakayama Hiroko Masuda Michiko Tsuneizumi Daisuke Takabatake Michiko Harao Hiroshi Yoshino Natsuko Mori Hiroyuki Yasojima Chiya Oshiro Madoka Iwase Miki Yamaguch Source Type: research
French national survey on breast cancer care: caregiver and patient views
CONCLUSIONS: This study provides an updated analysis of breast cancer care pathways in France. Overall, the initial processes of diagnosis, announcement, and treatment were swift and were in agreement with the best care standards. No barriers to accessing care were identified. Based on the study findings, we proposed several strategies to improve the quality of care for patients in supportive care, coordination with primary care physicians, reconstructive surgery, and fertility preservation access.PMID:38635135 | DOI:10.1007/s12282-024-01576-4 (Source: Breast Cancer)
Source: Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Christine Rousset-Jablonski Barbara Lortal Sophie Lantheaume Laurent Arnould H élène Simon Anne-Sophie Tuszynski M élanie Courtier Soukayna Debbah Marc Lefran çois Sita Balbin Anne-Sophie Kably Alain Toledano Source Type: research
French national survey on breast cancer care: caregiver and patient views
CONCLUSIONS: This study provides an updated analysis of breast cancer care pathways in France. Overall, the initial processes of diagnosis, announcement, and treatment were swift and were in agreement with the best care standards. No barriers to accessing care were identified. Based on the study findings, we proposed several strategies to improve the quality of care for patients in supportive care, coordination with primary care physicians, reconstructive surgery, and fertility preservation access.PMID:38635135 | DOI:10.1007/s12282-024-01576-4 (Source: Breast Cancer)
Source: Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Christine Rousset-Jablonski Barbara Lortal Sophie Lantheaume Laurent Arnould H élène Simon Anne-Sophie Tuszynski M élanie Courtier Soukayna Debbah Marc Lefran çois Sita Balbin Anne-Sophie Kably Alain Toledano Source Type: research
PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer
Breast Cancer. 2024 Apr 17. doi: 10.1007/s12282-024-01567-5. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It has higher aggressiveness and metastasis than other subtypes, with limited effective therapeutic strategies, leading to a poor prognosis. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) gro...
Source: Breast Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Huan-Ping Zhang Rui-Yuan Jiang Jia-Yu Zhu Ke-Na Sun Yuan Huang Huan-Huan Zhou Ya-Bing Zheng Xiao-Jia Wang Source Type: research
PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer
Breast Cancer. 2024 Apr 17. doi: 10.1007/s12282-024-01567-5. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It has higher aggressiveness and metastasis than other subtypes, with limited effective therapeutic strategies, leading to a poor prognosis. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) gro...
Source: Breast Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Huan-Ping Zhang Rui-Yuan Jiang Jia-Yu Zhu Ke-Na Sun Yuan Huang Huan-Huan Zhou Ya-Bing Zheng Xiao-Jia Wang Source Type: research
The usefulness of artificial intelligence in breast reconstruction: a systematic review
CONCLUSIONS: In breast reconstruction, AI can help the surgeon by optimizing the perioperative patients' counseling to predict negative outcomes, allowing execution of timely interventions and reducing the postoperative burden, which leads to obtaining the most successful results and improving patient satisfaction.PMID:38619786 | DOI:10.1007/s12282-024-01582-6 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Karla C Maita Francisco R Avila Ricardo A Torres-Guzman John P Garcia Gioacchino D De Sario Velasquez Sahar Borna Sally A Brown Clifton R Haider Olivia S Ho Antonio Jorge Forte Source Type: research
Inter- and intra-observer variability of qualitative visual breast-composition assessment in mammography among Japanese physicians: a first multi-institutional observer performance study in Japan
CONCLUSIONS: Qualitative visual assessment of mammographic breast composition using the new Japanese classification revealed excellent intra-observer reproducibility. However, persistent inter-observer variability, presenting a challenge in establishing it as the gold standard in Japan.PMID:38619787 | DOI:10.1007/s12282-024-01580-8 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yoichi Koyama Kazuaki Nakashima Shunichiro Orihara Hiroko Tsunoda Fuyo Kimura Natsuki Uenaka Kanako Ban Yukiko Michishita Yoshihide Kanemaki Arisa Kurihara Kanae Tawaraya Masataka Taguri Takashi Ishikawa Takayoshi Uematsu Source Type: research
The usefulness of artificial intelligence in breast reconstruction: a systematic review
CONCLUSIONS: In breast reconstruction, AI can help the surgeon by optimizing the perioperative patients' counseling to predict negative outcomes, allowing execution of timely interventions and reducing the postoperative burden, which leads to obtaining the most successful results and improving patient satisfaction.PMID:38619786 | DOI:10.1007/s12282-024-01582-6 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Karla C Maita Francisco R Avila Ricardo A Torres-Guzman John P Garcia Gioacchino D De Sario Velasquez Sahar Borna Sally A Brown Clifton R Haider Olivia S Ho Antonio Jorge Forte Source Type: research
Inter- and intra-observer variability of qualitative visual breast-composition assessment in mammography among Japanese physicians: a first multi-institutional observer performance study in Japan
CONCLUSIONS: Qualitative visual assessment of mammographic breast composition using the new Japanese classification revealed excellent intra-observer reproducibility. However, persistent inter-observer variability, presenting a challenge in establishing it as the gold standard in Japan.PMID:38619787 | DOI:10.1007/s12282-024-01580-8 (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yoichi Koyama Kazuaki Nakashima Shunichiro Orihara Hiroko Tsunoda Fuyo Kimura Natsuki Uenaka Kanako Ban Yukiko Michishita Yoshihide Kanemaki Arisa Kurihara Kanae Tawaraya Masataka Taguri Takashi Ishikawa Takayoshi Uematsu Source Type: research
Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study
CONCLUSIONS: Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.PMID:38607499 | DOI:10.1007/s12282-024-01577-3 (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Peter J K Tokuda Takamasa Mitsuyoshi Yuka Ono Takahiro Kishi Yoshiharu Negoro Setsuko Okumura Itaru Ikeda Takashi Sakamoto Yumi Kokubo Ryo Ashida Toshiyuki Imagumbai Mikiko Yamashita Hiroaki Tanabe Sayaka Takebe Mariko Tokiwa Eiji Suzuki Chikako Yamauchi Source Type: research
