Abnormal functional connectivity of white-matter networks and gray-white matter functional networks in patients with NMOSD
Brain Res Bull. 2024 Apr 12:110949. doi: 10.1016/j.brainresbull.2024.110949. Online ahead of print.ABSTRACTCognitive impairment (CI) has been reported in 29-70% of patients with neuromyelitis optica spectrum disorder (NMOSD). Abnormal white matter (WM) functional networks that correlate with cognitive functions have not been studied well in patients with NMOSD. The aim of the current study was to investigate functional connectivity (FC), spontaneous activity, and functional covariance connectivity (FCC) abnormalities of WM functional networks in patients with NMOSD and their correlation with cognitive performance. Twenty-f...
Source: Brain Research Bulletin - April 14, 2024 Category: Neurology Authors: Xincui Wan Yingjie Tang Yu Wu Zhenming Xu Wangsheng Chen Feng Chen Cheng Luo Fei Wang Source Type: research
Abnormal functional connectivity of white-matter networks and gray-white matter functional networks in patients with NMOSD
Brain Res Bull. 2024 Apr 12:110949. doi: 10.1016/j.brainresbull.2024.110949. Online ahead of print.ABSTRACTCognitive impairment (CI) has been reported in 29-70% of patients with neuromyelitis optica spectrum disorder (NMOSD). Abnormal white matter (WM) functional networks that correlate with cognitive functions have not been studied well in patients with NMOSD. The aim of the current study was to investigate functional connectivity (FC), spontaneous activity, and functional covariance connectivity (FCC) abnormalities of WM functional networks in patients with NMOSD and their correlation with cognitive performance. Twenty-f...
Source: Brain Research Bulletin - April 14, 2024 Category: Neurology Authors: Xincui Wan Yingjie Tang Yu Wu Zhenming Xu Wangsheng Chen Feng Chen Cheng Luo Fei Wang Source Type: research
Mesenchymal Stem Cell-Derived Exosomes Overexpressing SRC-3 Protect Mice from Cerebral Ischemia by Inhibiting Ferroptosis
CONCLUSIONS: Our results suggest that MSC-derived exosomes expressing SRC3 can be a therapeutic strategy for cerebral ischemia by inhibiting ferroptosis.PMID:38614406 | DOI:10.1016/j.brainresbull.2024.110948 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Mingyang Deng Ying Hou Jianyang Liu Jialin He Ziwei Lan Han Xiao Source Type: research
Brain morphological changes and functional neuroanatomy related to cognitive and emotional distractors during working memory maintenance in post-traumatic stress disorder
This study evaluated the differential brain activation patterns associated with cognitive and emotional distractors during working memory (WM) maintenance for human faces between patients with PTSD and healthy controls (HCs) and assessed the relationship between changes in the activation patterns by the opposing effects of distraction types and gray matter volume (GMV). Twenty-two patients with PTSD and twenty-two HCs underwent T1-weighted magnetic resonance imaging (MRI) and event-related functional MRI (fMRI), respectively. Event-related fMRI data were recorded while subjects performed a delayed-response WM task with hum...
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Gwang-Won Kim Jong-Il Park Jong-Chul Yang Source Type: research
Combining fecal 16 S rRNA sequencing and spinal cord metabolomics analysis to explain the modulatory effect of PPARα on neuropathic pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
Causal Interactions in Brain Networks Predict Pain Levels in Trigeminal Neuralgia
Brain Res Bull. 2024 Apr 11:110947. doi: 10.1016/j.brainresbull.2024.110947. Online ahead of print.ABSTRACTTrigeminal neuralgia (TN) is a highly debilitating facial pain condition. Magnetic resonance imaging (MRI) is the main method for generating insights into the central mechanisms of TN pain in humans. Studies have found both structural and functional abnormalities in various brain structures in TN patients as compared with healthy controls. Whereas studies have also examined aberrations in brain networks in TN, no studies have to date investigated causal interactions in these brain networks and related these causal int...
