Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Brain Behav Immun. 2024 Apr 10;119:286-300. doi: 10.1016/j.bbi.2024.04.009. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive neurological disorder causing memory loss and cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration remain unclear, leading to a lack of effective strategies to prevent dementia. Recent evidence highlights the role of neuroinflammation, particularly involving microglia, in Alzheimer's disease onset and progression. Characterizing the initial phase of Alzheimer's disease can lead to the discovery of new biomarkers and therapeutic targets, facilitat...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Giusy Pizzirusso Efthalia Preka Julen Goikolea Celia Aguilar-Ruiz Patricia Rodriguez-Rodriguez Guillermo Vazquez-Cabrera Simona Laterza Maria Latorre-Leal Francesca Eroli Klas Blomgren Silvia Maioli Per Nilsson Adamantia Fragkopoulou Andr é Fisahn Luis E Source Type: research
Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring
Brain Behav Immun. 2024 Apr 10;119:301-316. doi: 10.1016/j.bbi.2024.04.010. Online ahead of print.ABSTRACTMaternal obesity is associated with an increased risk of psychiatric disorders such as anxiety, depression, schizophrenia and autism spectrum disorder in the offspring. While numerous studies focus on preventive measures targeting the mothers, only a limited number provide practical approaches for addressing the damages once they are already established. We have recently demonstrated the interplay between maternal obesity and treatment with cannabidiol (CBD) on hypothalamic inflammation and metabolic disturbances, howe...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Fernanda da Silva Rodrigues Jeferson Jantsch Gabriel de Farias Fraga Vit ória Luiza de Camargo Milczarski Victor Silva Dias Camila Scheid Josias de Oliveira Merib Marcia Giovernardi Renata Padilha Guedes Source Type: research
Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy
In conclusion, gut-related alterations reflecting a dysfunctional state, occur during epilepsy development in a TLE mouse model. A short-term treatment with rifaximin during the early phase of the disease, reduced seizure duration and neuropathology, and reversed some intestinal changes, strengthening the therapeutic effects of gut-based therapies in epilepsy.PMID:38608741 | DOI:10.1016/j.bbi.2024.04.007 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Valentina Kebede Teresa Ravizza Silvia Balosso Rossella Di Sapia Luca Canali Sara Soldi Serena Galletti Christina Papazlatani Panagiotis A Karas Sotirios Vasileiadis Annalisa Sforzini Laura Pasetto Valentina Bonetto Annamaria Vezzani Loredana Vesci Source Type: research
Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis
We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to asse...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Mattia Campana Vladislav Yakimov Joanna Moussiopoulou Isabel Maurus Lisa L öhrs Florian Raabe Iris J äger Matin Mortazavi Michael E Benros Rose Jeppesen Gerd Meyer Zu H örste Michael Heming Eloi Gin é-Servén Javier Labad Ester Boix Belinda Lennox Kse Source Type: research
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii
Brain Behav Immun. 2024 Apr 10:S0889-1591(24)00353-2. doi: 10.1016/j.bbi.2024.04.008. Online ahead of print.ABSTRACTChronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive deficits. We found that T. gondii infection induced cognitive deficits in mice, which was characterized by synaptic ultrastructure impairment and neuroinflammation in the hippocampus. Moreover, the infection led to g...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Xiaoying Yang Yuying Zhou Shimin Tan Xiaokang Tian Xianran Meng Yiling Li Beibei Zhou Guihua Zhao Xing Ge Cheng He Wanpeng Cheng Yumei Zhang Kuiyang Zheng Kun Yin Yinghua Yu Wei Pan Source Type: research
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Brain Behav Immun. 2024 Apr 10;119:286-300. doi: 10.1016/j.bbi.2024.04.009. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive neurological disorder causing memory loss and cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration remain unclear, leading to a lack of effective strategies to prevent dementia. Recent evidence highlights the role of neuroinflammation, particularly involving microglia, in Alzheimer's disease onset and progression. Characterizing the initial phase of Alzheimer's disease can lead to the discovery of new biomarkers and therapeutic targets, facilitat...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Giusy Pizzirusso Efthalia Preka Julen Goikolea Celia Aguilar-Ruiz Patricia Rodriguez-Rodriguez Guillermo Vazquez-Cabrera Simona Laterza Maria Latorre-Leal Francesca Eroli Klas Blomgren Silvia Maioli Per Nilsson Adamantia Fragkopoulou Andr é Fisahn Luis E Source Type: research
Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring
Brain Behav Immun. 2024 Apr 10;119:301-316. doi: 10.1016/j.bbi.2024.04.010. Online ahead of print.ABSTRACTMaternal obesity is associated with an increased risk of psychiatric disorders such as anxiety, depression, schizophrenia and autism spectrum disorder in the offspring. While numerous studies focus on preventive measures targeting the mothers, only a limited number provide practical approaches for addressing the damages once they are already established. We have recently demonstrated the interplay between maternal obesity and treatment with cannabidiol (CBD) on hypothalamic inflammation and metabolic disturbances, howe...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Fernanda da Silva Rodrigues Jeferson Jantsch Gabriel de Farias Fraga Vit ória Luiza de Camargo Milczarski Victor Silva Dias Camila Scheid Josias de Oliveira Merib Marcia Giovernardi Renata Padilha Guedes Source Type: research
Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy
In conclusion, gut-related alterations reflecting a dysfunctional state, occur during epilepsy development in a TLE mouse model. A short-term treatment with rifaximin during the early phase of the disease, reduced seizure duration and neuropathology, and reversed some intestinal changes, strengthening the therapeutic effects of gut-based therapies in epilepsy.PMID:38608741 | DOI:10.1016/j.bbi.2024.04.007 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Valentina Kebede Teresa Ravizza Silvia Balosso Rossella Di Sapia Luca Canali Sara Soldi Serena Galletti Christina Papazlatani Panagiotis A Karas Sotirios Vasileiadis Annalisa Sforzini Laura Pasetto Valentina Bonetto Annamaria Vezzani Loredana Vesci Source Type: research
Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis
We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to asse...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Mattia Campana Vladislav Yakimov Joanna Moussiopoulou Isabel Maurus Lisa L öhrs Florian Raabe Iris J äger Matin Mortazavi Michael E Benros Rose Jeppesen Gerd Meyer Zu H örste Michael Heming Eloi Gin é-Servén Javier Labad Ester Boix Belinda Lennox Kse Source Type: research
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii
Brain Behav Immun. 2024 Apr 10:S0889-1591(24)00353-2. doi: 10.1016/j.bbi.2024.04.008. Online ahead of print.ABSTRACTChronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive deficits. We found that T. gondii infection induced cognitive deficits in mice, which was characterized by synaptic ultrastructure impairment and neuroinflammation in the hippocampus. Moreover, the infection led to g...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Xiaoying Yang Yuying Zhou Shimin Tan Xiaokang Tian Xianran Meng Yiling Li Beibei Zhou Guihua Zhao Xing Ge Cheng He Wanpeng Cheng Yumei Zhang Kuiyang Zheng Kun Yin Yinghua Yu Wei Pan Source Type: research
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Brain Behav Immun. 2024 Apr 10;119:286-300. doi: 10.1016/j.bbi.2024.04.009. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive neurological disorder causing memory loss and cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration remain unclear, leading to a lack of effective strategies to prevent dementia. Recent evidence highlights the role of neuroinflammation, particularly involving microglia, in Alzheimer's disease onset and progression. Characterizing the initial phase of Alzheimer's disease can lead to the discovery of new biomarkers and therapeutic targets, facilitat...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Giusy Pizzirusso Efthalia Preka Julen Goikolea Celia Aguilar-Ruiz Patricia Rodriguez-Rodriguez Guillermo Vazquez-Cabrera Simona Laterza Maria Latorre-Leal Francesca Eroli Klas Blomgren Silvia Maioli Per Nilsson Adamantia Fragkopoulou Andr é Fisahn Luis E Source Type: research
Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring
Brain Behav Immun. 2024 Apr 10;119:301-316. doi: 10.1016/j.bbi.2024.04.010. Online ahead of print.ABSTRACTMaternal obesity is associated with an increased risk of psychiatric disorders such as anxiety, depression, schizophrenia and autism spectrum disorder in the offspring. While numerous studies focus on preventive measures targeting the mothers, only a limited number provide practical approaches for addressing the damages once they are already established. We have recently demonstrated the interplay between maternal obesity and treatment with cannabidiol (CBD) on hypothalamic inflammation and metabolic disturbances, howe...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Fernanda da Silva Rodrigues Jeferson Jantsch Gabriel de Farias Fraga Vit ória Luiza de Camargo Milczarski Victor Silva Dias Camila Scheid Josias de Oliveira Merib Marcia Giovernardi Renata Padilha Guedes Source Type: research
Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy
In conclusion, gut-related alterations reflecting a dysfunctional state, occur during epilepsy development in a TLE mouse model. A short-term treatment with rifaximin during the early phase of the disease, reduced seizure duration and neuropathology, and reversed some intestinal changes, strengthening the therapeutic effects of gut-based therapies in epilepsy.PMID:38608741 | DOI:10.1016/j.bbi.2024.04.007 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Valentina Kebede Teresa Ravizza Silvia Balosso Rossella Di Sapia Luca Canali Sara Soldi Serena Galletti Christina Papazlatani Panagiotis A Karas Sotirios Vasileiadis Annalisa Sforzini Laura Pasetto Valentina Bonetto Annamaria Vezzani Loredana Vesci Source Type: research
Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis
We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to asse...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Mattia Campana Vladislav Yakimov Joanna Moussiopoulou Isabel Maurus Lisa L öhrs Florian Raabe Iris J äger Matin Mortazavi Michael E Benros Rose Jeppesen Gerd Meyer Zu H örste Michael Heming Eloi Gin é-Servén Javier Labad Ester Boix Belinda Lennox Kse Source Type: research
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii
Brain Behav Immun. 2024 Apr 10:S0889-1591(24)00353-2. doi: 10.1016/j.bbi.2024.04.008. Online ahead of print.ABSTRACTChronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive deficits. We found that T. gondii infection induced cognitive deficits in mice, which was characterized by synaptic ultrastructure impairment and neuroinflammation in the hippocampus. Moreover, the infection led to g...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Xiaoying Yang Yuying Zhou Shimin Tan Xiaokang Tian Xianran Meng Yiling Li Beibei Zhou Guihua Zhao Xing Ge Cheng He Wanpeng Cheng Yumei Zhang Kuiyang Zheng Kun Yin Yinghua Yu Wei Pan Source Type: research