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Yun Liang Qing Zhao John K Neubert Mingzhou Ding Source Type: research
Mesenchymal Stem Cell-Derived Exosomes Overexpressing SRC-3 Protect Mice from Cerebral Ischemia by Inhibiting Ferroptosis
CONCLUSIONS: Our results suggest that MSC-derived exosomes expressing SRC3 can be a therapeutic strategy for cerebral ischemia by inhibiting ferroptosis.PMID:38614406 | DOI:10.1016/j.brainresbull.2024.110948 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Mingyang Deng Ying Hou Jianyang Liu Jialin He Ziwei Lan Han Xiao Source Type: research
Brain morphological changes and functional neuroanatomy related to cognitive and emotional distractors during working memory maintenance in post-traumatic stress disorder
This study evaluated the differential brain activation patterns associated with cognitive and emotional distractors during working memory (WM) maintenance for human faces between patients with PTSD and healthy controls (HCs) and assessed the relationship between changes in the activation patterns by the opposing effects of distraction types and gray matter volume (GMV). Twenty-two patients with PTSD and twenty-two HCs underwent T1-weighted magnetic resonance imaging (MRI) and event-related functional MRI (fMRI), respectively. Event-related fMRI data were recorded while subjects performed a delayed-response WM task with hum...
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Gwang-Won Kim Jong-Il Park Jong-Chul Yang Source Type: research
Causal Interactions in Brain Networks Predict Pain Levels in Trigeminal Neuralgia
Brain Res Bull. 2024 Apr 11:110947. doi: 10.1016/j.brainresbull.2024.110947. Online ahead of print.ABSTRACTTrigeminal neuralgia (TN) is a highly debilitating facial pain condition. Magnetic resonance imaging (MRI) is the main method for generating insights into the central mechanisms of TN pain in humans. Studies have found both structural and functional abnormalities in various brain structures in TN patients as compared with healthy controls. Whereas studies have also examined aberrations in brain networks in TN, no studies have to date investigated causal interactions in these brain networks and related these causal int...
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Yun Liang Qing Zhao John K Neubert Mingzhou Ding Source Type: research
Combining Fecal 16S rRNA Sequencing and Spinal Cord Metabolomics analysis to explain the modulatory effect of PPAR α on Neuropathic Pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1
Brain Res Bull. 2024 Apr 10;211:110945. doi: 10.1016/j.brainresbull.2024.110945. Online ahead of print.ABSTRACTSleep fragmentation (SF) is a common sleep problem experienced during the perioperative period by older adults, and is associated with postoperative cognitive dysfunction (POCD). Increasing evidence indicates that delta-wave activity during non-rapid eye movement (NREM) sleep is involved in sleep-dependent memory consolidation and that hippocampal theta oscillations are related to spatial exploratory memory. Recovery sleep (RS), a self-regulated state of sleep homeostasis, enhances delta-wave power and memory perf...
Source: Brain Research Bulletin - April 12, 2024 Category: Neurology Authors: Yun Li Shaowei Hou Feixiang Li Siwen Long Yue Yang Yize Li Lina Zhao Yonghao Yu Source Type: research
Isobavachalcone alleviates ischemic stroke by suppressing HDAC1 expression and improving M2 polarization
In this study, we evaluated the influence of ISO in both transient middle cerebral artery occlusion/reperfusion (tMCAO/R) rat models and oxygen-glucose deprivation/reperfusion (OGD/R) cell models. We observed that pretreatment with 50 mg/kg ISO diminished the volume of brain infarction, reduced brain edema, and ameliorated neurological deficits in rats. A reduction in Nissl bodies was noted in the tMCAO/R group, which was reversed following treatment with 50 mg/kg ISO. TUNEL/NeuN double staining revealed a decrease in TUNEL-positive cells in tMCAO/R rats treated with ISO. Furthermore, ISO treatment suppressed the expressio...
Source: Brain Research Bulletin - April 11, 2024 Category: Neurology Authors: Qiannan Zhang Junting Dai Yongzhong Lin Miao Li Source Type: research
Isobavachalcone alleviates ischemic stroke by suppressing HDAC1 expression and improving M2 polarization
In this study, we evaluated the influence of ISO in both transient middle cerebral artery occlusion/reperfusion (tMCAO/R) rat models and oxygen-glucose deprivation/reperfusion (OGD/R) cell models. We observed that pretreatment with 50mg/kg ISO diminished the volume of brain infarction, reduced brain edema, and ameliorated neurological deficits in rats. A reduction in Nissl bodies was noted in the tMCAO/R group, which was reversed following treatment with 50mg/kg ISO. TUNEL/NeuN double staining revealed a decrease in TUNEL-positive cells in tMCAO/R rats treated with ISO. Furthermore, ISO treatment suppressed the expression ...
Source: Brain Research Bulletin - April 11, 2024 Category: Neurology Authors: Qiannan Zhang Junting Dai Yongzhong Lin L I Miao Source Type: research
Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
